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    MIR552 microRNA 552 [ Homo sapiens (human) ]

    Gene ID: 693137, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Regulation of the PD-1/PD-L1 Axis and NK Cell Dysfunction by Exosomal miR-552-5p in Gastric Cancer.

    Regulation of the PD-1/PD-L1 Axis and NK Cell Dysfunction by Exosomal miR-552-5p in Gastric Cancer.
    Tang CW, Yang JH, Qin JW, Wu HJ, Cui HP, Ge LY, Liu AQ., Free PMC Article

    09/29/2024
    miR-552 promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma by targeting FOXO1.

    miR-552 promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma by targeting FOXO1.
    Cheng Z, Cheng N, Tang X, Yang F, Ma W, Yu Q, Tang H, Xiao Q, Lei Z.

    09/11/2023
    MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes.

    MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes.
    Ma N, Hou A, Pan X, Sun F, Xu X, Yu C, Lai R, Huang R, Gong L, Xie Q, Chen J, Ren J., Free PMC Article

    09/8/2023
    ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma.

    ZNF8-miR-552-5p Axis Modulates ACSL4-Mediated Ferroptosis in Hepatocellular Carcinoma.
    Yang H, Sun W, Bi T, Sun J, Lu Z, Li J, Wei H.

    06/7/2023
    m[6]A-mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR-552-5p.

    m(6)A‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p.
    Liu W, Zhang Z, Luo X, Qian K, Huang B, Liang J, Ma Z, Deng J, Yang C., Free PMC Article

    06/7/2023
    MiR-552-3p facilitated cell proliferation, migration and invasion by sponging Fibulin 5 in non-small cell lung cancer via activation of ERK/GSK3beta/beta-catenin signaling pathway.

    MiR-552-3p facilitated cell proliferation, migration and invasion by sponging Fibulin 5 in non-small cell lung cancer via activation of ERK/GSK3β/β-catenin signaling pathway.
    Huang M, Liao X, Li L, Li G, Chen M.

    03/5/2022
    Circular RNA SMARCA5 functions as an anti-tumor candidate in colon cancer by sponging microRNA-552.

    Circular RNA SMARCA5 functions as an anti-tumor candidate in colon cancer by sponging microRNA-552.
    Yang S, Gao S, Liu T, Liu J, Zheng X, Li Z., Free PMC Article

    01/29/2022
    FOXM1-induced miR-552 expression contributes to pancreatic cancer progression by targeting multiple tumor suppressor genes.

    FOXM1-induced miR-552 expression contributes to pancreatic cancer progression by targeting multiple tumor suppressor genes.
    Wang X, Dou N, Wang J, Zhang Y, Li Y, Gao Y., Free PMC Article

    01/22/2022
    miR-552 promotes laryngocarcinoma cells proliferation and metastasis by targeting p53 pathway.

    miR-552 promotes laryngocarcinoma cells proliferation and metastasis by targeting p53 pathway.
    Gu J, Han T, Sun L, Yan AH, Jiang XJ., Free PMC Article

    07/31/2021
    Linc00261 inhibits metastasis and the WNT signaling pathway of pancreatic cancer by regulating a miR5525p/FOXO3 axis.

    Linc00261 inhibits metastasis and the WNT signaling pathway of pancreatic cancer by regulating a miR‑552‑5p/FOXO3 axis.
    Chen T, Lei S, Zeng Z, Zhang J, Xue Y, Sun Y, Lan J, Xu S, Mao D, Guo B., Free PMC Article

    09/26/2020
    High miR-552 expression is associated with Proliferation, Migration, and Invasion of Gastric Cancer.

    Upregulation of miR-552 Predicts Unfavorable Prognosis of Gastric Cancer and Promotes the Proliferation, Migration, and Invasion of Gastric Cancer Cells.
    Feng X, Zhu M, Liao B, Tian T, Li M, Wang Z, Chen G.

    07/11/2020
    We demonstrated for the first time that miR-552 expression is upregulated in ovarian cancer tissues, and miR-552 shRNA silencing suppresses the growth and metastasis of ovarian cancer cells. Moreover, miR-552 promoted ovarian cancer cell progression by PTEN signaling pathway.

    miR-552 promotes ovarian cancer progression by regulating PTEN pathway.
    Zhao W, Han T, Li B, Ma Q, Yang P, Li H., Free PMC Article

    05/30/2020
    The findings suggested that miR-552 promotes hepatocellular carcinoma oncogenesis and progression by inhibiting AJAP1 expression.

    MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression.
    Qu W, Wen X, Su K, Gou W., Free PMC Article

    05/23/2020
    TIMP2 is a direct downstream target of miR-552 in osteosarcoma.

    MicroRNA-552 promotes migration and invasion of osteosarcoma through targeting TIMP2.
    Chao Y, Hu K, Wang X, Wang L.

    12/14/2019
    MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1

    MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1.
    Li C, Wang Z, Chen S, Zhang J, Qu K, Liu C., Free PMC Article

    02/23/2019
    Study revealed that the Wnt/beta-catenin signaling pathway and its major downstream target, c-Myc increased the miR552 levels and miR552 directly targets p53 tumor suppressor. miR552 may serve as an important link between functional loss of APC, leading to abnormal Wnt signals, and the absence of p53 protein in colorectal cancer.

    MicroRNA-552 links Wnt signaling to p53 tumor suppressor in colorectal cancer.
    Kwak B, Kim DU, Kim TO, Kim HS, Kim SW.

    12/22/2018
    miR-552 is an oncomir able to promote colorectal cancer metastasis in part through a mechanism of targeting ADAM28.

    MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28.
    Wang J, Li H, Wang Y, Wang L, Yan X, Zhang D, Ma X, Du Y, Liu X, Yang Y., Free PMC Article

    02/24/2018
    MiR-552 with mutations in non-seed region losses its transcriptional, but retains its post-transcriptional repression to CYP2E1. In contrast, mutation in miR-552 seed sequence suppresses its inhibitory effects on CYP2E1 expression at protein

    A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1.
    Miao L, Yao H, Li C, Pu M, Yao X, Yang H, Qi X, Ren J, Wang Y.

    06/28/2016
    Study showd three microRNAs miR-5000-3p, miR-5009-3P and miR-552 were found to be upregulated in side population cells of colon cancer cell lines .

    MiR-5000-3p, miR-5009-3P and miR-552: potential microRNA biomarkers of side population cells in colon cancer.
    Xia ZS, Wang L, Yu T, Zhong W, Lian GD, Wu D, Zhou HM, Chen GC.

    02/14/2015
    miR-552 and miR-592 were overexpressed in primary colorectal cancer relative to primary lung adenocarcinomas

    miR-592 and miR-552 can distinguish between primary lung adenocarcinoma and colorectal cancer metastases in the lung.
    Kim HK, Lim NJ, Jang SG, Lee GK.

    06/28/2014
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