| SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis. | SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis.
Li X, Tao S, Xu Z, Ren Y, Xiang W, He X. | 03/13/2024 |
| Smurf1 Modulates Smad Signaling Pathway in Fibrotic Cataract Formation. | Smurf1 Modulates Smad Signaling Pathway in Fibrotic Cataract Formation.
Jiang F, Yang Y, Ni Y, Qin Y, Yuan F, Ju R, Wu M., Free PMC Article | 03/12/2024 |
| piR-368 promotes odontoblastic differentiation of dental papilla cells via the Smad1/5 signaling pathway by targeting Smurf1. | piR-368 promotes odontoblastic differentiation of dental papilla cells via the Smad1/5 signaling pathway by targeting Smurf1.
Xing X, She Y, Yuan G, Yang G. | 02/9/2024 |
| Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate beta-cell proliferation and mass in mice. | Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice.
Hou X, Chen Y, Zhou B, Tang W, Ding Z, Chen L, Wu Y, Yang H, Du C, Yang D, Ma G, Cao H., Free PMC Article | 11/1/2023 |
| A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity. | A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity.
Zhao M, Zhang Y, Qiang L, Lu Z, Zhao Z, Fu Y, Wu B, Chai Q, Ge P, Lei Z, Zhang X, Li B, Wang J, Zhang L, Liu CH. | 10/13/2023 |
| The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy. | The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy.
Lin Z, Li S, Xiao H, Xu Z, Li C, Zeng J, Wang S, Liu Z, Huang H. | 09/6/2023 |
| Smurf1 regulates ameloblast polarization by ubiquitination-mediated degradation of RhoA. | Smurf1 regulates ameloblast polarization by ubiquitination-mediated degradation of RhoA.
Niu H, Bi F, Zhao W, Xu Y, Han Q, Guo W, Chen Y., Free PMC Article | 04/6/2023 |
| HSP90beta chaperoning SMURF1-mediated LATS proteasomal degradation in the regulation of bone formation. | HSP90β chaperoning SMURF1-mediated LATS proteasomal degradation in the regulation of bone formation.
Qu M, Gong Y, Jin Y, Gao R, He Q, Xu Y, Shen T, Mei L, Xu C, Hussain M, Barkat MQ, Wu X. | 01/7/2023 |
| Deletion of Smurf1 attenuates liver steatosis via stabilization of p53. | Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.
Lin W, Zhang X, Zhang C, Li L, Zhang J, Xie P, Zhan Y, An W. | 10/15/2022 |
| MicroRNA 379 Regulates Klotho Deficiency-Induced Cardiomyocyte Apoptosis Via Repression of Smurf1. | MicroRNA 379 Regulates Klotho Deficiency-Induced Cardiomyocyte Apoptosis Via Repression of Smurf1.
Chen K, Zhang B, Sun Z., Free PMC Article | 01/15/2022 |
| Overexpression of miR-195-5p reduces osteoporosis through activating BMP-2/SMAD/Akt/RUNX2 pathway via targeting SMURF1. | Overexpression of miR-195-5p reduces osteoporosis through activating BMP-2/SMAD/Akt/RUNX2 pathway via targeting SMURF1.
Ye LC, Qian LF, Liang L, Jiang LJ, Che ZY, Guo YH. | 09/25/2021 |
| Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner. | Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner.
Zhang X, Zhan Y, Lin W, Zhao F, Guo C, Chen Y, Du M, Li D, Zhang L, An W, Wang HR, Xie P. | 01/23/2021 |
| SMURF1 is a critical regulator of outflow tract septation and cell-type specification during heart development | The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development.
Koefoed K, Skat-Rørdam J, Andersen P, Warzecha CB, Pye M, Andersen TA, Ajbro KD, Bendsen E, Narimatsu M, Vilhardt F, Pedersen LB, Wrana JL, Anderson RH, Møllgård K, Christensen ST, Larsen LA., Free PMC Article | 10/19/2019 |
| that Smurf1 promotes Lhx9 ubiquitylation and is involved in testosterone production in Leydig cells directly | Smad ubiquitylation regulatory factor 1 promotes LIM-homeobox gene 9 degradation and represses testosterone production in Leydig cells.
Hu F, Zhu Q, Sun B, Cui C, Li C, Zhang L. | 03/23/2019 |
| Smurf1 is a new positive regulator for macrophage proliferation and apoptosis, but a negative regulator for macrophage migration. | Smurf1 regulates macrophage proliferation, apoptosis and migration via JNK and p38 MAPK signaling pathways.
Guo J, Qiu X, Zhang L, Wei R. | 01/12/2019 |
| Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis | Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis.
Liang C, Peng S, Li J, Lu J, Guan D, Jiang F, Lu C, Li F, He X, Zhu H, Au DWT, Yang D, Zhang BT, Lu A, Zhang G., Free PMC Article | 12/22/2018 |
| Smurf1 expression in osteoblast differentiation is regulated by CRTC2. | CRTC2 suppresses BMP2-induced osteoblastic differentiation via Smurf1 expression in MC3T3-E1 cells.
Kim KM, Jeon WJ, Kim EJ, Jang WG. | 12/22/2018 |
| Smurf1 interacts with and targets Securin, an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation. | Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition.
Wei R, Li B, Guo J, Li M, Zhu R, Yang X, Gao R. | 05/19/2018 |
| Six2 mediates the protective effects of GDNF on damaged DA neurons by regulating Smurf1 expression. | Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression.
Gao J, Kang XY, Sun S, Li L, Zhang BL, Li YQ, Gao DS., Free PMC Article | 11/4/2017 |
| TGF-beta inhibited osteoblastic differentiation by inducing the MAPK-ERK pathway which upregulated the expression of ubiquitin ligase SMURF1 and resulted in reduced presence of osteogenic proteins. | TGF-β inhibits osteogenesis by upregulating the expression of ubiquitin ligase SMURF1 via MAPK-ERK signaling.
Sun X, Xie Z, Ma Y, Pan X, Wang J, Chen Z, Shi P. | 10/28/2017 |
| demonstration that Smurf1 acts as a brake for integrin activation by controlling Kindlin-2 protein levels, a new mechanism that permits precise modulation of integrin-mediated cellular functions | Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation.
Wei X, Wang X, Zhan J, Chen Y, Fang W, Zhang L, Zhang H., Free PMC Article | 10/7/2017 |
| miR-140-5p and SMURF1 are key regulators of disease pathology in pulmonary arterial hypertension | MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.
Rothman AM, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen RM, Guth-Gundel S, Southwood M, Morrell NW, Thomas M, Francis SE, Rowlands DJ, Lawrie A., Free PMC Article | 09/30/2017 |
| Smurf1 is required for selective autophagy of Mycobacterium tuberculosis and host defense against tuberculosis infection. | The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
Franco LH, Nair VR, Scharn CR, Xavier RJ, Torrealba JR, Shiloh MU, Levine B., Free PMC Article | 09/16/2017 |
| Smurf1 regulates glucose metabolism and inhibits osteoblast differentiation. Smurf1 function requires the presence of serine 148 (S148) in Smurf1. | Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148.
Shimazu J, Wei J, Karsenty G., Free PMC Article | 12/24/2016 |
| Smurf1 mediates NGF signaling and ubiquitinates RhoA in growth cones, regulating the need for local translation and degradation. | Coupled local translation and degradation regulate growth cone collapse.
Deglincerti A, Liu Y, Colak D, Hengst U, Xu G, Jaffrey SR., Free PMC Article | 04/2/2016 |