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    C5 complement C5 [ Homo sapiens (human) ]

    Gene ID: 727, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Complement Component C5a and Fungal Pathogen Induce Diverse Responses through Crosstalk between Transient Receptor Potential Channel (TRPs) Subtypes in Human Conjunctival Epithelial Cells.

    Complement Component C5a and Fungal Pathogen Induce Diverse Responses through Crosstalk between Transient Receptor Potential Channel (TRPs) Subtypes in Human Conjunctival Epithelial Cells.
    Rech L, Dietrich-Ntoukas T, Reinach PS, Brockmann T, Pleyer U, Mergler S., Free PMC Article

    10/7/2024
    Complement decay-accelerating factor inhibits inflammation-induced myopia development.

    Complement decay-accelerating factor inhibits inflammation-induced myopia development.
    Chou YL, Hsu YA, Lin CF, Chen CS, Tien PT, Wang YC, Chang CY, Lin ES, Chen JJ, Wu MY, Chuang CY, Lin HJ, Wan L.

    06/21/2024
    Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis in Chinese Children.

    Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis in Chinese Children.
    Yu M, Yang Y, Zhang J, Liu R, Huang L, Wu J, Kang Z, Zhou J, Yang Z.

    03/25/2024
    Differential contributions of the C5b-9 and C5a/C5aR pathways to microvascular and macrovascular thrombosis in complement-mediated thrombotic microangiopathy patients.

    Differential contributions of the C5b-9 and C5a/C5aR pathways to microvascular and macrovascular thrombosis in complement-mediated thrombotic microangiopathy patients.
    Liu X, Hu Y, Yu X, Tan Y, Yu F, Chen M, Zhao M.

    02/1/2024
    A Transcriptome Array-Based Approach to Link SGLT-2 and Intrarenal Complement C5 Synthesis in Diabetic Nephropathy.

    A Transcriptome Array-Based Approach to Link SGLT-2 and Intrarenal Complement C5 Synthesis in Diabetic Nephropathy.
    Korsten P, Tampe B., Free PMC Article

    12/20/2023
    Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model.

    Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model.
    Bjerkhaug AU, Granslo HN, Cavanagh JP, Høiland I, Ludviksen JK, Lau C, Espevik T, Mollnes TE, Klingenberg C.

    08/1/2023
    Regulation of murine contact sensitivity to urushiol components by serum factors.

    Regulation of murine contact sensitivity to urushiol components by serum factors.
    Dunn IS, Liberato DJ, Stampf JL, Castagnoli N Jr, Byers VS.

    10/22/2022
    C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4d.

    C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4d.
    Kowalska D, Kuźniewska A, Senent Y, Tavira B, Inogés S, López-Díaz de Cerio A, Pio R, Okrój M, Yuste JR., Free PMC Article

    10/1/2022
    Elevated Adipsin and Reduced C5a Levels in the Maternal Serum and Follicular Fluid During Implantation Are Associated With Successful Pregnancy in Obese Women.

    Elevated Adipsin and Reduced C5a Levels in the Maternal Serum and Follicular Fluid During Implantation Are Associated With Successful Pregnancy in Obese Women.
    Ramanjaneya M, Diboun I, Rizwana N, Dajani Y, Ahmed L, Butler AE, Almarzooqi TA, Shahata M, Al Bader MK, Elgassim E, Burjaq H, Atkin SL, Abou-Samra AB, Elrayess MA., Free PMC Article

    08/6/2022
    C5 and SRGAP3 Polymorphisms Are Linked to Paediatric Allergic Asthma in the Italian Population.

    C5 and SRGAP3 Polymorphisms Are Linked to Paediatric Allergic Asthma in the Italian Population.
    Messelodi D, Giuliani C, Cipriani F, Armuzzi S, di Palmo E, Garagnani P, Bertelli L, Astolfi A, Luiselli D, Ricci G, Pession A., Free PMC Article

    07/23/2022
    The C5a/C5aR1 Axis Contributes to the Pathogenesis of Acute Cystitis Through Enhancement of Adhesion and Colonization of Uropathogenic E. coli.

    The C5a/C5aR1 Axis Contributes to the Pathogenesis of Acute Cystitis Through Enhancement of Adhesion and Colonization of Uropathogenic E. coli.
    Wu KY, Cao B, Wang CX, Yang XL, Zhao SJ, Diao TY, Lin LR, Zhao GX, Zhou W, Yang JR, Li K., Free PMC Article

    04/30/2022
    Pseudomonas aeruginosa adaptation in cystic fibrosis patients increases C5a levels and promotes neutrophil recruitment.

