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    Mir494 microRNA 494 [ Mus musculus (house mouse) ]

    Gene ID: 723878, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    [LncRNA SNHG8 inhibits miR-494-3p expression to alleviate cerebral ischemia-reperfusion injury in mice].

    [LncRNA SNHG8 inhibits miR-494-3p expression to alleviate cerebral ischemia-reperfusion injury in mice].
    Cao T, Liu Q, Pan M, Zhang X., Free PMC Article

    01/10/2024
    MiR-494-3p aggravates pirarubicin-induced cardiomyocyte injury by regulating MDM4/p53 signaling pathway.

    MiR-494-3p aggravates pirarubicin-induced cardiomyocyte injury by regulating MDM4/p53 signaling pathway.
    Huang P, Zhang Y, Wang F, Qin M, Ma J, Ji J, Wei D, Ren L.

    09/20/2023
    MiR-494-mediated Effects on the NF-kappaB Signaling Pathway Regulate Lipopolysaccharide-Induced Acute Kidney Injury in Mice.

    MiR-494-mediated Effects on the NF-κB Signaling Pathway Regulate Lipopolysaccharide-Induced Acute Kidney Injury in Mice.
    Lu P, Zhang L, Liu T, Fan JJ, Luo X, Zhu YT.

    07/23/2022
    Linoleic Acid Upregulates Microrna-494 to Induce Quiescence in Colorectal Cancer.

    Linoleic Acid Upregulates Microrna-494 to Induce Quiescence in Colorectal Cancer.
    Ogata R, Mori S, Kishi S, Sasaki R, Iwata N, Ohmori H, Sasaki T, Nishiguchi Y, Nakashima C, Goto K, Kawahara I, Fujiwara-Tani R, Kuniyasu H., Free PMC Article

    02/5/2022
    MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation by inhibiting proliferation and inducing apoptosis through targeting TRAF3.

    MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation by inhibiting proliferation and inducing apoptosis through targeting TRAF3.
    Li H, Zhang L, Cai N, Zhang B, Sun S.

    01/15/2022
    Long non-coding RNA MALAT1 enhances angiogenesis during bone regeneration by regulating the miR-494/SP1 axis.

    Long non-coding RNA MALAT1 enhances angiogenesis during bone regeneration by regulating the miR-494/SP1 axis.
    Ding A, Li CH, Yu CY, Zhou HT, Zhang ZH.

    01/1/2022
    Regulation mechanism of miR-494-3p on endometrial receptivity in mice via PI3K/AKT/mTOR pathway.

    Regulation mechanism of miR-494-3p on endometrial receptivity in mice via PI3K/AKT/mTOR pathway.
    Yuan L, Feng F, Mao Z, Huang JZ, Liu Y, Li YL, Jiang RX.

    10/9/2021
    MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells.

    MicroRNA-494-3p inhibits formation of fast oxidative muscle fibres by targeting E1A-binding protein p300 in human-induced pluripotent stem cells.
    Iwasaki H, Ichihara Y, Morino K, Lemecha M, Sugawara L, Sawano T, Miake J, Sakurai H, Nishi E, Maegawa H, Imamura T., Free PMC Article

    08/14/2021
    Dendritic cellderived exosomal miR4943p promotes angiogenesis following myocardial infarction.

    Dendritic cell‑derived exosomal miR‑494‑3p promotes angiogenesis following myocardial infarction.
    Liu H, Zhang Y, Yuan J, Gao W, Zhong X, Yao K, Lin L, Ge J., Free PMC Article

    07/17/2021
    Silencing of microRNA-494 inhibits the neurotoxic Th1 shift via regulating HDAC2-STAT4 cascade in ischaemic stroke.

    Silencing of microRNA-494 inhibits the neurotoxic Th1 shift via regulating HDAC2-STAT4 cascade in ischaemic stroke.
    Zhao H, Li G, Wang R, Tao Z, Ma Q, Zhang S, Han Z, Yan F, Li F, Liu P, Ma S, Ji X, Luo Y., Free PMC Article

    04/13/2021
    Downregulation of MicroRNA-494 inhibits the TGF-beta1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L.

    Downregulation of MicroRNA-494 inhibits the TGF-β1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L.
    Tian RH, Guo KM, Han GH, Bai Y.

    10/31/2020
    MicroRNA-494-3p alleviates inflammatory response in sepsis by targeting TLR6.

    MicroRNA-494-3p alleviates inflammatory response in sepsis by targeting TLR6.
    Wang HF, Li Y, Wang YQ, Li HJ, Dou L.

    09/12/2020
    Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy.

    Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy.
    Costantino S, Akhmedov A, Melina G, Mohammed SA, Othman A, Ambrosini S, Wijnen WJ, Sada L, Ciavarella GM, Liberale L, Tanner FC, Matter CM, Hornemann T, Volpe M, Mechta-Grigoriou F, Camici GG, Sinatra R, Lüscher TF, Paneni F.

