| miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis. | miR-375-3p targets YWHAB to attenuate intestine injury in neonatal necrotizing enterocolitis.
Nan L, Kaisi F, Mengzhen Z, Yang Y, Jiaming Y, Huirong Y, Xinwei H, Chen W, Liucheng Y, Kai W. | 03/11/2024 |
| 14-3-3beta isoform is specifically acetylated at Lys51 during differentiation to the osteogenic lineage. | 14-3-3β isoform is specifically acetylated at Lys51 during differentiation to the osteogenic lineage.
Frontini-López YR, Gojanovich AD, Del Veliz S, Uhart M, Bustos DM. | 03/19/2022 |
| Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer. | Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer.
Zhang X, Zhang Q, Zhang K, Wang F, Qiao X, Cui J., Free PMC Article | 12/25/2021 |
| Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3. | Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3.
Kang H, Jeon YH, Ham M, Ko K, Kim IY., Free PMC Article | 11/6/2021 |
| The regulatory protein 14-3-3beta binds to the IQ motifs of myosin-IC independent of phosphorylation. | The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independent of phosphorylation.
Ji HH, Ostap EM., Free PMC Article | 12/12/2020 |
| YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization and its activity. | YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.
Xu Y, Ren J, He X, Chen H, Wei T, Feng W., Free PMC Article | 06/20/2020 |
| YWHAB was identified and validated in association with pulmonary arterial hypertension progression, which might serve as a biomarker and/or therapeutic target for pulmonary arterial hypertension. | Integrated bioinformatic analysis reveals YWHAB as a novel diagnostic biomarker for idiopathic pulmonary arterial hypertension.
Wang T, Zheng X, Li R, Liu X, Wu J, Zhong X, Zhang W, Liu Y, He X, Liu W, Wang H, Zeng H. | 04/4/2020 |
| the interaction of lncRNA RP11-732M18.3 with 14-3-3beta/alpha increases the degradation of the p21 protein. lncRNA RP11-732M18.3 promoted the recruitment of ubiquitin-conjugating enzyme E2 E1 to 14-3-3beta/alpha and the binding of 14-3-3beta/alpha with ubiquitin-conjugating enzyme E2 E1 (UBE2E1) promoted the degradation of p21. | The binding of lncRNA RP11-732M18.3 with 14-3-3 β/α accelerates p21 degradation and promotes glioma growth.
Kang CM, Bai HL, Li XH, Huang RY, Zhao JJ, Dai XY, Zheng L, Qiu YR, Hu YW, Wang Q., Free PMC Article | 01/11/2020 |
| 14-3-3 beta and gamma function as positive regulators of GR transactivation and glucocorticoid-mediated hepatic gluconeogenesis. | Roles of 14-3-3β and γ in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis.
Hwang Y, An HT, Kang M, Ko J. | 05/18/2019 |
| findings advance our understanding of how phosphorylation of lipin 1beta phosphatidate phosphatase regulates its interaction with 14-3-3beta protein and intracellular localization and uncover a mechanism by which CKII regulates cellular physiology. | Casein kinase II-mediated phosphorylation of lipin 1β phosphatidate phosphatase at Ser-285 and Ser-287 regulates its interaction with 14-3-3β protein.
Hennessy M, Granade ME, Hassaninasab A, Wang D, Kwiatek JM, Han GS, Harris TE, Carman GM., Free PMC Article | 05/4/2019 |
| Our results indicate that 14-3-3beta negatively regulates senescence in glioblastoma cells via the ERK/SKP2/p27 pathway. | 14-3-3β Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway.
Seo SB, Lee JJ, Yun HH, Im CN, Kim YS, Ko JH, Lee JH. | 01/12/2019 |
| 14-3-3beta protein activates Pseudomonas exotoxin-S and exotoxin-T ADP-ribosyltransferase domains by chaperoning their hydrophobic surfaces independently of the amphipathic C-terminal segment. | 14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Karlberg T, Hornyak P, Pinto AF, Milanova S, Ebrahimi M, Lindberg M, Püllen N, Nordström A, Löverli E, Caraballo R, Wong EV, Näreoja K, Thorsell AG, Elofsson M, De La Cruz EM, Björkegren C, Schüler H., Free PMC Article | 12/22/2018 |
| Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 and MMP9 through PI3 kinase/Akt protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC) cells. | 14-3-3β Promotes Migration and Invasion of Human Hepatocellular Carcinoma Cells by Modulating Expression of MMP2 and MMP9 through PI3K/Akt/NF-κB Pathway.
