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    BUB1B BUB1 mitotic checkpoint serine/threonine kinase B [ Homo sapiens (human) ]

    Gene ID: 701, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    BUB1b impairs chemotherapy sensitivity via resistance to ferroptosis in lung adenocarcinoma.

    BUB1b impairs chemotherapy sensitivity via resistance to ferroptosis in lung adenocarcinoma.
    Ding Y, Gao J, Chen J, Ren J, Jiang J, Zhang Z, Tong X, Zhao J., Free PMC Article

    08/23/2024
    Correlation of BUB1 and BUB1B with the development and prognosis of endometrial cancer.

    Correlation of BUB1 and BUB1B with the development and prognosis of endometrial cancer.
    Zhang H, Li Y, Lu H., Free PMC Article

    07/29/2024
    Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.

    Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.
    Zeng Q, Zhang S, He L, Fu Q, Liao L, Chen L, Ding X.

    04/17/2024
    BubR1 and cyclin B1 immunoexpression in pleomorphic adenoma and polymorphous adenocarcinoma of minor salivary glands.

    BubR1 and cyclin B1 immunoexpression in pleomorphic adenoma and polymorphous adenocarcinoma of minor salivary glands.
    Cavalcante IL, Silva Barros CCD, Colares DF, Cruz VMS, de Andrade BAB, Nonaka CFW, Rabenhorst SHB, Cavalcante RB.

    02/2/2024
    E3-ubiquitin ligase, FBXW7 regulates mitotic progression by targeting BubR1 for ubiquitin-mediated degradation.

    E3-ubiquitin ligase, FBXW7 regulates mitotic progression by targeting BubR1 for ubiquitin-mediated degradation.
    Nair VM, Sabu AS, Hussain A, Kombarakkaran DP, Lakshmi RB, Manna TK., Free PMC Article

    11/30/2023
    Clinical value and potential mechanisms of BUB1B up-regulation in nasopharyngeal carcinoma.

    Clinical value and potential mechanisms of BUB1B up-regulation in nasopharyngeal carcinoma.
    Qin LT, Huang SW, Huang ZG, Dang YW, Fang YY, He J, Niu YT, Lin CX, Wu JY, Wei ZX., Free PMC Article

    01/11/2023
    BubR1 recruitment to the kinetochore via Bub1 enhances spindle assembly checkpoint signaling.

    BubR1 recruitment to the kinetochore via Bub1 enhances spindle assembly checkpoint signaling.
    Banerjee A, Chen C, Humphrey L, Tyson JJ, Joglekar AP., Free PMC Article

    08/27/2022
    BUBs Are New Biomarkers of Promoting Tumorigenesis and Affecting Prognosis in Breast Cancer.

    BUBs Are New Biomarkers of Promoting Tumorigenesis and Affecting Prognosis in Breast Cancer.
    Wang S, Liu X, Yang M, Yuan D, Ye K, Qu X, Wang X., Free PMC Article

    05/14/2022
    BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability.

    BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability.
    Tang X, Guo M, Ding P, Deng Z, Ke M, Yuan Y, Zhou Y, Lin Z, Li M, Gu C, Gu X, Yang Y., Free PMC Article

    03/5/2022
    BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis.

    BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis.
    Zhou X, Yuan Y, Kuang H, Tang B, Zhang H, Zhang M., Free PMC Article

    02/26/2022
    Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents.

    Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents.
    Komura K, Inamoto T, Tsujino T, Matsui Y, Konuma T, Nishimura K, Uchimoto T, Tsutsumi T, Matsunaga T, Maenosono R, Yoshikawa Y, Taniguchi K, Tanaka T, Uehara H, Hirata K, Hirano H, Nomi H, Hirose Y, Ono F, Azuma H., Free PMC Article

    01/1/2022
    BUBR1 Pseudokinase Domain Promotes Kinetochore PP2A-B56 Recruitment, Spindle Checkpoint Silencing, and Chromosome Alignment.

    BUBR1 Pseudokinase Domain Promotes Kinetochore PP2A-B56 Recruitment, Spindle Checkpoint Silencing, and Chromosome Alignment.
    Gama Braga L, Cisneros AF, Mathieu MM, Clerc M, Garcia P, Lottin B, Garand C, Thebault P, Landry CR, Elowe S.

    11/13/2021
    Coupling of Cdc20 inhibition and activation by BubR1.

    Coupling of Cdc20 inhibition and activation by BubR1.
    Hein JB, Garvanska DH, Nasa I, Kettenbach AN, Nilsson J., Free PMC Article

    10/2/2021
    BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways.

    BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways.
    Jiao CY, Feng QC, Li CX, Wang D, Han S, Zhang YD, Jiang WJ, Chang J, Wang X, Li XC., Free PMC Article

    10/2/2021
    Rare deleterious BUB1B variants induce premature ovarian insufficiency and early menopause.

    Rare deleterious BUB1B variants induce premature ovarian insufficiency and early menopause.
    Chen Q, Ke H, Luo X, Wang L, Wu Y, Tang S, Li J, Jin L, Zhang F, Qin Y, Chen X.

    08/28/2021
    Twist1 induces chromosomal instability (CIN) in colorectal cancer cells.

    Twist1 induces chromosomal instability (CIN) in colorectal cancer cells.
    Khot M, Sreekumar D, Jahagirdar S, Kulkarni A, Hari K, Faseela EE, Sabarinathan R, Jolly MK, Sengupta K., Free PMC Article

    08/14/2021
    Expression and prognosis analyses of BUB1, BUB1B and BUB3 in human sarcoma.

    Expression and prognosis analyses of BUB1, BUB1B and BUB3 in human sarcoma.
    Long Z, Wu T, Tian Q, Carlson LA, Wang W, Wu G., Free PMC Article

    07/31/2021
    [Prognostic values of spindle checkpoint protein BUB1B in triple negative breast cancer].

    [Prognostic values of spindle checkpoint protein BUB1B in triple negative breast cancer].
    Zhang PC, Zhong XR, Zheng H, Li L, Chen F, Shen MJ, Li YJ, Chen H, Cao SY, Bu H, Ye F.

    06/12/2021
    Spindle assembly checkpoint gene BUB1B is essential in breast cancer cell survival.

    Spindle assembly checkpoint gene BUB1B is essential in breast cancer cell survival.
    Koyuncu D, Sharma U, Goka ET, Lippman ME.

    06/5/2021
    BUB1B Promotes Proliferation of Prostate Cancer via Transcriptional Regulation of MELK.

    BUB1B Promotes Proliferation of Prostate Cancer via Transcriptional Regulation of MELK.
    Tian JH, Mu LJ, Wang MY, Zeng J, Long QZ, Guan B, Wang W, Jiang YM, Bai XJ, Du YF.

    05/29/2021
    BUB1B promotes hepatocellular carcinoma progression via activation of the mTORC1 signaling pathway.

    BUB1B promotes hepatocellular carcinoma progression via activation of the mTORC1 signaling pathway.
    Qiu J, Zhang S, Wang P, Wang H, Sha B, Peng H, Ju Z, Rao J, Lu L., Free PMC Article

    05/8/2021
    BUB1B Overexpression Is an Independent Prognostic Marker and Associated with CD44, p53, and PD-L1 in Renal Cell Carcinoma.

    BUB1B Overexpression Is an Independent Prognostic Marker and Associated with CD44, p53, and PD-L1 in Renal Cell Carcinoma.
    Sekino Y, Han X, Kobayashi G, Babasaki T, Miyamoto S, Kobatake K, Kitano H, Ikeda K, Goto K, Inoue S, Hayashi T, Teishima J, Sakamoto N, Sentani K, Oue N, Yasui W, Matsubara A.

    04/17/2021
    Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death Against Human Non-Small Cell Lung Cancers.

    Discovery of Novel Agents on Spindle Assembly Checkpoint to Sensitize Vinorelbine-Induced Mitotic Cell Death Against Human Non-Small Cell Lung Cancers.
    Chang YC, Tseng YL, Leu WJ, Du CM, Jiang YH, Hsu LC, Hsu JL, Hou DR, Guh JH., Free PMC Article

    02/20/2021
    Downregulation of Mad2 and BubR1 increase the malignant behavior and nocodazole resistance of SiHa cells via causing spindle assembly checkpoint defect.

    Downregulation of Mad2 and BubR1 increase the malignant potential and nocodazole resistance by compromising spindle assembly checkpoint signaling pathway in cervical carcinogenesis.
    Wang L, Wang J, Jin Y, Zheng J, Yang Y, Xi X.

    06/6/2020
    the ependymal cell layer does not form in the conditional knockout, revealing an unrecognized role of BubR1 in assuring the integrity of the ventricular system, which may account for the presence of hydrocephalus in some patients.

    Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death.
    Simmons AJ, Park R, Sterling NA, Jang MH, van Deursen JMA, Yen TJ, Cho SH, Kim S., Free PMC Article

    02/8/2020
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