| LRG1 loss effectively restrains glomerular TGF-beta signaling to attenuate diabetic kidney disease. | LRG1 loss effectively restrains glomerular TGF-β signaling to attenuate diabetic kidney disease.
Wang X, Sun Z, Fu J, Fang Z, Zhang W, He JC, Lee K., | 10/25/2024 |
| LRG1 promotes atherosclerosis by inducing macrophage M1-like polarization. | LRG1 promotes atherosclerosis by inducing macrophage M1-like polarization.
Wang J, Wang J, Zhong J, Liu H, Li W, Chen M, Xu L, Zhang W, Zhang Z, Wei Z, Guo J, Wang X, Sui J, Liu X, Zhang S, Wang X., | 10/4/2024 |
| Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFbeta1- Smad1/5 signaling pathway. | Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Chen J, Zhang Z, Feng L, Liu W, Wang X, Chen H, Zou H. | 02/29/2024 |
| Exosome enriched leucine-rich alpha-2-glycoprotein-1 and extracellular matrix protein 1 proteins induce abnormal placental angiogenesis in pregnant mice. | Exosome enriched leucine-rich alpha-2-glycoprotein-1 and extracellular matrix protein 1 proteins induce abnormal placental angiogenesis in pregnant mice.
Yao J, Chang X, He Q, Li H, Duan T, Wang K. | 12/18/2023 |
| Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia-reperfusion injury by modulating various cells. | Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells.
Ruan Z, Cao G, Qian Y, Fu L, Hu J, Xu T, Wu Y, Lv Y., Free PMC Article | 12/6/2023 |
| Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation. | Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation.
Yang J, Yin GN, Kim DK, Han AR, Lee DS, Min KW, Fu Y, Yun J, Suh JK, Ryu JK, Kim HM., Free PMC Article | 06/7/2023 |
| LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation. | LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation.
Choi CHJ, Barr W, Zaman S, Model C, Park A, Koenen M, Lin Z, Szwed SK, Marchildon F, Crane A, Carroll TS, Molina H, Cohen P., Free PMC Article | 12/3/2022 |
| LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. | LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency.
O'Connor MN, Kallenberg DM, Camilli C, Pilotti C, Dritsoula A, Jackstadt R, Bowers CE, Watson HA, Alatsatianos M, Ohme J, Dowsett L, George J, Blackburn JWD, Wang X, Singhal M, Augustin HG, Ager A, Sansom OJ, Moss SE, Greenwood J., Free PMC Article | 05/28/2022 |
| Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFbeta1)/SMAD signaling pathway. | Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFβ1)/SMAD signaling pathway.
Miao Y, Wang M, Cai X, Zhu Q, Mao L., Free PMC Article | 04/16/2022 |
| LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance. | LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance.
He S, Ryu J, Liu J, Luo H, Lv Y, Langlais PR, Wen J, Dong F, Sun Z, Xia W, Lynch JL, Duggirala R, Nicholson BJ, Zang M, Shi Y, Zhang F, Liu F, Bai J, Dong LQ., Free PMC Article | 01/8/2022 |
| LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas. | LRG1 facilitates corneal fibrotic response by inducing neutrophil chemotaxis via Stat3 signaling in alkali-burned mouse corneas.
Yu B, Yang L, Song S, Li W, Wang H, Cheng J. | 09/25/2021 |
| The Skin-Liver Axis Modulates the Psoriasiform Phenotype and Involves Leucine-Rich alpha-2 Glycoprotein. | The Skin-Liver Axis Modulates the Psoriasiform Phenotype and Involves Leucine-Rich α-2 Glycoprotein.
Nakajima H, Nakajima K, Takaishi M, Ohko K, Serada S, Fujimoto M, Naka T, Sano S. | 08/28/2021 |
| A Multifunctional Role of Leucine-Rich alpha-2-Glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions. | A Multifunctional Role of Leucine-Rich α-2-Glycoprotein 1 in Cutaneous Wound Healing Under Normal and Diabetic Conditions.
Liu C, Teo MHY, Pek SLT, Wu X, Leong ML, Tay HM, Hou HW, Ruedl C, Moss SE, Greenwood J, Tavintharan S, Hong W, Wang X., Free PMC Article | 02/2/2021 |
| Evaluation of leucine-rich alpha-2 glycoprotein as a biomarker of fetal infection. | Evaluation of leucine-rich alpha-2 glycoprotein as a biomarker of fetal infection.
Kajimoto E, Endo M, Fujimoto M, Matsuzaki S, Fujii M, Yagi K, Kakigano A, Mimura K, Tomimatsu T, Serada S, Takeuchi M, Yoshino K, Ueda Y, Kimura T, Naka T., Free PMC Article | 01/9/2021 |
| LRG1 Promotes Keratinocyte Migration and Wound Repair through Regulation of HIF-1alpha Stability. | LRG1 Promotes Keratinocyte Migration and Wound Repair through Regulation of HIF-1α Stability.
Gao Y, Xie Z, Ho C, Wang J, Li Q, Zhang Y, Zhou J. | 09/19/2020 |
| A highly complex molecular network involving LRG1, TGFbeta1, PPARbeta/delta, and SMRT is involved in regulating cardiac fibroblast activation and cardiac fibrosis. | Collaborative Regulation of LRG1 by TGF-β1 and PPAR-β/δ Modulates Chronic Pressure Overload-Induced Cardiac Fibrosis.
