| PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression. | PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression.
Del Vecchio A, Mulé P, Fernández-Pérez D, Amato S, Lattanzi G, Zanotti M, Rustichelli S, Pivetti S, Oldani P, Mariani A, Iommazzo F, Koseki H, Facciotti F, Tamburri S, Ferrari KJ, Pasini D. | 02/13/2024 |
| Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis. | Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis.
Tanaskovic N, Dalsass M, Filipuzzi M, Ceccotti G, Verrecchia A, Nicoli P, Doni M, Olivero D, Pasini D, Koseki H, Sabò A, Bisso A, Amati B., Free PMC Article | 07/23/2022 |
| H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos. | H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos.
Mei H, Kozuka C, Hayashi R, Kumon M, Koseki H, Inoue A. | 04/24/2021 |
| The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters. | The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters.
Liu M, Zhu Y, Xing F, Liu S, Xia Y, Jiang Q, Qin J., Free PMC Article | 01/16/2021 |
| The authors findings highlight a novel mechanism of Pcgf6 protein in regulating stem cell pluripotency: PCGF6 is recruited to a subset of the super-enhancer (SE) regions upstream of cell cycle-associated genes by Oct4 (Octamer Transcription Factor-4) and increased their expression, also, PCGF6 activates cell cycle genes by regulating SE-promoter interactions via 3D chromatin. | PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions.
Huang X, Wei C, Li F, Jia L, Zeng P, Li J, Tan J, Sun T, Jiang S, Wang J, Tang X, Zhao Q, Liu B, Rong L, Li C, Ding J., Free PMC Article | 05/16/2020 |
| Pcgf6 acts as a master regulator to maintain embryonic stem cell identity. | Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity.
Yang CS, Chang KY, Dang J, Rana TM., Free PMC Article | 04/7/2018 |
| Conditional ablation of Pcgf6 in embryonic stem cells leads to robust de-repression of germ cell-related genes, in turn affecting cell growth and viability. | PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.
Endoh M, Endo TA, Shinga J, Hayashi K, Farcas A, Ma KW, Ito S, Sharif J, Endoh T, Onaga N, Nakayama M, Ishikura T, Masui O, Kessler BM, Suda T, Ohara O, Okuda A, Klose R, Koseki H., Free PMC Article | 01/6/2018 |
| The results identify two key regulators, PCGF6 and JARID1c that temper dendritic cells (DC) activation and implicate active transcriptional silencing via histone demethylation as a previously unappreciated mechanism for regulating DC activation and quiescence. | The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.
Boukhaled GM, Cordeiro B, Deblois G, Dimitrov V, Bailey SD, Holowka T, Domi A, Guak H, Chiu HH, Everts B, Pearce EJ, Lupien M, White JH, Krawczyk CM. | 11/18/2017 |
| Pcgf6 is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex | Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.
Zhao W, Tong H, Huang Y, Yan Y, Teng H, Xia Y, Jiang Q, Qin J., Free PMC Article | 07/8/2017 |
| that Pcgf6 is nonredundantly involved in maintaining the pluripotent nature of embryonic stem cells and it functions in induced pluripotent stem reprogramming | Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.
Zdzieblo D, Li X, Lin Q, Zenke M, Illich DJ, Becker M, Müller AM. | 12/5/2015 |
| regulation by cell cycle-dependent phosphorylation | MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation.
Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H. | 01/21/2010 |