| Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes. | Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes.
Ahonen MA, Höring M, Nguyen VD, Qadri S, Taskinen JH, Nagaraj M, Wabitsch M, Fischer-Posovszky P, Zhou Y, Liebisch G, Haridas PAN, Yki-Järvinen H, Olkkonen VM., Free PMC Article | 06/25/2022 |
| THRSP identified as a potential hepatocellular carcinoma marker by integrated bioinformatics analysis and experimental validation. | THRSP identified as a potential hepatocellular carcinoma marker by integrated bioinformatics analysis and experimental validation.
Ding Y, Liu X, Yuan Y, Sheng Y, Li D, Ojha SC, Sun C, Deng C., Free PMC Article | 04/30/2022 |
| miR-451a might participate in the free fatty acid-induced hepatic steatosis by regulating the expression of the THRSP gene. | MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene.
Zeng N, Huang R, Li N, Jiang H, Li R, Wang F, Chen W, Xia M, Wang Q. | 05/11/2019 |
| The results of the present study indicated that Spot14/S14R were differently expressed in MSC adipogenesis in AIS patients, and they may be important in the abnormal adipogenic differentiation in AIS. | Spot14/Spot14R expression may be involved in MSC adipogenic differentiation in patients with adolescent idiopathic scoliosis.
Wang Q, Yang J, Lin X, Huang Z, Xie C, Fan H., Free PMC Article | 04/8/2017 |
| In human breast cancer cell lines, S14 expression was highest in those representing the luminal subtype compared to those cell lines with basal characteristics. | Modulation of tumor fatty acids, through overexpression or loss of thyroid hormone responsive protein spot 14 is associated with altered growth and metastasis.
Wellberg EA, Rudolph MC, Lewis AS, Padilla-Just N, Jedlicka P, Anderson SM., Free PMC Article | 11/14/2015 |
| N-terminally truncated human Thrsp and its selenomethionyl derivative were collected to 4.0, 3.0 and 3.6 A resolution | Expression, purification and preliminary crystallographic analysis of human thyroid hormone responsive protein.
Zhang W, Peng W, Zhao M, Lin D, Zeng Z, Zhou W, Bartlam M., Free PMC Article | 10/15/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| human Spot 14 protein might regulate the p53 target gene, p21(WAF1/Cip1), via its direct interaction with the thyroid receptor or other p53 coactivators, such as Zac1. | Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1.
Chou WY, Ho CL, Tseng ML, Liu ST, Yen LC, Huang SM. | 01/21/2010 |
| These findings provide a molecular rationale for the role of hS14 in TR-dependent transcriptional activation of the expression of specific genes. | Human spot 14 protein interacts physically and functionally with the thyroid receptor.
Chou WY, Cheng YS, Ho CL, Liu ST, Liu PY, Kuo CC, Chang HP, Chen YH, Chang GG, Huang SM. | 01/21/2010 |
| significantly greater thyroid hormone response for the human promoter, compared with the rat. | Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification.
Campbell MC, Anderson GW, Mariash CN. | 01/21/2010 |