| The spike-specific TCRbeta repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection. | The spike-specific TCRβ repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection.
Vecchio E, Rotundo S, Veneziano C, Abatino A, Aversa I, Gallo R, Giordano C, Serapide F, Fusco P, Viglietto G, Cuda G, Costanzo F, Russo A, Trecarichi EM, Torti C, Palmieri C., Free PMC Article | 01/12/2024 |
| Characterization of the TCRbeta repertoire of peripheral MR1-restricted MAIT cells in psoriasis vulgaris patients. | Characterization of the TCRβ repertoire of peripheral MR1-restricted MAIT cells in psoriasis vulgaris patients.
Jirouš Drulak M, Grgić Z, Plužarić V, Šola M, Opačak-Bernardi T, Viljetić B, Glavaš K, Tolušić-Levak M, Periša V, Mihalj M, Štefanić M, Tokić S., Free PMC Article | 12/1/2023 |
| Response to Hypomethylating Agents in Myelodysplastic Syndrome Is Associated With Emergence of Novel TCR Clonotypes. | Response to Hypomethylating Agents in Myelodysplastic Syndrome Is Associated With Emergence of Novel TCR Clonotypes.
Abbas HA, Reville PK, Jiang X, Yang H, Reuben A, Im JS, Little L, Sinson JC, Chen K, Futreal A, Garcia-Manero G., Free PMC Article | 10/23/2021 |
| T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4. | T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.
Coles CH, McMurran C, Lloyd A, Hock M, Hibbert L, Raman MCC, Hayes C, Lupardus P, Cole DK, Harper S., Free PMC Article | 01/23/2021 |
| Geometrical characterization of T cell receptor binding modes reveals class-specific binding to maximize access to antigen. | Geometrical characterization of T cell receptor binding modes reveals class-specific binding to maximize access to antigen.
Singh NK, Abualrous ET, Ayres CM, Noé F, Gowthaman R, Pierce BG, Baker BM., Free PMC Article | 01/9/2021 |
| The 3A6-TCR/superagonist/HLA-DR2a complex shows similar interface and reduced flexibility compared to the complex with self-peptide. | The 3A6-TCR/superagonist/HLA-DR2a complex shows similar interface and reduced flexibility compared to the complex with self-peptide.
Salutari I, Martin R, Caflisch A. | 11/21/2020 |
| T cell receptor alpha beta+/CD19+ graft depletion effectively prevents graft-versus-host disease. | Mismatched related vs matched unrelated donors in TCRαβ/CD19-depleted HSCT for primary immunodeficiencies.
Laberko A, Sultanova E, Gutovskaya E, Shipitsina I, Shelikhova L, Kurnikova E, Muzalevskii Y, Kazachenok A, Pershin D, Voronin K, Shcherbina A, Maschan M, Maschan A, Balashov D., Free PMC Article | 03/7/2020 |
| In this study, we applied high-throughput sequencing of the CDR3 region of TCRbeta to comprehensively interrogate diffuse large B-cell lymphoma nodal tissues. Data were collated with gene expression and survival to clarify the relationship between the clonal complexity of intra-tumoral T cells the TME and outcome after conventional frontline R-CHOP therapy | The T-cell Receptor Repertoire Influences the Tumor Microenvironment and Is Associated with Survival in Aggressive B-cell Lymphoma.
Keane C, Gould C, Jones K, Hamm D, Talaulikar D, Ellis J, Vari F, Birch S, Han E, Wood P, Le-Cao KA, Green MR, Crooks P, Jain S, Tobin J, Steptoe RJ, Gandhi MK. | 02/10/2018 |
| A conserved alpha-beta transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane. | A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane.
Krshnan L, Park S, Im W, Call MJ, Call ME., Free PMC Article | 02/3/2018 |
| Compared to healthy neonates, neonates with sepsis had different VJ pairs and generated different clonotypes. Although the TCR beta-chain diversity was generally lower in neonates with sepsis, there was no significant difference in TCR beta-chain diversity between patients and healthy controls. | Composition and Variation Analysis of the T Cell Receptor β-Chain Complementarity Determining Region 3 Repertoire in Neonatal Sepsis.
Sun J, Sun B, Gao Y, He F, Yang L, Wang M, Zhou W. | 10/28/2017 |
| Data suggest that T-cell receptor (TCR) alpha-constant domain (C- and F-strands) directly interacts with unbound MHC light chain, beta2-microglobulin (beta2M); these interactions do not appear to be involved in T-cell cytotoxicity, suggesting an alternate role for beta2M binding to TCR; TCR beta-chain does not appear to interact directly with beta2M. | The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β(2)-Microglobulin through Distinct Binding Sites.
Merkle PS, Irving M, Hongjian S, Ferber M, Jørgensen TJD, Scholten K, Luescher I, Coukos G, Zoete V, Cuendet MA, Michielin O, Rand KD. | 08/12/2017 |
| the molecular profiles of frequent T-cell receptor beta-chain variable patterns of regulatory T-cells were analyzed. | The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4(+)CD25(+) regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment.
