| Low NDRG2, regulated by the MYC/MIZ-1 complex and methylation, predicts poor outcomes in DLBCL patients. | Low NDRG2, regulated by the MYC/MIZ-1 complex and methylation, predicts poor outcomes in DLBCL patients.
Wu S, Zhang J, Chen S, Zhou X, Liu Y, Hua H, Qi X, Mao Y, Young KH, Lu T. | 08/30/2024 |
| A TNFalpha/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis. | A TNFα/Miz1-positive feedback loop inhibits mitophagy in hepatocytes and propagates non-alcoholic steatohepatitis.
Jin K, Shi Y, Zhang H, Zhangyuan G, Wang F, Li S, Chen C, Zhang J, Wang H, Zhang W, Sun B. | 07/19/2023 |
| Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10. | Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.
Yang J, Hou C, Wang H, Perez EA, Do-Umehara HC, Dong H, Arunagiri V, Tong F, Van Scoyk M, Cho M, Liu X, Ge X, Winn RA, Ridge KM, Wang X, Chandel NS, Liu J., Free PMC Article | 01/28/2023 |
| MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma. | MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma.
Krenz B, Gebhardt-Wolf A, Ade CP, Gaballa A, Roehrig F, Vendelova E, Baluapuri A, Eilers U, Gallant P, D'Artista L, Wiegering A, Gasteiger G, Rosenfeldt MT, Bauer S, Zender L, Wolf E, Eilers M., Free PMC Article | 01/8/2022 |
| Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1. | Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.
Yang J, Perez EA, Hou C, Zhang P, Van Scoyk M, Winn RA, Rong L, Liu J., Free PMC Article | 08/7/2021 |
| MXD/MIZ1 transcription regulatory complexes activate the expression of MYC-repressed genes. | MXD/MIZ1 transcription regulatory complexes activate the expression of MYC-repressed genes.
Shostak A, Schermann G, Diernfellner A, Brunner M. | 07/24/2021 |
| Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen. | Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen.
Liu J, Zuo Z, Zou M, Finkel T, Liu S., Free PMC Article | 01/2/2021 |
| Because RPL23 is encoded by a target gene of c-Myc, the RPL23/Miz-1/c-Myc regulatory circuit provides a feedback loop that links efficient RPL23 expression with c-Myc's function to suppress Miz-1-induced Cdk inhibitors and thereby leads to apoptotic resistance in higher-risk myelodysplastic syndrome patients | Ribosomal protein L23 negatively regulates cellular apoptosis via the RPL23/Miz-1/c-Myc circuit in higher-risk myelodysplastic syndrome.
Qi Y, Li X, Chang C, Xu F, He Q, Zhao Y, Wu L., Free PMC Article | 12/22/2018 |
| This study firstly associates ZBTB17 loss-of-function mutation with enhanced susceptibility to DCM in humans, which provides novel insight into the molecular mechanism underpinning DCM, implying potential implications for genetic counseling and personalized management of DCM | ZBTB17 loss-of-function mutation contributes to familial dilated cardiomyopathy.
Sun YM, Wang J, Xu YJ, Wang XH, Yuan F, Liu H, Li RG, Zhang M, Li YJ, Shi HY, Zhao L, Qiu XB, Qu XK, Yang YQ. | 09/1/2018 |
| These data suggest that MYC acts as a master coordinator that inversely modulates the impact of cell cycle and circadian clock on gene expression via its interaction with MIZ1. | MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation.
Shostak A, Ruppert B, Ha N, Bruns P, Toprak UH, ICGC MMML-Seq Project, Eils R, Schlesner M, Diernfellner A, Brunner M., Free PMC Article | 08/25/2018 |
| strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1/BCL6 and of Miz1/NAC1 are reported | Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1.
Stead MA, Wright SC., Free PMC Article | 07/9/2018 |
| Miz1 is a newly identified ING4-induced target gene which can drive prostate luminal epithelial cell differentiation. | Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation.
Berger PL, Winn ME, Miranti CK., Free PMC Article | 08/12/2017 |
| The mechanism of inhibition of c-Myc transcriptional activity by Miz-1 that binds c-Myc while competing for binding with Max has been described. | Miz-1 and Max compete to engage c-Myc: implication for the mechanism of inhibition of c-Myc transcriptional activity by Miz-1.