Tang Y, Lv P, Sun Z, Han L, Zhou W., Free PMC Article | 08/13/2016 |
| These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease. | 14-3-3β and γ differentially regulate peroxisome proliferator activated receptor γ2 transactivation and hepatic lipid metabolism.
Park S, Yoo S, Kim J, An HT, Kang M, Ko J. | 12/19/2015 |
| miR-152 controls both the expression of 14-3-3beta and HLA-G and exerts a dual role in tumor cells by both altering the immunogenicity and the tumorigenicity | Identification of 14-3-3β gene as a novel miR-152 target using a proteome-based approach.
Jasinski-Bergner S, Stehle F, Gonschorek E, Kalich J, Schulz K, Huettelmaier S, Braun J, Seliger B., Free PMC Article | 01/24/2015 |
| Data suggest that serum 14-3-3beta concentrations may constitute a useful marker for blood brain barrier damage severity and follow up in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. | 14-3-3β protein expression in eosinophilic meningitis caused by Angiostrongylus cantonensis infection.
Tsai HC, Huang YL, Chen YS, Yen CM, Tsai R, Lee SS, Tai MH., Free PMC Article | 11/8/2014 |
| Using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT, APAF1, BCL2, BAD, BID, MCL1, BIRC4, BCL2L1, ENDOG, YWHAB, and YWHAQ, influence promoter activity in an allele-specific manner. | Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemia.
Sanchez R, St-Cyr J, Lalonde ME, Healy J, Richer C, Gagné V, Laverdière C, Silverman LB, Sallan SE, Neuberg D, Kutok JL, Kritikou EA, Krajinovic M, Sinnett D., Free PMC Article | 07/26/2014 |
| Crystal structure of Myo1c/14-3-3beta complex, which has been implicated in the exocytosis of glucose transporter 4 storage vesicles during insulin-stimulated glucose uptake. | Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding.
Münnich S, Taft MH, Manstein DJ. | 07/5/2014 |
| Data identified three classes of 14-3-3 targets that all have two binding sites, but displayed synergistic interaction between converging signalling pathways for different ranges of parameter values. | Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins.
Kleppe R, Ghorbani S, Martinez A, Haavik J. | 03/1/2014 |
| These results indicate that the six YWHAB polymorphisms are not associated with the genetic susceptibility to sporadic Creutzfeldt-Jakob disease. | Lack of association between 14-3-3 beta gene (YWHAB) polymorphisms and sporadic Creutzfeldt-Jakob disease (CJD).
Jeong BH, Jin HT, Choi EK, Carp RI, Kim YS. | 04/13/2013 |
| 14-3-3beta binding to phosphorylated CFTR augments its biogenesis by reducing retrograde retrieval of CFTR to the endoplasmic reticulum. This mechanism permits cAMP/PKA stimulation to make more CFTR available for anion secretion. | Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis.
Liang X, Da Paula AC, Bozóky Z, Zhang H, Bertrand CA, Peters KW, Forman-Kay JD, Frizzell RA., Free PMC Article | 08/4/2012 |
| Data identified 14-3-3beta as a prognostic biomarker. | The proteomics of colorectal cancer: identification of a protein signature associated with prognosis.
O'Dwyer D, Ralton LD, O'Shea A, Murray GI., Free PMC Article | 04/7/2012 |
| Modulation of matrix metalloproteinase 1 by 14-3beta/alpha, may be important in the alteration of collagenase production associated with airway remodelling in obstructive lung diseases | Extracellular 14-3-3 from human lung epithelial cells enhances MMP-1 expression.
Asdaghi N, Kilani RT, Hosseini-Tabatabaei A, Odemuyiwa SO, Hackett TL, Knight DA, Ghahary A, Moqbel R. | 03/24/2012 |
| Analyses show that high cytoplasmic levels of 14-3-3beta and epsilon independently correlate with poor disease-specific survival in vulvar squamous cell carcinoma cases. | The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3β and ε are independent prognostic factors for these tumors.
Wang Z, Nesland JM, Suo Z, Trope CG, Holm R., Free PMC Article | 03/3/2012 |
| In glioblastoma PTPIP51 expression increases with the grade of malignancy and PTPIP51 interacts in situ with 14-3-3ss and PTP1B. | PTPIP51, a positive modulator of the MAPK/Erk pathway, is upregulated in glioblastoma and interacts with 14-3-3β and PTP1B in situ.
Petri MK, Koch P, Stenzinger A, Kuchelmeister K, Nestler U, Paradowska A, Steger K, Brobeil A, Viard M, Wimmer M. | 02/4/2012 |