| The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes. | The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes.
Cao D, Ma B, Cao Z, Xu X, Zhang X, Xiang Y., Free PMC Article | 08/14/2024 |
| Identification of the miR-423-3p/VLDLR Regulatory Network for Glioma Using Transcriptome Analysis. | Identification of the miR-423-3p/VLDLR Regulatory Network for Glioma Using Transcriptome Analysis.
Song Y, Jiao H, Lin Q, Zhang X, Chen X, Wei Z, Yi L. | 12/10/2022 |
| ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium. | ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium.
Ma X, Takahashi Y, Wu W, Liang W, Chen J, Chakraborty D, Li Y, Du Y, Benyajati S, Ma JX., Free PMC Article | 11/27/2021 |
| Expression level of VLDL receptor and VLDL-c levels in the malignant and benign breast tumors: The correlation with miRNA-4465 and miRNA-1297. | Expression level of VLDL receptor and VLDL-c levels in the malignant and benign breast tumors: The correlation with miRNA-4465 and miRNA-1297.
Mosapour A, Karami Tehrani FS, Atri M. | 07/17/2021 |
| Four single nucleotide polymorphisms (SNPs); rs6921438 and rs4416670 in LOC100132354-C6orf223, rs6993770 in ZFPM2, and rs10738760 in VLDLR-KCNV2 were reported to explain up to 50% of the heritability of vascular endothelial growth factor circulating levels. These SNPs were also studied for possible associations with circulating lipid levels in supposedly healthy European individuals and in a limited number of Iranian indi | Association between SNPs of Circulating Vascular Endothelial Growth Factor Levels, Hypercholesterolemia and Metabolic Syndrome.
Salami A, El Shamieh S., Free PMC Article | 02/29/2020 |
| Postprandial VLDL particles are strongly bound and internalized into cells expressing the VLDL receptor. The presence of various specific ligands in VLDL remnants may enhance the capacity for binding to the VLDL receptor, which play the role primarily for energy delivery to the peripheral tissues, but is also a causal factor in atherogenic diseases when excessively and/or continuously remained in plasma. | The VLDL receptor plays a key role in the metabolism of postprandial remnant lipoproteins.
Nakajima K, Tokita Y, Tanaka A, Takahashi S. | 12/14/2019 |
| This study presents the nuclear magnetic resonance solution structure of the recombinant VLDLR(2-4) fragment containing all three fibrin-binding cysteine-rich (CR) domains of this receptor. | Nuclear Magnetic Resonance Solution Structure of the Recombinant Fragment Containing Three Fibrin-Binding Cysteine-Rich Domains of the Very Low Density Lipoprotein Receptor.
Banerjee K, Yakovlev S, Gruschus JM, Medved L, Tjandra N., Free PMC Article | 06/29/2019 |
| In summary, ER retention of pathogenic VLDLR mutants involves binding to calnexin, elevated endoplasmic reticulum stress, and delayed degradation which is dependent on SEL1L. | Degradation routes of trafficking-defective VLDLR mutants associated with Dysequilibrium syndrome.
Kizhakkedath P, John A, Al-Gazali L, Ali BR., Free PMC Article | 12/1/2018 |
| Our findings described an atherogenic phenotype characterized by low VLDL-C but high VLDLR mRNA expression in peripheral WBCs, which suggested that VLDLR in all types of peripheral WBCs may be involved in lipid deposition, and VLDL-C and VLDLR may co-determine the development of atherosclerosis. | Low Very low-Density Lipoprotein Cholesterol but High Very low-Density Lipoprotein Receptor mRNA Expression in Peripheral White Blood Cells: An Atherogenic Phenotype for Atherosclerosis in a Community-Based Population.
Zhao F, Qi Y, Liu J, Wang W, Xie W, Sun J, Liu J, Hao Y, Wang M, Li Y, Zhao D., Free PMC Article | 07/14/2018 |
| In the second family, we identified a previously unreported homozygous missense change, c.154T > C (p.Cys52Arg) in the VLDLR gene | Whole exome sequencing is necessary to clarify ID/DD cases with de novo copy number variants of uncertain significance: Two proof-of-concept examples.
Giorgio E, Ciolfi A, Biamino E, Caputo V, Di Gregorio E, Belligni EF, Calcia A, Gaidolfi E, Bruselles A, Mancini C, Cavalieri S, Molinatto C, Cirillo Silengo M, Ferrero GB, Tartaglia M, Brusco A. | 10/28/2017 |
| VLDLR expression was negatively regulated by miR-200c Colorectal cancer (CRC) cells and their expression levels were inversely correlated in CRC patients. | Decreased expression of VLDLR is inversely correlated with miR-200c in human colorectal cancer.
Kim BK, Yoo HI, Lee AR, Choi K, Yoon SK. | 09/9/2017 |
| We screened for mutations in RELN or VLDLR and compared the phenotype of these patients with that of previously reported patients. differences in clinical severity, involvement of the cerebellar hemispheres, together with the severity of the neocortical defect, enables RELN-mutated patients to be distinguished from VLDLR-mutated patients. | RELN and VLDLR mutations underlie two distinguishable clinico-radiological phenotypes.
