| Club cell protein (CC16) in serum as an effect marker for small airway epithelial damage caused by diesel exhaust and blasting fumes in potash mining. | Club cell protein (CC16) in serum as an effect marker for small airway epithelial damage caused by diesel exhaust and blasting fumes in potash mining.
Neumann S, Casjens S, Hoffmeyer F, Rühle K, Gamrad-Streubel L, Haase LM, Rudolph KK, Giesen J, Neumann V, Taeger D, Pallapies D, Birk T, Brüning T, Bünger J., Free PMC Article | 02/22/2024 |
| CC16 drives VLA-2-dependent SPLUNC1 expression. | CC16 drives VLA-2-dependent SPLUNC1 expression.
Iannuzo N, Welfley H, Li NC, Johnson MDL, Rojas-Quintero J, Polverino F, Guerra S, Li X, Cusanovich DA, Langlais PR, Ledford JG., Free PMC Article | 12/15/2023 |
| Circulating CC16 and Asthma: A Population-based, Multicohort Study from Early Childhood through Adult Life. | Circulating CC16 and Asthma: A Population-based, Multicohort Study from Early Childhood through Adult Life.
Voraphani N, Stern DA, Ledford JG, Spangenberg AL, Zhai J, Wright AL, Morgan WJ, Kraft M, Sherrill DL, Curtin JA, Murray CS, Custovic A, Kull I, Hallberg J, Bergström A, Herrera-Luis E, Halonen M, Martinez FD, Simpson A, Melén E, Guerra S., Free PMC Article | 10/11/2023 |
| Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. | Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Meyers DA, Bleecker ER., Free PMC Article | 03/10/2023 |
| Club cell 10-kDa protein (CC10) as a surrogate for identifying type 2 asthma phenotypes. | Club cell 10-kDa protein (CC10) as a surrogate for identifying type 2 asthma phenotypes.
Wang M, Tang K, Gao P, Lu Y, Wang S, Wu X, Zhao J, Xie J. | 02/27/2023 |
| CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study. | CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study.
Gribben KC, Wyss AB, Poole JA, Farazi PA, Wichman C, Richards-Barber M, Beane Freeman LE, Henneberger PK, Umbach DM, London SJ, LeVan TD., Free PMC Article | 11/19/2022 |
| Brief Research Report: Serum clara cell 16 kDa protein levels are increased in patients hospitalized for severe SARS-CoV-2 or sepsis infection. | Brief Research Report: Serum clara cell 16 kDa protein levels are increased in patients hospitalized for severe SARS-CoV-2 or sepsis infection.
Rohmann N, Stürmer P, Geisler C, Schlicht K, Hartmann K, Türk K, Hollstein T, Tran F, Rosenstiel P, Franke A, Heyckendorf J, Schreiber S, Schulte DM, Laudes M., Free PMC Article | 11/5/2022 |
| Urinary CC16, a potential indicator of lung integrity and inflammation, increases in children after short-term exposure to PM2.5/PM10 and is driven by the CC16 38GG genotype. | Urinary CC16, a potential indicator of lung integrity and inflammation, increases in children after short-term exposure to PM(2.5)/PM(10) and is driven by the CC16 38GG genotype.
Nauwelaerts SJD, Van Goethem N, Ureña BT, De Cremer K, Bernard A, Saenen ND, Nawrot TS, Roosens NHC, De Keersmaecker SCJ. | 06/25/2022 |
| Roles of Clara cell 10-kD protein and type 2 innate lymphoid cells in allergic rhinitis. | Roles of Clara cell 10-kD protein and type 2 innate lymphoid cells in allergic rhinitis.
Long X, Wang N, Zhang X., Free PMC Article | 03/26/2022 |
| A rapid point of care CC16 kit for screening of occupational silica dust exposed workers for early detection of silicosis/silico-tuberculosis. | A rapid point of care CC16 kit for screening of occupational silica dust exposed workers for early detection of silicosis/silico-tuberculosis.
Nandi SS, Lambe UP, Sarkar K, Sawant S, Deshpande J., Free PMC Article | 01/29/2022 |
| The relationship between the expression of serum IL-18 mRNA, CC16, and sTREM-1 and the severity and prognosis of ventilator-associated pneumonia in elderly patients. | The relationship between the expression of serum IL-18 mRNA, CC16, and sTREM-1 and the severity and prognosis of ventilator-associated pneumonia in elderly patients.
Wang J, Zhao Y, Pan L, He X, Zhang X. | 01/22/2022 |
| Clara cell 16 KDa protein mitigates house dust mite-induced airway inflammation and damage via regulating airway epithelial cell apoptosis in a manner dependent on HMGB1-mediated signaling inhibition. | Clara cell 16 KDa protein mitigates house dust mite-induced airway inflammation and damage via regulating airway epithelial cell apoptosis in a manner dependent on HMGB1-mediated signaling inhibition.
Liu M, Lu J, Zhang Q, Zhang Y, Guo Z., Free PMC Article | 10/2/2021 |
| Gender-dependent association between exhaled nitric oxide and the CC16 38AA genotype in young school children. | Gender-dependent association between exhaled nitric oxide and the CC16 38AA genotype in young school children.
