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    TLR4 toll like receptor 4 [ Homo sapiens (human) ]

    Gene ID: 7099, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells.

    TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells.
    Landolina N, Ricci B, Veneziani I, Alicata C, Mariotti FR, Pelosi A, Quatrini L, Mortari EP, Carsetti R, Vacca P, Tumino N, Azzarone B, Moretta L, Maggi E., Free PMC Article

    10/18/2024
    Hepatitis B surface antigen impairs TLR4 signaling by upregulating A20 expression in monocytes.

    Hepatitis B surface antigen impairs TLR4 signaling by upregulating A20 expression in monocytes.
    Wang C, Huang C, Li Y, Bai J, Zhao K, Fang Z, Chen J., Free PMC Article

    10/10/2024
    Growth inhibition of subcutaneous tumor with glioma cells in nude mice by silencing TLR4.

    Growth inhibition of subcutaneous tumor with glioma cells in nude mice by silencing TLR4.
    An Z, Zheng C, Liu L, He Z, Yang X, Liu J, Tong J, Liu Y.

    10/9/2024
    Tropomodulin1 exacerbates inflammatory response in macrophages by negatively regulating LPS-induced TLR4 endocytosis.

    Tropomodulin1 exacerbates inflammatory response in macrophages by negatively regulating LPS-induced TLR4 endocytosis.
    Geng X, Xia X, Liang Z, Li S, Yue Z, Zhang H, Guo L, Ma S, Jiang S, Lian X, Zhou J, Sung LA, Wang X, Yao W., Free PMC Article

    09/23/2024
    S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling.

    S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling.
    Özbay Kurt FG, Cicortas BA, Balzasch BM, De la Torre C, Ast V, Tavukcuoglu E, Ak C, Wohlfeil SA, Cerwenka A, Utikal J, Umansky V., Free PMC Article

    09/21/2024
    TNFAIP3 Overexpression Inhibits Diffuse Large B-Cell Lymphoma Progression by Promoting Autophagy through TLR4/MyD88/NF-kappaB Signaling Pathway.

    TNFAIP3 Overexpression Inhibits Diffuse Large B-Cell Lymphoma Progression by Promoting Autophagy through TLR4/MyD88/NF-κB Signaling Pathway.
    Ning F, Wang H, Liang Z, Lan J.

    09/4/2024
    Differential expression and prognostic value of TLR4 in kidney renal clear cell carcinoma.

    Differential expression and prognostic value of TLR4 in kidney renal clear cell carcinoma.
    Hu Y, Gu Y, Song Y, Zhao Y, Wang J, Ma J, Sui F.

    08/22/2024
    The relationship between Toll-like receptor-4 genes and preeclampsia outcomes.

    The relationship between Toll-like receptor-4 genes and preeclampsia outcomes.
    Kurmanova A, Urazbayeva G, Salimbayeva D, Terlikbayeva A, Kypshakbayeva Z, Smailov M.,

    08/21/2024
    Association of TLR4 gene rs4986790 and rs4986791 polymorphisms with asthma susceptibility: meta-analysis and trial sequential analysis.

    Association of TLR4 gene rs4986790 and rs4986791 polymorphisms with asthma susceptibility: meta-analysis and trial sequential analysis.
    Guo N, Tian H, Song T, Peng Y., Free PMC Article

    08/16/2024
    Toll-Like Receptor mRNA Levels in Schizophrenia: Association With Complement Factors and Cingulate Gyrus Cortical Thinning.

    Toll-Like Receptor mRNA Levels in Schizophrenia: Association With Complement Factors and Cingulate Gyrus Cortical Thinning.
    Weickert TW, Ji E, Galletly C, Boerrigter D, Morishima Y, Bruggemann J, Balzan R, O'Donnell M, Liu D, Lenroot R, Weickert CS, Kindler J.,

    08/7/2024
    TLR4 Polymorphisms (T399I/D299G) Association with Schizophrenia and Bipolar Disorder in a Tunisian Population.

    TLR4 Polymorphisms (T399I/D299G) Association with Schizophrenia and Bipolar Disorder in a Tunisian Population.
    Aflouk Y, Saoud H, Inoubli O, Yacoub S, Zaafrane F, Gaha L, Bel Hadj Jrad B.

    07/31/2024
    RNF31 mediated ubiquitination of A20 aggravates inflammation and hepatocyte apoptosis through the TLR4/MyD88/NF-kappaB signaling pathway.

    RNF31 mediated ubiquitination of A20 aggravates inflammation and hepatocyte apoptosis through the TLR4/MyD88/NF-κB signaling pathway.
    Li S, Zheng X, Hu Y, You K, Wang J.

    07/29/2024
    TLR2 and TLR4 Are Expressed in Epiretinal Membranes: Possible Links with Vitreous Levels of Complement Fragments and DAMP-Related Proteins.

