| Sex-dependent expression levels of VAV1 and P2X7 in PBMC of multiple sclerosis patients. | Sex-dependent expression levels of VAV1 and P2X7 in PBMC of multiple sclerosis patients.
Rump A, Ratas K, Lepasepp TK, Suurväli J, Smolander OP, Gross-Paju K, Toomsoo T, Kanellopoulos J, Rüütel Boudinot S. | 03/6/2024 |
| Vav1-dependent Rac1 activation mediates hypoxia-induced gemcitabine resistance in pancreatic ductal adenocarcinoma cells through upregulation of HIF-1alpha expression. | Vav1-dependent Rac1 activation mediates hypoxia-induced gemcitabine resistance in pancreatic ductal adenocarcinoma cells through upregulation of HIF-1α expression.
Zhu C, Hu H, Ma Y, Xiong S, Zhu D. | 10/13/2023 |
| Unraveling the Oncogenic Potential of VAV1 in Human Cancer: Lessons from Mouse Models. | Unraveling the Oncogenic Potential of VAV1 in Human Cancer: Lessons from Mouse Models.
Shalom B, Salaymeh Y, Risling M, Katzav S., Free PMC Article | 05/24/2023 |
| RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer. | RhoA G17E/Vav1 Signaling Induces Cancer Invasion via Matrix Metalloproteinase-9 in Gastric Cancer.
Nakamura S, Kitazawa M, Miyagawa Y, Koyama M, Miyazaki S, Hondo N, Muranaka F, Tokumaru S, Yamamoto Y, Ehara T, Matsumura T, Takeoka M, Soejima Y., Free PMC Article | 01/14/2023 |
| Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation. | Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation.
Grewal RK, Das J., Free PMC Article | 06/11/2022 |
| Vav1 Promotes B-Cell Lymphoma Development. | Vav1 Promotes B-Cell Lymphoma Development.
Shalom B, Farago M, Salaymeh Y, Sebban S, Pikarsky E, Katzav S., Free PMC Article | 04/23/2022 |
| Regulatory interplay between Vav1, Syk and beta-catenin occurs in lung cancer cells. | Regulatory interplay between Vav1, Syk and β-catenin occurs in lung cancer cells.
Boudria R, Laurienté V, Oudar A, Harouna-Rachidi S, Dondi E, Le Roy C, Gardano L, Varin-Blank N, Guittat L. | 04/9/2022 |
| Identification of molecular subtyping system and four-gene prognostic signature with immune-related genes for uveal melanoma. | Identification of molecular subtyping system and four-gene prognostic signature with immune-related genes for uveal melanoma.
Xia F, Yu Z, Deng A, Gao G., Free PMC Article | 03/5/2022 |
| Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA). | Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA).
Brugnoli F, Grassilli S, Cardinale V, Carpino G, Gaudio E, Alvaro D, Capitani S, Bertagnolo V., Free PMC Article | 03/5/2022 |
| Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis. | Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.
Robles-Valero J, Fernández-Nevado L, Lorenzo-Martín LF, Cuadrado M, Fernández-Pisonero I, Rodríguez-Fdez S, Astorga-Simón EN, Abad A, Caloto R, Bustelo XR., Free PMC Article | 01/8/2022 |
| Targeting the Vav1/miR29b axis as a potential approach for treating selected molecular subtypes of triplenegative breast cancer. | Targeting the Vav1/miR‑29b axis as a potential approach for treating selected molecular subtypes of triple‑negative breast cancer.
Grassilli S, Vezzali F, Cairo S, Brugnoli F, Volinia S, De Mattei M, Judde JG, Bertagnolo V. | 11/13/2021 |
| VAV1-overexpressing YT cells display improved cytotoxicity against malignant cells. | VAV1-overexpressing YT cells display improved cytotoxicity against malignant cells.
Smagina AS, Kulemzin SV, Yusubalieva GM, Kedrova AG, Sanzharov AE, Ivanov YV, Matvienko DA, Kalsin VA, Gorchakov AA, Baklaushev VP, Taranin AV. | 10/2/2021 |
| VAV1 Gene Polymorphism is Associated With Kidney Allograft Rejection. | VAV1 Gene Polymorphism is Associated With Kidney Allograft Rejection.
Wisniewska M, Banach B, Malinowski D, Domanski L, Sroczynski T, Dziedziejko V, Safranow K, Pawlik A. | 07/17/2021 |
| Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice. | Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice.
