| Developmentally Programmed Tankyrase Activity Upregulates beta-Catenin and Licenses Progression of Embryonic Genome Activation. | Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.
Gambini A, Stein P, Savy V, Grow EJ, Papas BN, Zhang Y, Kenan AC, Padilla-Banks E, Cairns BR, Williams CJ., Free PMC Article | 01/2/2021 |
| Study using Villin-creERT2;Tnks1-/-;Tnks2fl/fl mice, which harbored conventional Tnks1 deletion and inducible intestinal epithelium-specific Tnks2 knockout, shows that tankyrases regulate adult intestinal Lgr5+ stem cells and epithelium homeostasis by preventing cell death and promoting cell proliferation. | Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death.
Ye P, Chiang YJ, Qi Z, Li Y, Wang S, Liu Y, Li X, Chen YG., Free PMC Article | 01/19/2019 |
| Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP. | Tankyrase inhibition aggravates kidney injury in the absence of CD2AP.
Kuusela S, Wang H, Wasik AA, Suleiman H, Lehtonen S., Free PMC Article | 10/28/2017 |
| a new function of RNF146 and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT proteins at the apical membrane, is reported. | The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.
Campbell CI, Samavarchi-Tehrani P, Barrios-Rodiles M, Datti A, Gingras AC, Wrana JL. | 08/5/2017 |
| These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation. | Structural insights into SAM domain-mediated tankyrase oligomerization.
DaRosa PA, Ovchinnikov S, Xu W, Klevit RE., Free PMC Article | 07/15/2017 |
| TNKS2 is required in insulin-stimulated glucose disposal. | The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation.
Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z, Lin SY, Lin SC., Free PMC Article | 12/22/2012 |
| Study shows that TNKS2, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation in osteoclasts; cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein destruction. | Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism.
Levaot N, Voytyuk O, Dimitriou I, Sircoulomb F, Chandrakumar A, Deckert M, Krzyzanowski PM, Scotter A, Gu S, Janmohamed S, Cong F, Simoncic PD, Ueki Y, La Rose J, Rottapel R., Free PMC Article | 02/4/2012 |
| Data show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt ligands. | Tankyrase is necessary for canonical Wnt signaling during kidney development.
Karner CM, Merkel CE, Dodge M, Ma Z, Lu J, Chen C, Lum L, Carroll TJ., Free PMC Article | 09/27/2010 |
| tankyrase 2is essential but redundant for mouse embryonic development | Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.
Chiang YJ, Hsiao SJ, Yver D, Cushman SW, Tessarollo L, Smith S, Hodes RJ., Free PMC Article | 01/21/2010 |
| Tnks2 has a role in normal growth and development but is not essential for telomere length maintenance or telomere capping in mice. | Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping.
Hsiao SJ, Poitras MF, Cook BD, Liu Y, Smith S., Free PMC Article | 01/21/2010 |
| inactivation of tankyrase 2 does not result in the alteration in telomere length when monitored through multiple generations of breeding, tankyrase 2 functions in potentially telomerase-independent pathways to affect overall development and/or metabolism. | Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice.
Chiang YJ, Nguyen ML, Gurunathan S, Kaminker P, Tessarollo L, Campisi J, Hodes RJ., Free PMC Article | 01/21/2010 |