| Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine. | Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine.
Schnable BL, Schaich MA, Roginskaya V, Leary LP, Weaver TM, Freudenthal BD, Drohat AC, Van Houten B., Free PMC Article | 10/31/2024 |
| Comprehensive analysis of the prognostic value and biological function of TDG in hepatocellular carcinoma. | Comprehensive analysis of the prognostic value and biological function of TDG in hepatocellular carcinoma.
Wang G, Zhou Y, Yi B, Long Y, Ma B, Zhang Y., Free PMC Article | 06/23/2023 |
| TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis. | TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis.
Miao J, Zhao C, Tang K, Xiong X, Wu F, Xue W, Duan B, Zhang H, Jing X, Li W, Sun Y, Hou N, Huang C., Free PMC Article | 04/23/2022 |
| Direct and Base Excision Repair-Mediated Regulation of a GC-Rich cis-Element in Response to 5-Formylcytosine and 5-Carboxycytosine. | Direct and Base Excision Repair-Mediated Regulation of a GC-Rich cis-Element in Response to 5-Formylcytosine and 5-Carboxycytosine.
Müller N, Ponkkonen E, Carell T, Khobta A., Free PMC Article | 01/1/2022 |
| Reversible chromatin condensation by the DNA repair and demethylation factor thymine DNA glycosylase. | Reversible chromatin condensation by the DNA repair and demethylation factor thymine DNA glycosylase.
Deckard CE, Sczepanski JT., Free PMC Article | 03/27/2021 |
| lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis. | lncRNA H19 contributes to oxidative damage repair in the early age-related cataract by regulating miR-29a/TDG axis.
Cheng T, Xu M, Qin B, Wu J, Tu Y, Kang L, Wang Y, Guan H., Free PMC Article | 09/5/2020 |
| TDG is expressed in melanoma and plays a role in cell cycle and cell proliferation. | Thymine DNA glycosylase as a novel target for melanoma.
Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A., Free PMC Article | 10/26/2019 |
| Effect of sumoylation on the rate of base excision by TDG. | Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase.
Coey CT, Drohat AC., Free PMC Article | 08/24/2019 |
| Data show that after replacing the thymine DNA glycosylase (TDG) residue Gly142 with tyrosine, the thymine release is delayed compared to the wild-type (wt) TDG. | Dynamics of the excised base release in thymine DNA glycosylase during DNA repair process.
Da LT, Shi Y, Ning G, Yu J., Free PMC Article | 07/27/2019 |
| TDG rs4135050 is associated with cigarette smoking in Saudi population. | Effect of the thymine-DNA glycosylase rs4135050 variant on Saudi smoker population.
Almutairi M, Mohammad Alhadeq A, Almeer R, Almutairi M, Alzahrani M, Semlali A., Free PMC Article | 05/25/2019 |
| The authors confirm direct NEIL1 TDG binding and NEIL1 mediated 2'-deoxyribose excision downstream of TDG glycosylase activity. NEIL1 acts not only downstream of TDG, but also enhances TDG activity on 5-formylcytosine or 5-carboxylcytosine containing DNA. | Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision.
Slyvka A, Mierzejewska K, Bochtler M., Free PMC Article | 04/6/2019 |
| TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells. | TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells.
Garcia-Gomez A, Li T, Kerick M, Català-Moll F, Comet NR, Rodríguez-Ubreva J, de la Rica L, Branco MR, Martín J, Ballestar E., Free PMC Article | 10/21/2017 |
| Results indicate how Thymine DNA glycosylase (TDG) employs an adaptable active site to excise a broad variety of nucleobases from DNA. | Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase.
Pidugu LS, Flowers JW, Coey CT, Pozharski E, Greenberg MM, Drohat AC., Free PMC Article | 05/27/2017 |
| Results indicate the presence of base excision repair -dependent and base excision repair-independent functions of TDG, which are involved in regulation of cellular DNA damage responses and gene expression patterns. | Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms.