    Pseudomonas aeruginosa adaptation in cystic fibrosis patients increases C5a levels and promotes neutrophil recruitment.
    Mateu-Borrás M, González-Alsina A, Doménech-Sánchez A, Querol-García J, Fernández FJ, Vega MC, Albertí S., Free PMC Article

    04/23/2022
    Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis.

    Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis.
    Ortiz-Espinosa S, Morales X, Senent Y, Alignani D, Tavira B, Macaya I, Ruiz B, Moreno H, Remírez A, Sainz C, Rodriguez-Pena A, Oyarbide A, Ariz M, Andueza MP, Valencia K, Teijeira A, Hoehlig K, Vater A, Rolfe B, Woodruff TM, Lopez-Picazo JM, Vicent S, Kochan G, Escors D, Gil-Bazo I, Perez-Gracia JL, Montuenga LM, Lambris JD, Ortiz de Solorzano C, Lecanda F, Ajona D, Pio R.

    02/26/2022
    Complement Factor C5a Is Increased in Blood of Patients with Abdominal Aortic Aneurysm and Has Prognostic Potential for Aneurysm Growth.

    Complement Factor C5a Is Increased in Blood of Patients with Abdominal Aortic Aneurysm and Has Prognostic Potential for Aneurysm Growth.
    Zagrapan B, Eilenberg W, Scheuba A, Klopf J, Brandau A, Story J, Dosch K, Hayden H, Domenig CM, Fuchs L, Schernthaner R, Ristl R, Huk I, Neumayer C, Brostjan C., Free PMC Article

    02/5/2022
    Chronic Disseminated Gonococcal Infection in a Japanese Man with Novel C5 Gene Mutation.

    Chronic Disseminated Gonococcal Infection in a Japanese Man with Novel C5 Gene Mutation.
    Ikeuchi K, Okamoto K, Inoue N, Okugawa S, Moriya K.

    01/29/2022
    Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism.

    Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism.
    Skjeflo EW, Brækkan SK, Ludviksen JK, Snir O, Hindberg K, Mollnes TE, Hansen JB.

    12/25/2021
    Dysregulation of complement system in HELLP syndrome.

    Dysregulation of complement system in HELLP syndrome.
    Chen S, Li Z, He Y, Chen Q.

    12/25/2021
    The significance of metalloproteinase 3 (MMP-3), chemokine CXC ligand 13 (CXCL-13) and complement component C5a in different stages of ANCA associated vasculitis.

    The significance of metalloproteinase 3 (MMP-3), chemokine CXC ligand 13 (CXCL-13) and complement component C5a in different stages of ANCA associated vasculitis.
    Rymarz A, Mosakowska M, Niemczyk S., Free PMC Article

    12/11/2021
    C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera.

    C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera.
    Silva de França F, Villas-Boas IM, Cogliati B, Woodruff TM, Reis EDS, Lambris JD, Tambourgi DV., Free PMC Article

    10/2/2021
    Complement C5 activation promotes type 2 diabetic kidney disease via activating STAT3 pathway and disrupting the gut-kidney axis.

    Complement C5 activation promotes type 2 diabetic kidney disease via activating STAT3 pathway and disrupting the gut-kidney axis.
    Li L, Wei T, Liu S, Wang C, Zhao M, Feng Y, Ma L, Lu Y, Fu P, Liu J., Free PMC Article

    09/18/2021
    Complement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage.

    Complement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage.
    van Dijk BJ, Meijers JCM, Kloek AT, Knaup VL, Rinkel GJE, Morgan BP, van der Kamp MJ, Osuka K, Aronica E, Ruigrok YM, van de Beek D, Brouwer M, Pekna M, Hol EM, Vergouwen MDI., Free PMC Article

    07/24/2021
    Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.

    Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients.
    Karasu E, Demmelmaier J, Kellermann S, Holzmann K, Köhl J, Schmidt CQ, Kalbitz M, Gebhard F, Huber-Lang MS, Halbgebauer R., Free PMC Article

    04/24/2021
    Complement Regulation in Human Tenocytes under the Influence of Anaphylatoxin C5a.

    Complement Regulation in Human Tenocytes under the Influence of Anaphylatoxin C5a.
    Silawal S, Kohl B, Shi J, Schulze-Tanzil G., Free PMC Article

    04/24/2021
    Complement protein levels and MBL2 polymorphisms are associated with dengue and disease severity.

    Complement protein levels and MBL2 polymorphisms are associated with dengue and disease severity.
    Giang NT, van Tong H, Quyet D, Hoan NX, Nghia TH, Nam NM, Hung HV, Anh DT, Van Mao C, Son HA, Meyer CG, Velavan TP, Toan NL., Free PMC Article

    12/19/2020
    The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics.

    The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics.
    Woodruff TM, Shukla AK., Free PMC Article

    11/28/2020
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