Yang J, Sheng G, Xiao D, Shi H, Wu W, Lu H, Cao H, Li L., Free PMC Article | 07/22/2017 |
| Each newborn had a distinctive TRB-/IGH-CDR3 repertoire that was independent of the maternal immune status. | High-Throughput Sequencing Reveals Immunological Characteristics of the TRB-/IgH-CDR3 Region of Umbilical Cord Blood.
Guo C, Wang Q, Cao X, Yang Y, Liu X, An L, Cai R, Du M, Wang G, Qiu Y, Peng Z, Han J, Ni S, Tan X, Jin L, Yu S, Wang H, Wang C, Wang X, Ma X. | 06/24/2017 |
| Data indicate that public TCR complementarity-determining regions (CDR3) sequences and high-frequency sequences had the same characteristics, both of them had fewer nucleotide additions and shorter CDR3 length, which were closer to the germline sequence. | Analysis of the Repertoire Features of TCR Beta Chain CDR3 in Human by High-Throughput Sequencing.
Hou X, Wang M, Lu C, Xie Q, Cui G, Chen J, Du Y, Dai Y, Diao H. | 02/18/2017 |
| Data indicate the expression of a chimeric T-cell receptor alpha beta (alphabeta TCR) harboring the immunoglobulin-like (Ig) domain of T-cell receptor gamma delta (gammadelta TCR) in Jurkat T cells. | [Homology modeling and eukaryotic expression of a modified αβ TCR harboring the immunoglobulin-like domain of γδ TCR].
Tao C, Shao H, Shen H, Huang S. | 01/14/2017 |
| analysis of BV19 CD8 T cell repertoires on circulating CD8 T cells. | CDR3 motif generation and selection in the BV19-utilizing subset of the human CD8 T cell repertoire.
Yassai MB, Demos W, Gorski J., Free PMC Article | 08/27/2016 |
| Clonal TCR rearrangements in human anaplastic large cell lymphoma are predominantly in-frame, but often aberrant, with clonal TCRalpha but no comparable clonal TCRbeta rearrangement. | Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress.
Malcolm TI, Villarese P, Fairbairn CJ, Lamant L, Trinquand A, Hook CE, Burke GA, Brugières L, Hughes K, Payet D, Merkel O, Schiefer AI, Ashankyty I, Mian S, Wasik M, Turner M, Kenner L, Asnafi V, Macintyre E, Turner SD., Free PMC Article | 05/21/2016 |
| In conclusion, the single T cell receptor beta locus 2 expression check, instead of the entire repertoire assessment, represents an easy and cost-effective method for the recognition of cutaneous t cell lymphoma aggressive leukemic variant. | Single TCR-Vβ2 evaluation discloses the circulating T cell clone in Sezary syndrome: one family fits all!
Scala E, Abeni D, Pomponi D, Russo N, Russo G, Narducci MG. | 04/30/2016 |
| Folding of the TCR alpha-chain constant domain Calpha is dependent on alpha-beta heterodimerization. | Dimerization-dependent folding underlies assembly control of the clonotypic αβT cell receptor chains.
Feige MJ, Behnke J, Mittag T, Hendershot LM., Free PMC Article | 02/6/2016 |
| the expression levels of 10 TRbetaV segments and 6 TRbetaJ segments were also significantly different in the systemic lupus erythematosus group. | Composition and variation analysis of the TCR β-chain CDR3 repertoire in systemic lupus erythematosus using high-throughput sequencing.
Sui W, Hou X, Zou G, Che W, Yang M, Zheng C, Liu F, Chen P, Wei X, Lai L, Dai Y. | 12/19/2015 |
| The docking site for CD3 subunits on the T Cell receptor beta chain has been identified by solution NMR. | Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.
He Y, Rangarajan S, Kerzic M, Luo M, Chen Y, Wang Q, Yin Y, Workman CJ, Vignali KM, Vignali DA, Mariuzza RA, Orban J., Free PMC Article | 11/7/2015 |
| Data indicate that most patients receiving T cell receptor alpha/beta alphabeta-depleted stem cell boosts increased their levels of white blood cells, platelets, and/or granulocytes 30 days after infusion. | Alpha/beta T-cell depleted grafts as an immunological booster to treat graft failure after hematopoietic stem cell transplantation with HLA-matched related and unrelated donors.
Rådestad E, Wikell H, Engström M, Watz E, Sundberg B, Thunberg S, Uzunel M, Mattsson J, Uhlin M., Free PMC Article | 06/27/2015 |
| analysis of the molecular organization of the TCR-CD3 complex | Molecular architecture of the αβ T cell receptor-CD3 complex.
Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC., Free PMC Article | 05/2/2015 |
| macrophage-TCRalphabeta combinatorial immunoreceptor has roles in atherosclerosis | The macrophage-TCRαβ is a cholesterol-responsive combinatorial immune receptor and implicated in atherosclerosis.
Fuchs T, Puellmann K, Emmert A, Fleig J, Oniga S, Laird R, Heida NM, Schäfer K, Neumaier M, Beham AW, Kaminski WE. | 03/21/2015 |
| Data suggest a stratification of Tcrb recombination signal sequences (RSSs) into two categories: RSSs that nick slowly in the signal complex and RSSs that nick quickly in the signal complex. | Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” rule.
Banerjee JK, Schatz DG., Free PMC Article | 12/20/2014 |