Liu C, Lim ST, Teo MHY, Tan MSY, Kulkarni MD, Qiu B, Li A, Lal S, Dos Remedios CG, Tan NS, Wahli W, Ferenczi MA, Song W, Hong W, Wang X. | 06/20/2020 |
| Study revealed the association between mechanical force and pathological angiogenesis through our newly defined mechanical related secretory protein LRG-1. Study identified the crucial role of LRG-1 in the progression of skin fibrosis. Inhibition of FAK or ERK attenuates LRG-1 expression through the ELK1 transcription factor, which binds to the LRG-1 promoter region after transcription initiation by mechanical force. | Mechanical strain promotes skin fibrosis through LRG-1 induction mediated by ELK1 and ERK signalling.
Gao Y, Zhou J, Xie Z, Wang J, Ho CK, Zhang Y, Li Q., Free PMC Article | 05/9/2020 |
| Overexpression of LRG1 protein using an AAV-mediated method promoted neuronal injury after transient middle cerebral artery occlusion with enhanced apoptosis and autophagy. This function might occur through the activation of the TGFbeta-smad1/5 signaling pathway by the up-regulation of ALK1 expression. | LRG1 Promotes Apoptosis and Autophagy through the TGFβ-smad1/5 Signaling Pathway to Exacerbate Ischemia/Reperfusion Injury.
Jin J, Sun H, Liu D, Wang H, Liu Q, Chen H, Zhong D, Li G. | 03/14/2020 |
| These findings identify LRG1 as a potential novel pathogenic mediator of diabetic glomerular neoangiogenesis and a risk factor in DKD progression. | LRG1 Promotes Diabetic Kidney Disease Progression by Enhancing TGF-β-Induced Angiogenesis.
Hong Q, Zhang L, Fu J, Verghese DA, Chauhan K, Nadkarni GN, Li Z, Ju W, Kretzler M, Cai GY, Chen XM, D'Agati VD, Coca SG, Schlondorff D, He JC, Lee K., Free PMC Article | 12/21/2019 |
| At this late stage, glomerular VEGF and fibrosis-related-gene expression was also significantly increased compared with nondiabetic db/m mice. These results suggest that LRG1 plays a pivotal role in the initial development of diabetic nephropathy by promoting abnormal angiogenesis, thereby suggesting that LRG1 is a potential preemptive therapeutic target of diabetic nephropathy. | Early Enhanced Leucine-Rich α-2-Glycoprotein-1 Expression in Glomerular Endothelial Cells of Type 2 Diabetic Nephropathy Model Mice.
Haku S, Wakui H, Azushima K, Haruhara K, Kinguchi S, Ohki K, Uneda K, Kobayashi R, Matsuda M, Yamaji T, Yamada T, Minegishi S, Ishigami T, Yamashita A, Ohashi K, Tamura K., Free PMC Article | 03/23/2019 |
| our data suggest that LRG promotes lung fibrosis by modulating TGF-beta-induced Smad2 phosphorylation and activating profibrotic responses in fibroblasts. | Leucine-rich α-2 glycoprotein promotes lung fibrosis by modulating TGF-β signaling in fibroblasts.
Honda H, Fujimoto M, Serada S, Urushima H, Mishima T, Lee H, Ohkawara T, Kohno N, Hattori N, Yokoyama A, Naka T., Free PMC Article | 08/4/2018 |
| Our study indicates that LRG promotes the differentiation and the proliferation of Th17 in vivo and contributes to the development of collagen-induced arthritis | Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells.
Urushima H, Fujimoto M, Mishima T, Ohkawara T, Honda H, Lee H, Kawahata H, Serada S, Naka T., Free PMC Article | 04/14/2018 |
| in vitro stimulation of mouse renal cortical tubular epithelial cells with excessive ALB led to LRG mRNA up-regulation and its protein secretion, which was effectively blocked by IL-1 receptor antagonist. These results suggest that urinary LRG could be applied to a biomarker detecting renal tubular injury in various renal diseases. | Leucine rich α-2 glycoprotein is a potential urinary biomarker for renal tubular injury.
Lee H, Fujimoto M, Ohkawara T, Honda H, Serada S, Terada Y, Naka T. | 04/14/2018 |
| Hippocampal LRG overexpression contributes to synaptic dysfunction, which leads to memory impairment with advance of age. | Leucine-rich α2-glycoprotein overexpression in the brain contributes to memory impairment.
Akiba C, Nakajima M, Miyajima M, Ogino I, Miura M, Inoue R, Nakamura E, Kanai F, Tada N, Kunichika M, Yoshida M, Nishimura K, Kondo A, Sugano H, Arai H. | 01/6/2018 |
| This study shows that TNF-alpha is the predominant proinflammatory cytokine that induces the secretion of LRG1. LRG1 contributes to angiogenesis-coupled de novo bone formation by increasing angiogenesis and recruiting MSCs in the subchondral bone of osteoarthritis joints. | TNF-α-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis.
Wang Y, Xu J, Zhang X, Wang C, Huang Y, Dai K, Zhang X., Free PMC Article | 11/25/2017 |