| Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes. | Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes.
Reichmann J, Dobie K, Lister LM, Crichton JH, Best D, MacLennan M, Read D, Raymond ES, Hung CC, Boyle S, Shirahige K, Cooke HJ, Herbert M, Adams IR., Free PMC Article | 02/20/2021 |
| Here the authors show that TEX19.1, which is induced by developmentally programmed DNA hypomethylation, can directly interact with the LINE-1 (L1) retrotransposon-encoded protein L1-ORF1p, stimulate its polyubiquitylation and degradation, and restrict L1 mobilization. | Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells.
MacLennan M, García-Cañadas M, Reichmann J, Khazina E, Wagner G, Playfoot CJ, Salvador-Palomeque C, Mann AR, Peressini P, Sanchez L, Dobie K, Read D, Hung CC, Eskeland R, Meehan RR, Weichenrieder O, García-Pérez JL, Adams IR., Free PMC Article | 05/5/2018 |
| These data suggest that Tex19.1 and Ubr2 are required for mouse spermatocytes to accumulate sufficient Spo11-dependent recombination to ensure that the homology search is consistently successful, and reveal a hitherto unknown genetic pathway promoting meiotic recombination in mammals. | Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes.
Crichton JH, Playfoot CJ, MacLennan M, Read D, Cooke HJ, Adams IR., Free PMC Article | 08/26/2017 |
| this study shows that TEX19 paralogs interact with PIWI proteins and the TEX19 VPTEL domain directly binds Piwi-interacting RNAs in adult testes | Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression.
Tarabay Y, Achour M, Teletin M, Ye T, Teissandier A, Mark M, Bourc'his D, Viville S. | 05/6/2017 |
| While Tex19.1 is not essential in ES cells, it is important for spermatogenesis and for placenta-supported development. | The mammalian-specific Tex19.1 gene plays an essential role in spermatogenesis and placenta-supported development.
Tarabay Y, Kieffer E, Teletin M, Celebi C, Van Montfoort A, Zamudio N, Achour M, El Ramy R, Gazdag E, Tropel P, Mark M, Bourc'his D, Viville S. | 03/8/2014 |
| Retrotransposon mRNAs are derepressed in Tex19.1(-/-) placentas and that protein encoded by the LINE-1 retrotransposon is upregulated in hypomethylated trophectoderm-derived cells that normally express Tex19.1. | The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice.
Reichmann J, Reddington JP, Best D, Read D, Ollinger R, Meehan RR, Adams IR., Free PMC Article | 11/16/2013 |
| Tex 19 paralogs exhibit a gonad and placenta-specific expression in the mouse | Tex 19 paralogs exhibit a gonad and placenta-specific expression in the mouse.
Celebi C, van Montfoort A, Skory V, Kieffer E, Kuntz S, Mark M, Viville S. | 12/22/2012 |
| Results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway. | The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis.
Yang F, Cheng Y, An JY, Kwon YT, Eckardt S, Leu NA, McLaughlin KJ, Wang PJ., Free PMC Article | 04/30/2011 |
| Mouse DAZL protein can bind to 3'UTR of mTex19.1 mRNAs and may repress mTex19.1 expression at the translational level.Confirmed by both electrophoretic mobility shift assay and translation assay in Zebrafish embryo detecting the luciferase activity. | DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression.
Zeng M, Lu Y, Liao X, Li D, Sun H, Liang S, Zhang S, Ma Y, Yang Z. | 02/8/2010 |
| Tex19.1 repressed transposable genetic elements and maintained genomic stability through successive generations. | Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice.
Ollinger R, Childs AJ, Burgess HM, Speed RM, Lundegaard PR, Reynolds N, Gray NK, Cooke HJ, Adams IR., Free PMC Article | 01/21/2010 |
| Tex19 is a mammalian-specific protein duplicated in mouse and rat, renamed Tex19.1 and Tex19.2, whereas only one form is found in human. | Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line.
Kuntz S, Kieffer E, Bianchetti L, Lamoureux N, Fuhrmann G, Viville S. | 01/21/2010 |