| UGT2B10 Genotype Influences Serum Cotinine Levels and Is a Primary Determinant of Higher Cotinine in African American Smokers. | UGT2B10 Genotype Influences Serum Cotinine Levels and Is a Primary Determinant of Higher Cotinine in African American Smokers.
Sipe CJ, Koopmeiners JS, Donny EC, Hatsukami DK, Murphy SE., Free PMC Article | 11/27/2021 |
| a cis-regulatory SNP for human UGT2B10 | rs294775 is a cis-regulatory SNP for human UGT2B10.
Ruan J, Yang YC, Long FQ, Sun C. | 09/21/2019 |
| The high prevalence of a UGT2B10 splice variant among African Americans results in lower 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), - N-glucuronidation but only a small decrease in total NNAL glucuronidation. Therefore, despite the significant contribution of UGT2B10 to NNAL- N-glucuronidation, the UGT2B10 genotype does not play a large role in NNAL detoxication. | Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers.
Murphy SE, von Weymarn LB, Parenteau M, Stepanov I, Tiirikainen M, LeMarchand L, Park SL., Free PMC Article | 02/16/2019 |
| UGT2B10 was for the first time identified as an N-glucosidation enzyme. Generated N-glucosides were excreted primarily by the BCRP transporter. | Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter.
Lu D, Dong D, Xie Q, Li Z, Wu B. | 11/17/2018 |
| A significant contribution of AS in the regulation of UGT2B10 expression in the liver. | Post-transcriptional Regulation of UGT2B10 Hepatic Expression and Activity by Alternative Splicing.
Labriet A, Allain EP, Rouleau M, Audet-Delage Y, Villeneuve L, Guillemette C., Free PMC Article | 11/10/2018 |
| UGT2B10 activity or genotype should be considered when using cotinine as a tobacco exposure biomarker, particularly in populations such as African American with high frequencies of UGT2B10 nonfunctional variants. | Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers.
Murphy SE, Sipe CJ, Choi K, Raddatz LM, Koopmeiners JS, Donny EC, Hatsukami DK., Free PMC Article | 04/14/2018 |
| Spatial features influence the potency of UGT2B10 inhibition. | Human UDP-Glucuronosyltransferase (UGT) 2B10: Validation of Cotinine as a Selective Probe Substrate, Inhibition by UGT Enzyme-Selective Inhibitors and Antidepressant and Antipsychotic Drugs, and Structural Determinants of Enzyme Inhibition.
Pattanawongsa A, Nair PC, Rowland A, Miners JO. | 10/29/2016 |
| UGT2B10 variant allele carriers had increased levels of C-oxidation (P = 0.0099)and all pathways should be considered when characterizing the role of nicotine metabolism on smoking behavior and cancer risk. | Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups.
Murphy SE, Park SS, Thompson EF, Wilkens LR, Patel Y, Stram DO, Le Marchand L., Free PMC Article | 03/21/2015 |
| CYP2A6 and UGT2B10 genotype explain 53% of the variance in oral nicotine glucuronidation. They are also significantly associated with undeuterated (D0) nicotine glucuronidation in individuals smoking ad libitum. | The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans.
Bloom AJ, von Weymarn LB, Martinez M, Bierut LJ, Goate A, Murphy SE., Free PMC Article | 05/17/2014 |
| the substrate specificity of UGT2B10, highlighting its preference for tertiary amines with higher affinities and clearance values than those of UGT1A4 and UGT1A3. | Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.
Kato Y, Izukawa T, Oda S, Fukami T, Finel M, Yokoi T, Nakajima M. | 11/30/2013 |
| UGT2B17 and UGT2B10 play key roles in the glucuronidation of 3HC in the human liver and that functional polymorphisms in UGT2B17 and UGT2B10 are associated with significantly reduced glucuronidation activities against 3HC. | Glucuronidation of trans-3'-hydroxycotinine by UGT2B17 and UGT2B10.
Chen G, Giambrone NE, Lazarus P., Free PMC Article | 08/4/2012 |
| Data show that UGT2B10 predicts MD independently of age, hormone therapy and parity. | Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density.
Haakensen VD, Biong M, Lingjærde OC, Holmen MM, Frantzen JO, Chen Y, Navjord D, Romundstad L, Lüders T, Bukholm IK, Solvang HK, Kristensen VN, Ursin G, Børresen-Dale AL, Helland A., Free PMC Article | 03/5/2011 |
| Data suggest that UGTs 2B10 and 2B17 play important roles in the glucuronidation of nicotine and suggest that the UGT2B10 codon 67 SNP and the UGT2B17 gene deletion reduce overall glucuronidation rates of nicotine and its major metabolites in smokers. | Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms.
Chen G, Giambrone NE Jr, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P, Chen G, Giambrone NE Jr, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P., Free PMC Articles: PMC2998997, PMC2998997 | 11/27/2010 |
| UGT2B10 genotype influences nicotine metabolism and should be taken into account when characterizing the role of nicotine metabolism on smoking. | UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption.
Berg JZ, von Weymarn LB, Thompson EA, Wickham KM, Weisensel NA, Hatsukami DK, Murphy SE, Berg JZ, von Weymarn LB, Thompson EA, Wickham KM, Weisensel NA, Hatsukami DK, Murphy SE., Free PMC Articles: PMC2882998, PMC2882998 | 10/23/2010 |
| The UGT2B10(67Tyr) variant corresponding to haplotype C is a functional single nucleotide polymorphism that may be responsible for inter individual variation in NNAL-N-glucuronidation activity and may increase susceptibility to smoking-related cancers. | Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines.
Chen G, Dellinger RW, Gallagher CJ, Sun D, Lazarus P, Chen G, Dellinger RW, Gallagher CJ, Sun D, Lazarus P. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGlucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms.
Chen G, Giambrone NE Jr, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P, Chen G, Giambrone NE Jr, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P. UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption.
Berg JZ, von Weymarn LB, Thompson EA, Wickham KM, Weisensel NA, Hatsukami DK, Murphy SE, Berg JZ, von Weymarn LB, Thompson EA, Wickham KM, Weisensel NA, Hatsukami DK, Murphy SE. Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines.
Chen G, Dellinger RW, Gallagher CJ, Sun D, Lazarus P, Chen G, Dellinger RW, Gallagher CJ, Sun D, Lazarus P. | 04/3/2008 |
| Data suggest that UGT2B10 is the major hepatic enzyme involved in nicotine/cotinine glucuronidation and that the UGT2B10*2 variant reduces nicotine- and cotinine-N-glucuronidation formation and plays a role in nicotine metabolism and elimination. | Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.
Chen G, Blevins-Primeau AS, Dellinger RW, Muscat JE, Lazarus P. | 01/21/2010 |
| Nicotine glucuronidation and UGT2B10 is reported. | Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.
Kaivosaari S, Toivonen P, Hesse LM, Koskinen M, Court MH, Finel M. | 01/21/2010 |