    08/22/2020
    pivotal role in bone formation by negatively regulating osteogenetic differentiation

    Mir-494 inhibits osteoblast differentiation by regulating BMP signaling in simulated microgravity.
    Qin W, Liu L, Wang Y, Wang Z, Yang A, Wang T.

    05/30/2020
    In vitro studies confirmed that miR-494 posttranslationally inhibited HDAC3 in neurons and prevented OGD-induced neuronal axonal injury.

    Inhibition of histone deacetylase 3 by MiR-494 alleviates neuronal loss and improves neurological recovery in experimental stroke.
    Zhao H, Li G, Zhang S, Li F, Wang R, Tao Z, Ma Q, Han Z, Yan F, Fan J, Li L, Ji X, Luo Y., Free PMC Article

    05/9/2020
    Our findings demonstrate that decreased miR-494-3p expression during browning regulates mitochondrial biogenesis and thermogenesis through PGC1-alpha.

    MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes.
    Lemecha M, Morino K, Imamura T, Iwasaki H, Ohashi N, Ida S, Sato D, Sekine O, Ugi S, Maegawa H., Free PMC Article

    10/26/2019
    Transfection with miR494 mimics decreased VSMC apoptosis and downregulated BCL2L11 protein levels. Conversely, transfection with miR494 inhibitors increased cell apoptosis and upregulated BCL2L11 protein levels, suggesting that miR494 may function as an essential regulator of BCL2L11.

    MicroRNA‑494 inhibits apoptosis of murine vascular smooth muscle cells in vitro.
    Cui R, Ye S, Zhong J, Liu L, Li S, Lin X, Yuan L, Yi L.

    08/3/2019
    These data indicated that miR-494-3p regulated inflammation by decreasing p65 translocation to the nucleus. This study also demonstrated that miR-494-3p was associated with suppressing immune responses by downregulating PTEN in RAW264.7 cells.

    miR‑494‑3p regulates lipopolysaccharide‑induced inflammatory responses in RAW264.7 cells by targeting PTEN.
    Zhang S, He K, Zhou W, Cao J, Jin Z., Free PMC Article

    08/3/2019
    miR-494-3p improves the ability of lung tumor cells to grow and metastasize by modulating NOTCH1 and PTEN/PI3K/AKT signaling.

    miR-494-3p is a novel tumor driver of lung carcinogenesis.
    Faversani A, Amatori S, Augello C, Colombo F, Porretti L, Fanelli M, Ferrero S, Palleschi A, Pelicci PG, Belloni E, Ercoli G, Degrassi A, Baccarin M, Altieri DC, Vaira V, Bosari S., Free PMC Article

    03/3/2018
    miR-494 and miR-696 are sensitive miRNAs in response to exercise training

    Voluntary wheel exercise alters the levels of miR-494 and miR-696 in the skeletal muscle of C57BL/6 mice.
    Sun Y, Cui D, Zhang Z, Zhang Q, Ji L, Ding S.

    02/4/2017
    miR-494 is a novel tumor-derived paracrine signal to promote angiogenesis and tumor growth under hypoxic condition

    Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer.
    Mao G, Liu Y, Fang X, Liu Y, Fang L, Lin L, Liu X, Wang N.

    04/9/2016
    Inhibition of miR-494 may decrease the risk of surgical complications or even avert endarterectomy surgery in some cases.

    Inhibition of MicroRNA-494 Reduces Carotid Artery Atherosclerotic Lesion Development and Increases Plaque Stability.
    Wezel A, Welten SM, Razawy W, Lagraauw HM, de Vries MR, Goossens EA, Boonstra MC, Hamming JF, Kandimalla ER, Kuiper J, Quax PH, Nossent AY, Bot I.

    02/27/2016
    miR-142-3p and miR-494 may function as cis- and trans-acting signals contributing to local temporal coordination of cell-autonomous circadian clocks

    MicroRNAs function as cis- and trans-acting modulators of peripheral circadian clocks.
    Shende VR, Kim SM, Neuendorff N, Earnest DJ.

    10/18/2014
    the present study concludes that the upregulation of miR-494 expression by TNF-alpha-mediated inflammation exacerbates insulin resistance.

    MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells.
    Lee H, Jee Y, Hong K, Hwang GS, Chun KH., Free PMC Article

    10/4/2014
    Data suggest that miR-494 regulates mitochondrial biogenesis by down-regulating mtTFA (mitochondrial transcription factor A) and Foxj3 (forkhead box J3 protein) during myocyte differentiation and skeletal muscle adaptation to physical exercise.

    MicroRNA-494 regulates mitochondrial biogenesis in skeletal muscle through mitochondrial transcription factor A and Forkhead box j3.
    Yamamoto H, Morino K, Nishio Y, Ugi S, Yoshizaki T, Kashiwagi A, Maegawa H.

    03/2/2013
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