Bédard M, Maltais L, Montagne M, Lavigne P. | 06/24/2017 |
| This study used NMR to deduce the role of Miz-1 Zinc Fingers 1-4 in detecting the Miz-1 consensus sequence and preventing nonspecific DNA binding. | Structural Insights into c-Myc-interacting Zinc Finger Protein-1 (Miz-1) Delineate Domains Required for DNA Scanning and Sequence-specific Binding.
Bédard M, Roy V, Montagne M, Lavigne P., Free PMC Article | 06/24/2017 |
| the silencing of Miz-1 expression inhibited cell proliferation and promoted apoptosis in vitro and reduced the migration ability in esophageal carcinoma cells. | Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1.
Luo J, Zhang C, Wang C, Li L, Li C, Li Q, Zhang M, Wu Q. | 03/18/2017 |
| This study presents the structure of the synthetic Miz-1 Zinc Finger 13 determined by 2D (1)H-(1)H NMR. | Solution structure of the 13th C2H2 Zinc Finger of Miz-1.
Tremblay C, Bédard M, Bonin MA, Lavigne P. | 09/10/2016 |
| results indicate that Miz-1 may be directed in vivo to the novel motif sequences we have identified, where it can recruit its specific binding partners to control gene expression and ultimately regulate cell fate | Miz-1 activates gene expression via a novel consensus DNA binding motif.
Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal DJ, Knoepfler PS., Free PMC Article | 12/5/2015 |
| MIZ-1 can promote the proliferation of breast cancer cells through Wnt signaling. | Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation.
Huang Y, Wang P, Chen H, Ding Y, Chen YG. | 05/2/2015 |
| We demonstrate that Arnt is an interaction partner for Miz-1, and that Arnt has a functional role in the regulation of CDKN2B | Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways.
Aesoy R, Gradin K, Aasrud KS, Hoivik EA, Ruas JL, Poellinger L, Bakke M., Free PMC Article | 09/13/2014 |
| The functional interaction of both proteins becomes apparent at oncogenic expression levels of MYC and association with MIZ-1 mediates both oncogenic functions of MYC as well as tumor-suppressive responses to oncogenic levels of MYC. | The role of MIZ-1 in MYC-dependent tumorigenesis.
Wiese KE, Walz S, von Eyss B, Wolf E, Athineos D, Sansom O, Eilers M., Free PMC Article | 07/26/2014 |
| The ZBTB17 polymorphism rs10927875 appears to play a role in the susceptibility of the Han Chinese population to dilated cardiomyopathy . | Polymorphism of ZBTB17 gene is associated with idiopathic dilated cardiomyopathy: a case control study in a Han Chinese population.
Li X, Luo R, Mo X, Jiang R, Kong H, Hua W, Wu X., Free PMC Article | 09/28/2013 |
| The repression of TNF-alpha-induced JNK activation by Miz1 is de-repressed by its own site-specific ubiquitination and degradation. | Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation.
Liu J, Yan J, Jiang S, Wen J, Chen L, Zhao Y, Lin A., Free PMC Article | 03/10/2012 |
| study demonstrate that HPV-16 E7 forms a complex with Miz-1; These findings suggest that HPV-16 E7 protein can repress Miz-1-induced p21(Cip1) gene expression | The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1.
Morandell D, Kaiser A, Herold S, Rostek U, Lechner S, Mitterberger MC, Jansen-Dürr P, Eilers M, Zwerschke W., Free PMC Article | 03/3/2012 |
| NLRR3 is a direct target of MYCN, which associates with Miz-1 and negatively regulates NLRR3 expression. | Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its downregulation is associated with unfavorable outcome in neuroblastoma.
Akter J, Takatori A, Hossain MS, Ozaki T, Nakazawa A, Ohira M, Suenaga Y, Nakagawara A. | 01/21/2012 |
| Miz1 and Myc affect the activity of the Atr checkpoint through their effect on TopBP1 chromatin association and stability. | Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1.
Herold S, Hock A, Herkert B, Berns K, Mullenders J, Beijersbergen R, Bernards R, Eilers M., Free PMC Article | 08/30/2011 |