| Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease. | Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease.
Donkervoort S, van de Locht M, Ronchi D, Reunert J, McLean CA, Zaki M, Orbach R, de Winter JM, Conijn S, Hoomoedt D, Neto OLA, Magri F, Viaene AN, Foley AR, Gorokhova S, Bolduc V, Hu Y, Acquaye N, Napoli L, Park JH, Immadisetty K, Miles LB, Essawi M, McModie S, Ferreira LF, Zanotti S, Neuhaus SB, Medne L, ElBagoury N, Johnson KR, Zhang Y, Laing NG, Davis MR, Bryson-Richardson RJ, Hwee DT, Hartman JJ, Malik FI, Kekenes-Huskey PM, Comi GP, Sharaf-Eldin W, Marquardt T, Ravenscroft G, Bönnemann CG, Ottenheijm CAC. | 04/8/2024 |
| Elevation of fast but not slow troponin I in the circulation of patients with Becker and Duchenne muscular dystrophy. | Elevation of fast but not slow troponin I in the circulation of patients with Becker and Duchenne muscular dystrophy.
Barthel BL, Cox D, Barbieri M, Ziemba M, Straub V, Hoffman EP, Russell AJ., Free PMC Article | 09/4/2021 |
| Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study. | Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study.
Sanders RD, Craigova L, Schessler B, Casey C, White M, Parker M, Kunkel D, Blennow K, Zetterberg H, Pearce RA, Lennertz R., Free PMC Article | 04/3/2021 |
| Cardiac Troponin I Is an Independent Predictor for Mortality in Hospitalized Patients With COVID-19. | Cardiac Troponin I Is an Independent Predictor for Mortality in Hospitalized Patients With COVID-19.
Nie SF, Yu M, Xie T, Yang F, Wang HB, Wang ZH, Li M, Gao XL, Lv BJ, Wang SJ, Zhang XB, He SL, Qiu ZH, Liao YH, Zhou ZH, Cheng X., Free PMC Article | 09/5/2020 |
| Troponin I levels at intensive care unit admission are a strong independent predictor of dialysis needs in sepsis. | Troponin I at admission in the intensive care unit predicts the need of dialysis in septic patients.
de Almeida Thiengo D, Strogoff-de-Matos JP, Lugon JR, Graciano ML., Free PMC Article | 10/5/2019 |
| Studied use of serum levels of Troponin I as a predictive biomarker for diagnosis of left ventricular systolic dysfunction after anthracycline treatment in breast cancer. | Left Ventricular Systolic Dysfunction Predicted By Early Troponin I Release After Anthracycline Based Chemotherapy In Breast Cancer Patients.
Shafi A, Siddiqui N, Imtiaz S, Din Sajid MU. | 04/13/2019 |
| Ultrasensitive troponin I was detectable in almost all individuals of a study sample reflecting middle-aged to elderly European general population. Ultrasensitive troponin concentrations exhibit an independent, graded, positive relation with incident CHD [coronary heart disease]. | Ultra-sensitive troponin I is an independent predictor of incident coronary heart disease in the general population.
Kaess BM, de Las Heras Gala T, Zierer A, Meisinger C, Wahl S, Peters A, Todd J, Herder C, Huth C, Thorand B, Koenig W. | 03/17/2018 |
| Measuring mean platelet volume in conjunction with troponin I levels improves the diagnostic value of troponin I in acute coronary syndrome. | Diagnostic Value of Mean Platelet Volume Combined With Troponin I for Acute Coronary Syndrome.
Wang X, Xu XL, Li XM, Zhao R, Yang X, Cong HL. | 05/13/2017 |
| GDF-15, sST2, and hs-TnI are associated with incident cardiovascular disease and heart failure | Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study.
Andersson C, Enserro D, Sullivan L, Wang TJ, Januzzi JL Jr, Benjamin EJ, Vita JA, Hamburg NM, Larson MG, Mitchell GF, Vasan RS., Free PMC Article | 03/11/2017 |
| CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage. | The relationship between cardiotrophin-1 and troponin-i in coronary arterial bypass grafting on the beating heart: a prospective study.
