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    TRA T cell receptor alpha locus [ Homo sapiens (human) ]

    Gene ID: 6955, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Type B thymomas in patients with myasthenia gravis display a distinctive pattern of alphabeta TCR and IL-7 receptor alpha expression on CD4[+]CD8[+] thymocytes.

    Type B thymomas in patients with myasthenia gravis display a distinctive pattern of αβ TCR and IL-7 receptor α expression on CD4(+)CD8(+) thymocytes.
    Wang T, Wang B, Fan X, Cai Y, Li L, Fu S.

    06/5/2024
    Selective ablation of TRA-1-60[+] pluripotent stem cells suppresses tumor growth of prostate cancer.

    Selective ablation of TRA-1-60(+) pluripotent stem cells suppresses tumor growth of prostate cancer.
    White JM, Ramos N, Saliganan AD, Chung JY, Bell M, Lindquist J, Conner K, Wiesend WN, Schopperle M, Patrick SM, Kim S, Heath EI, Escorcia FE, Viola NT., Free PMC Article

    05/12/2023
    T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.

    T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.
    Tewari R, Shayahati B, Fan Y, Akimzhanov AM., Free PMC Article

    08/28/2021
    Electrostatic Complementarity of T-Cell Receptor-Alpha CDR3 Domains and Mutant Amino Acids Is Associated with Better Survival Rates for Sarcomas.

    Electrostatic Complementarity of T-Cell Receptor-Alpha CDR3 Domains and Mutant Amino Acids Is Associated with Better Survival Rates for Sarcomas.
    Yeagley M, Chobrutskiy BI, Gozlan EC, Medikonda N, Patel DN, Falasiri S, Callahan BM, Huda T, Blanck G.

    06/12/2021
    T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.

    T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.
    Coles CH, McMurran C, Lloyd A, Hock M, Hibbert L, Raman MCC, Hayes C, Lupardus P, Cole DK, Harper S., Free PMC Article

    01/23/2021
    Geometrical characterization of T cell receptor binding modes reveals class-specific binding to maximize access to antigen.

    Geometrical characterization of T cell receptor binding modes reveals class-specific binding to maximize access to antigen.
    Singh NK, Abualrous ET, Ayres CM, Noé F, Gowthaman R, Pierce BG, Baker BM., Free PMC Article

    01/9/2021
    The 3A6-TCR/superagonist/HLA-DR2a complex shows similar interface and reduced flexibility compared to the complex with self-peptide.

    The 3A6-TCR/superagonist/HLA-DR2a complex shows similar interface and reduced flexibility compared to the complex with self-peptide.
    Salutari I, Martin R, Caflisch A.

    11/21/2020
    T cell receptor alpha beta+/CD19+ graft depletion effectively prevents graft-versus-host disease.

    Mismatched related vs matched unrelated donors in TCRαβ/CD19-depleted HSCT for primary immunodeficiencies.
    Laberko A, Sultanova E, Gutovskaya E, Shipitsina I, Shelikhova L, Kurnikova E, Muzalevskii Y, Kazachenok A, Pershin D, Voronin K, Shcherbina A, Maschan M, Maschan A, Balashov D., Free PMC Article

    03/7/2020
    A conserved alpha-beta transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane.

    A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane.
    Krshnan L, Park S, Im W, Call MJ, Call ME., Free PMC Article

    02/3/2018
    Data (from studies using TCR-F50/GIL/HLA-A2) suggest there are multiple structurally distinct solutions to recognizing identical peptide-MHC ligand with sufficient affinity to elicit broad anti- influenza A virus response protective against viral escape/T-cell clonal loss. (TCR-F50 = GIL-specific T-cell receptor, alpha-beta; HLA-A2 major histocompatibility complex class I A; GIL = immunodominant influenza A virus epitope)

    Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope.
    Yang X, Chen G, Weng NP, Mariuzza RA., Free PMC Article

    12/23/2017
    upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 via phosphorylation of S339-CXCR4 in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2), IL-4, and IL-10 messenger RNA (mRNA) transcripts.

    TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL.
    Kremer KN, Dinkel BA, Sterner RM, Osborne DG, Jevremovic D, Hedin KE., Free PMC Article

    09/30/2017
    Data suggest that T-cell receptor (TCR) alpha-constant domain (C- and F-strands) directly interacts with unbound MHC light chain, beta2-microglobulin (beta2M); these interactions do not appear to be involved in T-cell cytotoxicity, suggesting an alternate role for beta2M binding to TCR; TCR beta-chain does not appear to interact directly with beta2M.

    The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β(2)-Microglobulin through Distinct Binding Sites.
    Merkle PS, Irving M, Hongjian S, Ferber M, Jørgensen TJD, Scholten K, Luescher I, Coukos G, Zoete V, Cuendet MA, Michielin O, Rand KD.

