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    Mir378a microRNA 378a [ Mus musculus (house mouse) ]

    Gene ID: 723889, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2.

    MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2.
    Wang G, Feng L, Liu C, Han Z, Chen X.

    10/2/2024
    Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia.

    Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia.
    Florczyk-Soluch U, Polak K, Sabo R, Martyniak A, Stępniewski J, Dulak J., Free PMC Article

    03/15/2024
    miR-378 influences muscle satellite cells and enhances adipogenic potential of fibro-adipogenic progenitors but does not affect muscle regeneration in the glycerol-induced injury model.

    miR-378 influences muscle satellite cells and enhances adipogenic potential of fibro-adipogenic progenitors but does not affect muscle regeneration in the glycerol-induced injury model.
    Mucha O, Podkalicka P, Żukowska M, Pośpiech E, Dulak J, Łoboda A., Free PMC Article

    08/25/2023
    LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis.

    LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis.
    Bhandari R, Shaikh II, Bhandari R, Chapagain S.

    06/16/2023
    MicroRNA-378 inhibits hepatocyte apoptosis during acute liver failure by targeting caspase-9 in mice.

    MicroRNA-378 inhibits hepatocyte apoptosis during acute liver failure by targeting caspase-9 in mice.
    Feng Z, Bao S, Kong L, Chen X.

    02/11/2023
    MiR-378a-3p/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure.

    MiR-378a-3p/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure.
    Wang W, Shi F, Cui J, Pang S, Zheng G, Zhang Y.

    08/13/2022
    miR-378 affects metabolic disturbances in the mdx model of Duchenne muscular dystrophy.

    miR-378 affects metabolic disturbances in the mdx model of Duchenne muscular dystrophy.
    Podkalicka P, Mucha O, Kaziród K, Szade K, Stępniewski J, Ivanishchuk L, Hirao H, Pośpiech E, Józkowicz A, Kupiec-Weglinski JW, Dulak J, Łoboda A., Free PMC Article

    07/23/2022
    Mechanism of miR-378a-3p enriched in M2 macrophage-derived extracellular vesicles in cardiomyocyte pyroptosis after MI.

    Mechanism of miR-378a-3p enriched in M2 macrophage-derived extracellular vesicles in cardiomyocyte pyroptosis after MI.
    Yuan W, Liang X, Liu Y, Wang H.

    04/23/2022
    MiR-378a-3p as a putative biomarker for hepatocellular carcinoma diagnosis and prognosis: Computational screening with experimental validation.

    MiR-378a-3p as a putative biomarker for hepatocellular carcinoma diagnosis and prognosis: Computational screening with experimental validation.
    Qian F, Wang J, Wang Y, Gao Q, Yan W, Lin Y, Shen L, Xie Y, Jiang X, Shen B., Free PMC Article

    12/25/2021
    Regulatory Action of Plasma from Patients with Obesity and Diabetes towards Muscle Cells Differentiation and Bioenergetics Revealed by the C2C12 Cell Model and MicroRNA Analysis.

    Regulatory Action of Plasma from Patients with Obesity and Diabetes towards Muscle Cells Differentiation and Bioenergetics Revealed by the C2C12 Cell Model and MicroRNA Analysis.
    Khromova NV, Fedorov AV, Ma Y, Kondratov KA, Prikhodko SS, Ignatieva EV, Artemyeva MS, Anopova AD, Neimark AE, Kostareva AA, Babenko AY, Dmitrieva RI., Free PMC Article

    09/25/2021
    hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis.

    hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis.
    Cai X, Zhang ZY, Yuan JT, Ocansey DKW, Tu Q, Zhang X, Qian H, Xu WR, Qiu W, Mao F., Free PMC Article

    09/18/2021
    Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis.

    Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis.
    Sun C, Liu W, Lu Z, Li Y, Liu S, Tang Z, Yan Y, Li Z, Feng H, Zhang D, Liu Y, Fang ZZ, Jiang C, Ding Q, Jiang J, Ying H., Free PMC Article

    07/31/2021
    The protective function of miR-378 in the ischemia-reperfusion injury during renal transplantation and subsequent interstitial fibrosis of the renal allograft.

    The protective function of miR-378 in the ischemia-reperfusion injury during renal transplantation and subsequent interstitial fibrosis of the renal allograft.
    Xiong L, Ding S, Yang T.

    05/22/2021
    Activation of microRNA-378a-3p biogenesis promotes hepatic secretion of VLDL and hyperlipidemia by modulating ApoB100-Sortilin1 axis.