Caliskan S, Besli F, Yildirim A, Gungoren F, Alisir MF, Polat U, Ozdemir B, Bicer M. | 12/17/2016 |
| Data suggest that mutation A162H in switch region of troponin I induces transitory curved conformation and promotes contraction of troponin I bound to regulatory domain of troponin C; this is countered by residue E164 to ensure proper relaxation. | Structure and Dynamics of the Acidosis-Resistant A162H Mutant of the Switch Region of Troponin I Bound to the Regulatory Domain of Troponin C.
Pineda-Sanabria SE, Robertson IM, Sykes BD. | 09/5/2015 |
| sTnI as a sensitive marker of skeletal muscle injury. | Serum skeletal troponin I following inspiratory threshold loading in healthy young and middle-aged men.
Foster GE, Nakano J, Sheel AW, Simpson JA, Road JD, Reid WD. | 07/6/2013 |
| Elevations of troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are common in patients with atrial fibrillation and independently related to increased risks of stroke and mortality. | Cardiac biomarkers are associated with an increased risk of stroke and death in patients with atrial fibrillation: a Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) substudy.
Hijazi Z, Oldgren J, Andersson U, Connolly SJ, Ezekowitz MD, Hohnloser SH, Reilly PA, Vinereanu D, Siegbahn A, Yusuf S, Wallentin L. | 05/19/2012 |
| Elevated post-operative troponin 1 levels predict long-term mortality in older patients undergoing emergency orthpedic surgery. | Impact of troponin 1 on long-term mortality after emergency orthopaedic surgery in older patients.
Chong C, Lam Q, Ryan J, Sinnappu R, Lim WK. | 10/1/2011 |
| Evaluated the prevalence of TNN13 gene mutations in sudden death caused by cardiomyopathy (CM); in dilated CM cases, a new missense mutation Pro16Thr was detected. A single nucleotide polymorphism at -8 position of intron 3 was identified. | Analysis of the sarcomere protein gene mutation on cardiomyopathy - Mutations in the cardiac troponin I gene.
Murakami C, Nakamura S, Kobayashi M, Maeda K, Irie W, Wada B, Hayashi M, Sasaki C, Nakamaru N, Furukawa M, Kurihara K. | 01/29/2011 |
| A revised method of troponin exchange in pemeabilized cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I. | A revised method of troponin exchange in permeabilised cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I.
Preston LC, Watkins H, Redwood CS. | 01/21/2010 |
| MEF2 activation of the troponin I slow enhancer is repressed by hMusTRD1alpha1 | hMusTRD1alpha1 represses MEF2 activation of the troponin I slow enhancer.
Polly P, Haddadi LM, Issa LL, Subramaniam N, Palmer SJ, Tay ES, Hardeman EC. | 01/21/2010 |
| troponin I phosphorylation has a role in protein kinase C-mediated enhanced contractile performance of myocytes | Role of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytes.
Westfall MV, Borton AR. | 01/21/2010 |
| These results suggest that this R21C mutation in TnI affects the Ca(2+)-sensitizing effect of Tn, the ability of TnI to be readily phosphorylated by PKA and the stability of TnI to calpain. | A mutation in the N-terminus of troponin I that is associated with hypertrophic cardiomyopathy affects the Ca(2+)-sensitivity, phosphorylation kinetics and proteolytic susceptibility of troponin.
Gomes AV, Harada K, Potter JD. | 01/21/2010 |
| Low expression of ssTnI was found in 60% of patients in sinus rhythm or paroxysmal AF and in 8% of patients with chronic AF. Relative ssTnI mRNA expression was significantly lower in patients with AF than in those in sinus rhythm. | Troponin I isoform expression in human and experimental atrial fibrillation.
Thijssen VL, Ausma J, Gorza L, van der Velden HM, Allessie MA, Van Gelder IC, Borgers M, van Eys GJ. | 01/21/2010 |
| a localized N-terminal region of TnI comprised of amino acids 33-80, which interacts with C-terminal regions of cTnC and cTnT, is of particular significance in transducing signaling of thin filament activation by strong cross-bridges | Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments.
Engel PL, Kobayashi T, Biesiadecki B, Davis J, Tikunova S, Wu S, Solaro RJ. | 01/21/2010 |