Nauwelaerts SJD, Roosens NHC, De Cremer K, Bernard A, De Keersmaecker SCJ., Free PMC Article | 09/25/2021 |
| Clinical significance of CC16 and IL-12 in bronchoalveolar lavage fluid of various stages of silicosis. | Clinical significance of CC16 and IL-12 in bronchoalveolar lavage fluid of various stages of silicosis.
Zhang S, Jia Q, Song J, Tan Q, Yu G, Guo X, Zhang H. | 06/26/2021 |
| Renal dysfunction reduces the diagnostic and prognostic value of serum CC16 for acute respiratory distress syndrome in intensive care patients. | Renal dysfunction reduces the diagnostic and prognostic value of serum CC16 for acute respiratory distress syndrome in intensive care patients.
Lin J, Tao W, Wei J, Wu J, Zhang W, Ye J, Fu X, Zeng S, Dou Q, Wang L, Tian F., Free PMC Article | 05/29/2021 |
| Club cell protein 16 as a biomarker for early detection of silicosis. | Club cell protein 16 as a biomarker for early detection of silicosis.
Naha N, Muhamed JCJ, Pagdhune A, Sarkar B, Sarkar K., Free PMC Article | 05/8/2021 |
| Club cell 10-kDa protein (CC10) inhibits cPLA2/COX2 pathway to alleviate RSV-induced airway inflammation and AHR. | Club cell 10-kDa protein (CC10) inhibits cPLA2/COX2 pathway to alleviate RSV-induced airway inflammation and AHR.
Yu G, Mo S, Gao L, Wen X, Chen S, Long X, Xie X, Deng Y, Ren L, Zang N, Chen S, Liu E. | 03/13/2021 |
| Reduced Serum Concentration of CC16 Is Associated with Severity of Chronic Obstructive Pulmonary Disease and Contributes to the Diagnosis and Assessment of the Disease. | Reduced Serum Concentration of CC16 Is Associated with Severity of Chronic Obstructive Pulmonary Disease and Contributes to the Diagnosis and Assessment of the Disease.
Rong B, Fu T, Gao W, Li M, Rong C, Liu W, Liu H., Free PMC Article | 02/13/2021 |
| Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study. | Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study.
Milne S, Li X, Hernandez Cordero AI, Yang CX, Cho MH, Beaty TH, Ruczinski I, Hansel NN, Bossé Y, Brandsma CA, Sin DD, Obeidat M. | 12/26/2020 |
| Evaluated how secretoglobin family 1A member 1 (CC16), (which is present in sera from traumatized patients with or without pneumonia) will modify the functions of neutrophils. Results suggest an association of CC16 with C-X-C motif chemokine receptor 1 (CXCR1) and C-X-C motif chemokine receptor 2 (CXCR2.) | Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2.
Xu B, Janicova A, Vollrath JT, Störmann P, Martin L, Marzi I, Wutzler S, Hildebrand F, Ehnert S, Relja B., Free PMC Article | 07/11/2020 |
| People with lower plasma CC16 concentration are more likely to suffer from airway inflammation when exposed to high levels of vanadium, nickel or antimony. | Plasma CC16 mediates the associations between urinary metals and fractional exhaled nitric oxide: A cross-sectional study.
Li W, Xiao L, Zhou Y, Wang D, Ma J, Xie L, Yang M, Zhu C, Wang B, Chen W. | 04/11/2020 |
| Allele-specific expression identified rs2509956 with its RELA gene as a novel long-distance cis-regulatory SNP for SCGB1A1, an important gene for multiple pulmonary diseases. | Allele-specific expression identified rs2509956 as a novel long-distance cis-regulatory SNP for SCGB1A1, an important gene for multiple pulmonary diseases.
Li XX, Peng T, Gao J, Feng JG, Wu DD, Yang T, Zhong L, Fu WP, Sun C. | 04/4/2020 |
| low levels of epithelial SCGB1A1 in asthma are caused by reduced FOXA2 expression. | The Club Cell Marker SCGB1A1 Downstream of FOXA2 is Reduced in Asthma.
Zhu L, An L, Ran D, Lizarraga R, Bondy C, Zhou X, Harper RW, Liao SY, Chen Y., Free PMC Article | 02/22/2020 |
| CC16 is a homodimeric pneumoprotein encoded by the SCGB1A1 gene and, although produced predominantly by club cells and nonciliated epithelial cells in the distal airways, it is easily detectable in the circulation. | Club Cell Secretory Protein Deficiency Leads to Altered Lung Function.
Zhai J, Insel M, Addison KJ, Stern DA, Pederson W, Dy A, Rojas-Quintero J, Owen CA, Sherrill DL, Morgan W, Wright AL, Halonen M, Martinez FD, Kraft M, Guerra S, Ledford JG., Free PMC Article | 11/23/2019 |
| Long-term exposure to silica dust may lead to a decrease in serum CC16 levels | [The effects of long-term exposure to silica dust on serum CC16 and KL-6 levels].
Liu J, Zhang R, Song HY, Xia Q, Zhao TT, Pan LP, Qian XL. | 10/5/2019 |