Salaymeh Y, Farago M, Sebban S, Shalom B, Pikarsky E, Katzav S., Free PMC Article | 06/5/2021 |
| Vav1 mutations: What makes them oncogenic? | Vav1 mutations: What makes them oncogenic?
Farago M, Yarnitzky T, Shalom B, Katzav S. | 04/24/2021 |
| VAV1 Gene Polymorphisms in Patients with Rheumatoid Arthritis. | VAV1 Gene Polymorphisms in Patients with Rheumatoid Arthritis.
Pawlik A, Malinowski D, Paradowska-Gorycka A, Safranow K, Dziedziejko V., Free PMC Article | 10/24/2020 |
| NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity. | NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity.
Wilton KM, Overlee BL, Billadeau DD., Free PMC Article | 09/26/2020 |
| Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output. | Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output.
Rodríguez-Fdez S, Citterio C, Lorenzo-Martín LF, Baltanás-Copado J, Llorente-González C, Corbalán-García S, Vicente-Manzanares M, Bustelo XR., Free PMC Article | 09/5/2020 |
| we elucidate a mechanism through which the DBL family members MCF2 and VAV1 act to drive drug resistance in human BRAFV600E-mutant melanoma cells | Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma.
Feddersen CR, Schillo JL, Varzavand A, Vaughn HR, Wadsworth LS, Voigt AP, Zhu EY, Jennings BM, Mullen SA, Bobera J, Riordan JD, Stipp CS, Dupuy AJ., Free PMC Article | 05/30/2020 |
| Vav1 interacts with EBNA1 via its C-terminal SH3 domain. This interaction suppresses the expression of a pro-apoptotic Bcl-2 family member, Bim, resulting in the resistance of the Burkitt's lymphoma cells to apoptotic inductions. | The interaction between Vav1 and EBNA1 promotes survival of Burkitt's lymphoma cells by down-regulating the expression of Bim.
Wang R, Wang J, Zhang N, Wan Y, Liu Y, Zhang L, Pan S, Zhang C, Zhang H, Cao Y. | 01/18/2020 |
| Nuclear PU.1/Vav1 association accompanies the transcription of miR-29b but, at variance with the APL-derived NB4 cells, in which the protein is required for the association of PU.1 with both miRNA promoters, Vav1 is part of molecular complexes to the PU.1 consensus site in Kasumi-1. | Vav1 is necessary for PU.1 mediated upmodulation of miR-29b in acute myeloid leukaemia-derived cells.
Vezzali F, Grassilli S, Lambertini E, Brugnoli F, Patergnani S, Nika E, Piva R, Pinton P, Capitani S, Bertagnolo V., Free PMC Article | 11/30/2019 |
| The analysis of mutants has unveiled the presence of different Vav1 signaling competent states that are influenced by phosphosites present in the N- and C-terminal domains of the protein. | New insights into the Vav1 activation cycle in lymphocytes.
Barreira M, Rodríguez-Fdez S, Bustelo XR., Free PMC Article | 08/3/2019 |
| Vav1, ectopically expressed in invasive breast tumors derived cells, downmodulates Akt acting at expression and/or activation levels depending on tumor subtype. | Vav1 downmodulates Akt in different breast cancer subtypes: a new promising chance to improve breast cancer outcome.
Grassilli S, Brugnoli F, Lattanzio R, Marchisio M, Perracchio L, Piantelli M, Bavelloni A, Capitani S, Bertagnolo V., Free PMC Article | 06/1/2019 |
| Phospho-VAV1 staining was demonstrated in the clinical specimens harboring G17V RHOA and VAV1 mutations at a higher frequency than those without. Our findings indicate that the G17V RHOA-VAV1 axis may provide a new therapeutic target in AITL. | Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma.
Fujisawa M, Sakata-Yanagimoto M, Nishizawa S, Komori D, Gershon P, Kiryu M, Tanzima S, Fukumoto K, Enami T, Muratani M, Yoshida K, Ogawa S, Matsue K, Nakamura N, Takeuchi K, Izutsu K, Fujimoto K, Teshima T, Miyoshi H, Gaulard P, Ohshima K, Chiba S., Free PMC Article | 02/9/2019 |
| Study identifies the residues on EZH2 that are critical for its interaction with VAV and demonstrate that EZH2 interactions with VAV proteins are crucial for the regulation of adhesion dynamics and cellular transformation. | EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms.
Venkatesan N, Wong JF, Tan KP, Chung HH, Yau YH, Cukuroglu E, Allahverdi A, Nordenskiöld L, Göke J, Geifman-Shochat S, Lin VCL, Madhusudhan MS, Su IH. | 10/13/2018 |