    08/12/2017
    Data indicate the expression of a chimeric T-cell receptor alpha beta (alphabeta TCR) harboring the immunoglobulin-like (Ig) domain of T-cell receptor gamma delta (gammadelta TCR) in Jurkat T cells.

    [Homology modeling and eukaryotic expression of a modified αβ TCR harboring the immunoglobulin-like domain of γδ TCR].
    Tao C, Shao H, Shen H, Huang S.

    01/14/2017
    Studies indicate that T-cell receptors Tcra and Tcrd transit from an unrearranged configuration to a rearranged configuration during T-cell development.

    Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.
    Hernández-Munain C., Free PMC Article

    09/10/2016
    These results are formal proof that PD-1 induction through TCR activation on T cells is partially regulated by endogenous TGF-beta.

    PD-1 induction through TCR activation is partially regulated by endogenous TGF-β.
    Rekik R, Belhadj Hmida N, Ben Hmid A, Zamali I, Kammoun N, Ben Ahmed M., Free PMC Article

    06/11/2016
    Clonal TCR rearrangements in human anaplastic large cell lymphoma are predominantly in-frame, but often aberrant, with clonal TCRalpha but no comparable clonal TCRbeta rearrangement.

    Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress.
    Malcolm TI, Villarese P, Fairbairn CJ, Lamant L, Trinquand A, Hook CE, Burke GA, Brugières L, Hughes K, Payet D, Merkel O, Schiefer AI, Ashankyty I, Mian S, Wasik M, Turner M, Kenner L, Asnafi V, Macintyre E, Turner SD., Free PMC Article

    05/21/2016
    TCRA analysis improve monitoring and recurrence of the neoplasms in patients diagnosed with mycosis fungoides.

    T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides.
    Sufficool KE, Lockwood CM, Abel HJ, Hagemann IS, Schumacher JA, Kelley TW, Duncavage EJ.

    10/10/2015
    Gads was dispensable for TCR-induced phosphorylation of SLP-76, but was a dose-dependent amplifier of TCR-induced CD69 expression.

    Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.
    Lugassy J, Corso J, Beach D, Petrik T, Oellerich T, Urlaub H, Yablonski D.

    08/15/2015
    Data indicate that most patients receiving T cell receptor alpha/beta alphabeta-depleted stem cell boosts increased their levels of white blood cells, platelets, and/or granulocytes 30 days after infusion.

    Alpha/beta T-cell depleted grafts as an immunological booster to treat graft failure after hematopoietic stem cell transplantation with HLA-matched related and unrelated donors.
    Rådestad E, Wikell H, Engström M, Watz E, Sundberg B, Thunberg S, Uzunel M, Mattsson J, Uhlin M., Free PMC Article

    06/27/2015
    analysis of the molecular organization of the TCR-CD3 complex

    Molecular architecture of the αβ T cell receptor-CD3 complex.
    Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC., Free PMC Article

    05/2/2015
    Primary T cells produce extracellular superoxide upon TCR triggering, potentially via NOX2 at the plasma membrane. However, superoxide is not required for T-cell activation, proliferation and cytokine production.

    TCR-triggered extracellular superoxide production is not required for T-cell activation.
    Belikov AV, Schraven B, Simeoni L., Free PMC Article

    04/11/2015
    These findings highlight how components from alphabeta and gammadeltaTCR gene loci can recombine to confer antigenic specificity.

    The molecular bases of δ/αβ T cell-mediated antigen recognition.
    Pellicci DG, Uldrich AP, Le Nours J, Ross F, Chabrol E, Eckle SB, de Boer R, Lim RT, McPherson K, Besra G, Howell AR, Moretta L, McCluskey J, Heemskerk MH, Gras S, Rossjohn J, Godfrey DI., Free PMC Article

    03/21/2015
    macrophage-TCRalphabeta combinatorial immunoreceptor has roles in atherosclerosis

    The macrophage-TCRαβ is a cholesterol-responsive combinatorial immune receptor and implicated in atherosclerosis.
    Fuchs T, Puellmann K, Emmert A, Fleig J, Oniga S, Laird R, Heida NM, Schäfer K, Neumaier M, Beham AW, Kaminski WE.

    03/21/2015
    Mucosal-associated invariant T cell adaptation was a direct consequence of exposure to various exogenous MR1-restricted epitopes.

    MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage.
    Gold MC, McLaren JE, Reistetter JA, Smyk-Pearson S, Ladell K, Swarbrick GM, Yu YY, Hansen TH, Lund O, Nielsen M, Gerritsen B, Kesmir C, Miles JJ, Lewinsohn DA, Price DA, Lewinsohn DM., Free PMC Article

    09/27/2014
    TL1A, together with IL-12, IL-15 and IL-18, directly induces the production of IL-6 and TNF-alpha from PLZF leukocytes.

    TL1A induces TCR independent IL-6 and TNF-α production and growth of PLZF⁺ leukocytes.
    Reichwald K, Jørgensen TZ, Tougaard P, Skov S., Free PMC Article

    09/13/2014
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