    TLR2 and TLR4 Are Expressed in Epiretinal Membranes: Possible Links with Vitreous Levels of Complement Fragments and DAMP-Related Proteins.
    Dinice L, Esposito G, Cacciamani A, Balzamino BO, Cosimi P, Cafiero C, Ripandelli G, Micera A., Free PMC Article

    07/29/2024
    TLR2 and TLR4 Polymorphisms Are Not Associated with Dental Caries in Polish Children.

    TLR2 and TLR4 Polymorphisms Are Not Associated with Dental Caries in Polish Children.
    Milona M, Olszowski T, Uzar I, Safranow K, Janiszewska-Olszowska J, Szmidt-Kądys M, Rola H, Sikora M, Chlubek D, Adler G., Free PMC Article

    07/18/2024
    TLR4 signalling: the key to controlling EV71 replication and inflammatory response.

    TLR4 signalling: the key to controlling EV71 replication and inflammatory response.
    Hao J, Wang H, Lu X, Li Z, Zhang X., Free PMC Article

    07/10/2024
    The relationship between the rs4986791 variant of the TLR4 gene and the severity of bronchial asthma in children.

    The relationship between the rs4986791 variant of the TLR4 gene and the severity of bronchial asthma in children.
    Chen X, Wang K, Yao Q, Peng L, Wei L.

    06/28/2024
    [H3K27 acetylation promotes lncRNA OIP5-AS1 transcription and induces apoptosis of nasal epithelial cells in allergic rhinitis through up-regulation of TLR4].

    [H3K27 acetylation promotes lncRNA OIP5-AS1 transcription and induces apoptosis of nasal epithelial cells in allergic rhinitis through up-regulation of TLR4].
    Xie Y, She Z, Li R, Wu R, Wang R, Liu J.

    06/24/2024
    Toll like receptor 4 mediates the inhibitory effect of SARS-CoV-2 spike protein on proximal tubule albumin endocytosis.

    Toll like receptor 4 mediates the inhibitory effect of SARS-CoV-2 spike protein on proximal tubule albumin endocytosis.
    Silva-Aguiar RP, Teixeira DE, Peruchetti DB, Peres RAS, Alves SAS, Calil PT, Arruda LB, Costa LJ, Silva PL, Schmaier AH, Rocco PRM, Pinheiro AAS, Caruso-Neves C.

    05/29/2024
    Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients.

    Correlation analysis of serum TLR4 protein levels and TLR4 gene polymorphisms in gouty arthritis patients.
    Liu L, He S, Jia L, Yao H, Zhou D, Guo X, Miao L., Free PMC Article

    05/20/2024
    Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis.

    Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis.
    Mattke J, Darden CM, Lawrence MC, Kuncha J, Shah YA, Kane RR, Naziruddin B., Free PMC Article

    04/12/2024
    Toll-like receptor-4 expression and oxidative stress in ocular rosacea.

    Toll-like receptor-4 expression and oxidative stress in ocular rosacea.
    Yesilirmak N, Bukan N, Kurt B, Fatsa T, Yuzbasıoglu S, Zhao M, Hosbul T, Bourges JL, Behar-Cohen F., Free PMC Article

    04/12/2024
    Impact of toll-like receptor 4 variations on nasopharyngeal carcinoma risk and survival in tunisian population.

    Impact of toll-like receptor 4 variations on nasopharyngeal carcinoma risk and survival in tunisian population.
    Ben Chaaben A, Ayadi I, Abaza H, Baroudi O, Douik H, Harzallah L, Bouassida J, Bouckouaci W, Guemira F, Mankai A, Kharrat M, Tamouza R., Free PMC Article

    04/8/2024
    TLR4 TIR domain and nucleolin GAR domain synergistically mediate RSV infection and induce neuronal inflammatory damage in SH-SY5Y cells.

    TLR4 TIR domain and nucleolin GAR domain synergistically mediate RSV infection and induce neuronal inflammatory damage in SH-SY5Y cells.
    Jiang C, Huang Y, Gui H, Liu X, Li H, Han M, Huang S.

    04/4/2024
    Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.

    Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.
    Ayari F, Chaaben AB, Abaza H, Mihoub O, Ouni N, Boukouaci W, Kharrat M, Leboyer M, Guemira F, Tamouza R, Mankai A.

    04/4/2024
    TNF-alpha promotes osteocyte necroptosis by upregulating TLR4 in postmenopausal osteoporosis.

    TNF-α promotes osteocyte necroptosis by upregulating TLR4 in postmenopausal osteoporosis.
    Cui H, Li J, Li X, Su T, Wen P, Wang C, Deng X, Fu Y, Zhao W, Li C, Hua P, Zhu Y, Wan W.

    04/2/2024
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