Valence S, Garel C, Barth M, Toutain A, Paris C, Amsallem D, Barthez MA, Mayer M, Rodriguez D, Burglen L. | 07/8/2017 |
| Data suggest that, in the binding of fibrin beta N-domains and the (1-8) peptide fragment of VLDLR (very low density lipoprotein receptor), the second and third Lys/Arg clusters in fibrin make major contributions to this interaction while the contribution of the first cluster is moderate. | Interaction of Fibrin with the Very Low-Density Lipoprotein (VLDL) Receptor: Further Characterization and Localization of the VLDL Receptor-Binding Site in Fibrin βN-Domains.
Yakovlev S, Medved L., Free PMC Article | 06/24/2017 |
| The presence of reelin was elevated in junctional areas as in dysplastic nevi. VLDLR presented positive values in 16 cases (16/ 32) and ApoER2 was weak positive in 7 cases. | Reelin and its receptors, VLDLR and ApoER2, in melanocytic nevi.
Mihail A, Coman G, Staniceanu F, Coman L, Zurac S, Coman OA., Free PMC Article | 05/6/2017 |
| These results for the first time demonstrated that SalA protected against IS/RP-induced endothelial barrier dysfunction through suppression of VLDL receptor expression | SalA attenuates ischemia/reperfusion-induced endothelial barrier dysfunction via down-regulation of VLDL receptor expression.
Yang D, Zhang P, Wang T, Gao L, Qiao Z, Liang Y, Yu B. | 08/6/2016 |
| these results suggest that VLDLR functions in vivo as an HCV receptor independent of canonical CD81-mediated HCV entry. | Hepatitis C virus utilizes VLDLR as a novel entry pathway.
Ujino S, Nishitsuji H, Hishiki T, Sugiyama K, Takaku H, Shimotohno K., Free PMC Article | 05/14/2016 |
| the results obtained indicate that minimal fibrin-binding structures are located within the second and third CR domains of the VLDL receptor and the presence of the fourth CR domain is required for high-affinity binding | Interaction of Fibrin with the Very Low Density Lipoprotein Receptor: Further Characterization and Localization of the Fibrin-Binding Site.
Yakovlev S, Medved L., Free PMC Article | 10/17/2015 |
| The results of this study demonstrated the presence of reelin, its receptors VLDLR and ApoER2 as well as Dab1 in the ENS and might indicate a novel role of the reelin system in regulating neuronal plasticity and pre-synaptic functions in the ENS. | Expression and regulation of reelin and its receptors in the enteric nervous system.
Böttner M, Ghorbani P, Harde J, Barrenschee M, Hellwig I, Vogel I, Ebsen M, Förster E, Wedel T. | 04/18/2015 |
| these results suggested that the miR-135a-VLDLR-p38 axis may contribute to gallbladder cancer cell proliferation | MicroRNA-135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer.
Zhou H, Guo W, Zhao Y, Wang Y, Zha R, Ding J, Liang L, Yang G, Chen Z, Ma B, Yin B., Free PMC Article | 11/8/2014 |
| study identified a novel homozygous VLDLR c.2248C>T mutation (p.Q750X) and distinctive MRI findings in 2 siblings with ataxia; also marked vitamin E deficiency was detected in the proband | Mutations in VLDLR associated with ataxia with secondary vitamin E deficiency.
Kruer MC, Jepperson TN, Weimer JM, Mroch A, Davis-Keppen L, Crotwell P, Parboosingh J. | 08/9/2014 |
| these results identify a novel role for the VLDLR as a negative regulator of DC-mediated adaptive immune responses in HDM-induced allergic airway inflammation. | The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses.
Fredriksson K, Mishra A, Lam JK, Mushaben EM, Cuento RA, Meyer KS, Yao X, Keeran KJ, Nugent GZ, Qu X, Yu ZX, Yang Y, Raghavachari N, Dagur PK, McCoy JP, Levine SJ., Free PMC Article | 06/28/2014 |
| ectopic expression of HIC1 in U2OS and MDA-MB-231 cell lines decreases expression of the ApoER2 and VLDLR genes, encoding two canonical tyrosine kinase receptors for Reelin. | The Reelin receptors ApoER2 and VLDLR are direct target genes of HIC1 (Hypermethylated In Cancer 1).
Dubuissez M, Faiderbe P, Pinte S, Dehennaut V, Rood BR, Leprince D. | 05/3/2014 |
| an unusual constellation of VLDLR mutations in Cerebellar ataxia, mental retardation and dysequilibrium syndrome 1 is reported | Cerebellar ataxia, mental retardation and dysequilibrium syndrome 1 (CAMRQ1) caused by an unusual constellation of VLDLR mutation.
Schlotawa L, Hotz A, Zeschnigk C, Hartmann B, Gärtner J, Morris-Rosendahl D. | 01/18/2014 |
| Results show variation in VLDLR is implicated in disordered gambling | Genome-wide association study of a quantitative disordered gambling trait.
Lind PA, Zhu G, Montgomery GW, Madden PA, Heath AC, Martin NG, Slutske WS., Free PMC Article | 10/19/2013 |
| These results conclude that in the hypoxic hearts of mice and men, the VLDLr gene is regulated by a direct binding of Hif-1alpha to the VLDLr promoter | Hypoxia-induced regulation of the very low density lipoprotein receptor.
Sundelin JP, Lidberg U, Nik AM, Carlsson P, Borén J. | 10/19/2013 |