| Cardiac muscle-restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features. | Cardiac muscle-restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features.
Smith A, Auer D, Johnson M, Sanchez E, Ross H, Ward C, Chakravarti A, Kapoor A., Free PMC Article | 11/14/2023 |
| Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice. | Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice.
Candemir E, Fattakhov N, Leary AO, Slattery DA, Courtney MJ, Reif A, Freudenberg F. | 02/4/2023 |
| Inducible over-expression of cardiac Nos1ap causes short QT syndrome in transgenic mice. | Inducible over-expression of cardiac Nos1ap causes short QT syndrome in transgenic mice.
Jänsch M, Lubomirov LT, Trum M, Williams T, Schmitt J, Schuh K, Qadri F, Maier LS, Bader M, Ritter O., Free PMC Article | 01/7/2023 |
| Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice. | Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.
Majmundar AJ, Buerger F, Forbes TA, Klämbt V, Schneider R, Deutsch K, Kitzler TM, Howden SE, Scurr M, Tan KS, Krzeminski M, Widmeier E, Braun DA, Lai E, Ullah I, Amar A, Kolb A, Eddy K, Chen CH, Salmanullah D, Dai R, Nakayama M, Ottlewski I, Kolvenbach CM, Onuchic-Whitford AC, Mao Y, Mann N, Nabhan MM, Rosen S, Forman-Kay JD, Soliman NA, Heilos A, Kain R, Aufricht C, Mane S, Lifton RP, Shril S, Little MH, Hildebrandt F., Free PMC Article | 04/30/2022 |
| Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders. | Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders.
Freudenberg F, Candemir E, Chen X, Li LL, Esen-Sehir D, Schenk N, Kinoshita M, Grünewald L, Frerichs V, Fattakhov N, Manchen J, Bikas S, Kumar A, OLeary A, Slattery DA, von Engelhardt J, Courtney MJ, Reif A., Free PMC Article | 02/5/2022 |
| CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model. | CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model.
Gao S, Zhang T, Jin L, Liang D, Fan G, Song Y, Lucassen PJ, Yu R, Swaab DF. | 10/10/2020 |
| nNOS-CAPON interaction may function via regulating structural neuroplasticity, rather than neuroprotection | Dissociating nNOS (Neuronal NO Synthase)-CAPON (Carboxy-Terminal Postsynaptic Density-95/Discs Large/Zona Occludens-1 Ligand of nNOS) Interaction Promotes Functional Recovery After Stroke via Enhanced Structural Neuroplasticity.
Ni HY, Song YX, Lin YH, Cao B, Wang DL, Zhang Y, Dong J, Liang HY, Xu K, Li TY, Chang L, Wu HY, Luo CX, Zhu DY. | 11/30/2019 |
| In models of Alzheimer's disease, increased nNOS-CAPON interaction was detected after treatment with amyloid-beta in vitro, and a similar change was found in the hippocampus of APP/PS1 mice (a transgenic mouse model of Alzheimer's disease), compared with age-matched background mice in vivo. | nNOS-CAPON interaction mediates amyloid-β-induced neurotoxicity, especially in the early stages.
Zhang Y, Zhu Z, Liang HY, Zhang L, Zhou QG, Ni HY, Luo CX, Zhu DY., Free PMC Article | 09/14/2019 |
| CAPON accumulated in the hippocampal pyramidal cell layer in the App(NL-G-F) -knock-in (KI) brain. In a model of Alzheimer's disease, CAPON overexpression produced significant hippocampal atrophy and caspase3-dependent neuronal cell death in the CAPON-expressing hippocampus, suggesting that CAPON accumulation increases neurodegeneration. | Tau binding protein CAPON induces tau aggregation and neurodegeneration.
Hashimoto S, Matsuba Y, Kamano N, Mihira N, Sahara N, Takano J, Muramatsu SI, Saido TC, Saito T., Free PMC Article | 06/29/2019 |
| results hint towards an involvement of NOS-I/NOS1AP interaction in the regulation of dendritic spine plasticity | Interaction of NOS1AP with the NOS-I PDZ domain: Implications for schizophrenia-related alterations in dendritic morphology.
Candemir E, Kollert L, Weißflog L, Geis M, Müller A, Post AM, O'Leary A, Harro J, Reif A, Freudenberg F. | 05/7/2017 |
| Genetic variations at Nos1ap were associated with Oxidative Stress Induced Ventricular Arrhythmia and Heart Failure, which may cause Sudden Cardiac Death. | Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice.
Sugiyama K, Sasano T, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M, Furukawa T. | 02/4/2017 |
| long-term expression of cocaine-induced behavioral sensitization in females (adolescent and adult) is nNOS-independent, unlike previous finding in adult males. | Development and persistence of long-lasting behavioral sensitization to cocaine in female mice: role of the nNOS gene.
Balda MA, Anderson KL, Itzhak Y. | 01/21/2010 |
| Capon expression is increased in skeletal muscle by position, repair, NOS activity, and dystrophy. | CAPON expression in skeletal muscle is regulated by position, repair, NOS activity, and dystrophy.
Ségalat L, Grisoni K, Archer J, Vargas C, Bertrand A, Anderson JE. | 01/21/2010 |