Nakamura T, Murakami K, Tada H, Uehara Y, Nogami J, Maehara K, Ohkawa Y, Saitoh H, Nishitani H, Ono T, Nishi R, Yokoi M, Sakai W, Sugasawa K. | 04/22/2017 |
| findings indicate that sumoylation and SUMO binding are not essential for TDG-mediated excision and repair of 5-carboxylcytosine bases. | Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo.
McLaughlin D, Coey CT, Yang WC, Drohat AC, Matunis MJ., Free PMC Article | 11/5/2016 |
| Data show that Ras protein regulates inhibitor of growth protein 4 (ING4)-thymine-DNA glycosylase (TDG)-Fas protein axis to promote apoptosis resistance in pancreatic cancer. | Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance.
Sun J, Shen Q, Lu H, Jiang Z, Xu W, Feng L, Li L, Wang X, Cai X, Jin H., Free PMC Article | 10/1/2016 |
| A long TA repeat in the promoter region of IL28B was associated with spontaneous HCV clearance. | A thymine-adenine dinucleotide repeat polymorphism near IL28B is associated with spontaneous clearance of hepatitis C virus.
Hiramine S, Sugiyama M, Furusyo N, Uto H, Ido A, Tsubouchi H, Watanabe H, Ueno Y, Korenaga M, Murata K, Masaki N, Hayashi J, Thomas DL, Mizokami M., Free PMC Article | 08/13/2016 |
| NEIL1 and NEIL2 cooperate with TDG during base excision: TDG occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG-substrate turnover. | Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.
Schomacher L, Han D, Musheev MU, Arab K, Kienhöfer S, von Seggern A, Niehrs C., Free PMC Article | 07/2/2016 |
| Computational modeling study investigated the glycosidic bond cleavage reaction in human thymine DNA glycosylase | Mechanism of the Glycosidic Bond Cleavage of Mismatched Thymine in Human Thymine DNA Glycosylase Revealed by Classical Molecular Dynamics and Quantum Mechanical/Molecular Mechanical Calculations.
Kanaan N, Crehuet R, Imhof P. | 06/28/2016 |
| levels of TET3 and TDG mRNAs were independent prognostic factors for early breast cancer patients who received anthracycline chemotherapy | Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer.
Yang L, Yu SJ, Hong Q, Yang Y, Shao ZM., Free PMC Article | 05/14/2016 |
| TDG releases the excised base from its tight product complex with abasic DNA, contrary to previous reports. Moreover, DNA-free TDG exhibits no significant binding to free nucleobases (uracil, thymine, 5-hydroxymethyluracil) | Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
Malik SS, Coey CT, Varney KM, Pozharski E, Drohat AC., Free PMC Article | 03/5/2016 |
| these results suggest that individuals harboring the G199S in Thymine DNA glycosylase variant may have increased risk for developing cancer. | A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation.
Sjolund A, Nemec AA, Paquet N, Prakash A, Sung P, Doublié S, Sweasy JB., Free PMC Article | 11/14/2015 |
| Data indicate that both thymine-DNA glycosylase (hTDG) and a second glycosylase, hOGG1, recognized structurally different 8-oxoguanine lesions. | Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging.
Buechner CN, Maiti A, Drohat AC, Tessmer I., Free PMC Article | 06/27/2015 |
| TDG, as a new coactivator, promotes beta-catenin/TCFs transactivation and functionally cooperates with CBP in canonical Wnt signaling. | Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP.
Jia Y, Nie F, Du A, Chen Z, Qin Y, Huang T, Song X, Li L. | 04/11/2015 |
| CRL4(Cdt2)-dependent degradation of TDG occurs in S phase because of the requirement for TDG to interact with chromatin-loaded PCNA, and this degradation is important for preventing toxicity from excess TDG. | CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.
Shibata E, Dar A, Dutta A., Free PMC Article | 12/20/2014 |