    Activation of microRNA-378a-3p biogenesis promotes hepatic secretion of VLDL and hyperlipidemia by modulating ApoB100-Sortilin1 axis.
    Zhang T, Shi H, Liu N, Tian J, Zhao X, Steer CJ, Han Q, Song G., Free PMC Article

    05/22/2021
    Lack of miR-378 attenuates muscular dystrophy in mdx mice.

    Lack of miR-378 attenuates muscular dystrophy in mdx mice.
    Podkalicka P, Mucha O, Bronisz-Budzyńska I, Kozakowska M, Pietraszek-Gremplewicz K, Cetnarowska A, Głowniak-Kwitek U, Bukowska-Strakova K, Cieśla M, Kulecka M, Ostrowski J, Mikuła M, Potulska-Chromik A, Kostera-Pruszczyk A, Józkowicz A, Łoboda A, Dulak J., Free PMC Article

    05/22/2021
    miR-378-3p maintains the size of mouse primordial follicle pool by regulating cell autophagy and apoptosis.

    miR-378-3p maintains the size of mouse primordial follicle pool by regulating cell autophagy and apoptosis.
    Sun X, Klinger FG, Liu J, De Felici M, Shen W, Sun X., Free PMC Article

    05/1/2021
    miR-378a-3p Participates in Metformin's Mechanism of Action on C2C12 Cells under Hyperglycemia.

    miR-378a-3p Participates in Metformin's Mechanism of Action on C2C12 Cells under Hyperglycemia.
    Machado IF, Teodoro JS, Castela AC, Palmeira CM, Rolo AP., Free PMC Article

    04/3/2021
    Morphine modulates the expression of mu-opioid receptor exon 5-associated full-length C-terminal splice variants by upregulating miR-378a-3p.

    Morphine modulates the expression of mu-opioid receptor exon 5-associated full-length C-terminal splice variants by upregulating miR-378a-3p.
    Lu Z, Xu J, Wang Q, Pan YX., Free PMC Article

    03/27/2021
    CDK6 inhibition targeted by miR-378a-3p protects against intestinal injury induced by ionizing radiation.

    CDK6 inhibition targeted by miR-378a-3p protects against intestinal injury induced by ionizing radiation.
    Chu X, Zheng W, Wang J, Zhang J, Pan Y, Shao C.

    03/13/2021
    Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke.

    Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke.
    Luo HC, Yi TZ, Huang FG, Wei Y, Luo XP, Luo QS., Free PMC Article

    02/20/2021
    miR-378a influences vascularization in skeletal muscles.

    miR-378a influences vascularization in skeletal muscles.
    Krist B, Podkalicka P, Mucha O, Mendel M, Sępioł A, Rusiecka OM, Józefczuk E, Bukowska-Strakova K, Grochot-Przęczek A, Tomczyk M, Klóska D, Giacca M, Maga P, Niżankowski R, Józkowicz A, Łoboda A, Dulak J, Florczyk-Soluch U.

    02/13/2021
    miR-378 and its host gene Ppargc1beta exhibit independent expression in mouse skeletal muscle.

    miR-378 and its host gene Ppargc1β exhibit independent expression in mouse skeletal muscle.
    Kang L, Han C, Yang G, Li H, Li T, Yang S, Liang N, Zhong R, Jia L, Zhu D, Zhang Y.

    01/9/2021
    the study identifies a novel pro-fibrotic lncRNA, PCFL, and the mechanism involves the direct interaction of PCFL with miR-378, which in turn relieves the inhibition effect of miR-378 on GRB2 and promotes cardiac fibrosis.

    LncRNA PCFL promotes cardiac fibrosis via miR-378/GRB2 pathway following myocardial infarction.
    Sun F, Zhuang Y, Zhu H, Wu H, Li D, Zhan L, Yang W, Yuan Y, Xie Y, Yang S, Luo S, Jiang W, Zhang J, Pan Z, Lu Y.

    06/27/2020
    results indicated miR-378a impairs tenogenic differentiation and tendon repair by inhibition collagen and extracellular matrix production both in vitro and in vivo. We also demonstrated that miR-378a exert its inhibitory role during tenogenic differentiation through binding at TGFbeta2 by luciferase reporter assay and western blot.

    MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2.
    Liu Y, Feng L, Xu J, Yang Z, Wu T, Zhang J, Shi L, Zhu D, Zhang J, Li G., Free PMC Article

    06/27/2020
    LXRalpha selectively activates transcription of miR-378 and inhibits expression of Ppargc1beta, which synergistically impairs fatty acid oxidation (FAO). In addition to lipogenesis, impaired FAO by miR-378 contributes to LXRalpha-induced hepatosteatosis.

    LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA-378 Transcription and Inhibition of Ppargc1β Expression.
    Zhang T, Duan J, Zhang L, Li Z, Steer CJ, Yan G, Song G., Free PMC Article

    05/30/2020
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