| TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation. | TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation.
Agarwal M, Bharadwaj A, Mathew SJ. | 03/12/2022 |
| Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population. | Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population.
Chen JB, Zhang J, Hu HZ, Xue M, Jin YJ. | 06/30/2018 |
| the loss of TLE4 confers proliferative advantage to leukemic cells, simultaneous with an upregulation of a pro- inflammatory signature mediated through aberrant increases in Wnt signaling activity | TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia.
Shin TH, Brynczka C, Dayyani F, Rivera MN, Sweetser DA., Free PMC Article | 07/29/2017 |
| the results suggested that TLE4, a potential prognostic biomarker for colorectal cancer, plays an important role in the development and progression of human colorectal cancer. | TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway.
Wang SY, Gao K, Deng DL, Cai JJ, Xiao ZY, He LQ, Jiao HL, Ye YP, Yang RW, Li TT, Liang L, Liao WT, Ding YQ., Free PMC Article | 11/12/2016 |
| PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. | The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.
Abraham S, Paknikar R, Bhumbra S, Luan D, Garg R, Dressler GR, Patel SR., Free PMC Article | 05/30/2015 |
| Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 gene induced by BMP7. | The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling.
Zhang P, Dressler GR., Free PMC Article | 05/3/2014 |
| Displacing coactivators CREB-binding protein/p300 while promoting the recruitment of a corepressor, Grg4. | SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest.
Lee PC, Taylor-Jaffe KM, Nordin KM, Prasad MS, Lander RM, LaBonne C., Free PMC Article | 02/9/2013 |
| Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation. | Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.
Patel SR, Bhumbra SS, Paknikar RS, Dressler GR., Free PMC Article | 04/7/2012 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
de Miguel-Yanes JM, Shrader P, Pencina MJ, Fox CS, Manning AK, Grant RW, Dupuis J, Florez JC, D'Agostino RB Sr, Cupples LA, Meigs JB, MAGIC Investigators, DIAGRAM+ Investigators., Free PMC Article | 12/5/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Analyses of shared genetic factors between asthma and obesity in children.
Melén E, Himes BE, Brehm JM, Boutaoui N, Klanderman BJ, Sylvia JS, Lasky-Su J., Free PMC Article | 12/5/2010 |
| germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein. | The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.
Liu Y, Bourgeois CF, Pang S, Kudla M, Dreumont N, Kister L, Sun YH, Stevenin J, Elliott DJ., Free PMC Article | 02/8/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.
Hancock DB, Romieu I, Shi M, Sienra-Monge JJ, Wu H, Chiu GY, Li H, del Rio-Navarro BE, Willis-Owen SA, Weiss ST, Raby BA, Gao H, Eng C, Chapela R, Burchard EG, Tang H, Sullivan PF, London SJ., Free PMC Article | 12/2/2009 |
| Knockdown of TLE1 or TLE4 levels increased the rate of cell division of the AML1-ETO-expressing Kasumi-1 cell line, whereas forced expression of either TLE1 or TLE4 caused apoptosis and cell death. | Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
Dayyani F, Wang J, Yeh JR, Ahn EY, Tobey E, Zhang DE, Bernstein ID, Peterson RT, Sweetser DA., Free PMC Article | 01/21/2010 |
| Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors | Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors.
Heimbucher T, Murko C, Bajoghli B, Aghaallaei N, Huber A, Stebegg R, Eberhard D, Fink M, Simeone A, Czerny T., Free PMC Article | 01/21/2010 |