| Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect of psychosocial stress to elevate serum cholesterol. | Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect of psychosocial stress to elevate serum cholesterol.
Guo QW, Lin J, Shen YL, Zheng YJ, Chen X, Su M, Zhang JC, Wang JH, Tang H, Su GM, Li ZK, Fang DZ. | 10/29/2024 |
| Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. | Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.
Zhang J, Ruiz M, Bergh PO, Henricsson M, Stojanović N, Devkota R, Henn M, Bohlooly-Y M, Hernández-Hernández A, Alsheimer M, Borén J, Pilon M, Shibuya H., Free PMC Article | 03/19/2024 |
| The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation. | The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation.
Murayama MA, Chi HH, Matsuoka M, Ono T, Iwakura Y., Free PMC Article | 02/12/2022 |
| ADIPOR activation restores AMPK (AMP-activated protein kinase)-mediated autophagosome formation and antioxidant-mediated autophagosome clearance, representing a novel intervention effective against myocardial ischemia-reperfusion injury in diabetic conditions. | Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling.
Wang Y, Liang B, Lau WB, Du Y, Guo R, Yan Z, Gan L, Yan W, Zhao J, Gao E, Koch W, Ma XL., Free PMC Article | 06/8/2019 |
| these results demonstrate that AdipoR1 and AdipoR2 exhibit overlapping and distinct effects in skeletal muscle consistent with enhanced adiponectin sensitivity but these appear insufficient to ameliorate established obesity-induced adiponectin resistance. | Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects.
Keshvari S, Henstridge DC, Ng C, Febbraio MA, Whitehead JP., Free PMC Article | 10/27/2018 |
| macrophage polarization is a key determinant regulating AdipoR expression and differential APN-mediated macrophage inflammatory responses | Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response.
van Stijn CM, Kim J, Lusis AJ, Barish GD, Tangirala RK., Free PMC Article | 04/4/2015 |
| AdipoR1, but not AdipoR2 deficiency, leads to diet-induced metabolic dysfunction, revealing that these receptors have highly divergent roles in vascular and metabolic homeostasis | Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo.
Parker-Duffen JL, Nakamura K, Silver M, Zuriaga MA, MacLauchlan S, Aprahamian TR, Walsh K., Free PMC Article | 10/11/2014 |
| Data suggest GnRH (gonadotropin-releasing hormone) neurons in forebrain express AdipoR2 (not AdipoR1); adiponectin/AdipoR2 signal transduction via protein kinase C zeta down-regulates neurotransmission in subpopulation of GnRH neurons. | Metabolic influences on reproduction: adiponectin attenuates GnRH neuronal activity in female mice.
Klenke U, Taylor-Burds C, Wray S., Free PMC Article | 06/21/2014 |
| These results prove that elevation of adiponectin and/or adipoR2 expression via gene transfer is an effective approach in managing obesity epidemics. | Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-induced obesity and insulin resistance.
Ma Y, Liu D., Free PMC Article | 11/2/2013 |
| APN, AdipoR1, and AdipoR2 exist in human and mouse retinas and retinal APN and AdipoR1 protein levels are elevated in type 1 diabetes mellitus mice. | Expression of adiponectin and its receptors in type 1 diabetes mellitus in human and mouse retinas.
Lin T, Qiu Y, Liu Y, Mohan R, Li Q, Lei B., Free PMC Article | 09/28/2013 |
| Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue. | Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice.
Farias JM, Maggi RM, Tromm CB, Silva LA, Luciano TF, Marques SO, Lira FS, de Souza CT, Pinho RA., Free PMC Article | 06/22/2013 |
| Human biosynthetic insulin had little or no effect in the regulation of AdipoR1 expression in 3T3-L1 cells, but significantly up-regulated AdipoR2 mRNA level in a biphasic manner. | Insulin-regulated expression of adiponectin receptors in muscle and fat cells.
Sattar AA, Sattar R. | 04/27/2013 |
| Gene expression of adiponectin and AdipoR1/AdipoR2 receptors gradually increases during the wound healing process. | Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway.
Shibata S, Tada Y, Asano Y, Hau CS, Kato T, Saeki H, Yamauchi T, Kubota N, Kadowaki T, Sato S. | 12/8/2012 |
| The messenger RNA expression levels of hepatic adiponectin receptor (AdipoR)-1 and AdipoR2 and skeletal muscular AdipoR1 were up-regulated by tiliroside treatment. | Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.
Goto T, Teraminami A, Lee JY, Ohyama K, Funakoshi K, Kim YI, Hirai S, Uemura T, Yu R, Takahashi N, Kawada T. | 11/3/2012 |
| This study demonistrated that AdipoR2 is expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin. | AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin.
Klein I, Sanchez-Alavez M, Tabarean I, Schaefer J, Holmberg KH, Klaus J, Xia F, Marcondes MC, Dubins JS, Morrison B, Zhukov V, Sanchez-Gonzalez A, Mitsukawa K, Hadcock JR, Bartfai T, Conti B., Free PMC Article | 02/18/2012 |
| Adipoq signaling has a role in preimplantation embryo development and uterine receptivity. | Adiponectin and adiponectin receptors in the mouse preimplantation embryo and uterus.
Kim ST, Marquard K, Stephens S, Louden E, Allsworth J, Moley KH., Free PMC Article | 04/30/2011 |
| investigation of expression and localization of Adipor2 & Adipor1 during embryo development | Expression of adiponectin receptors and effects of adiponectin isoforms in mouse preimplantation embryos.
Čikoš Š, Burkuš J, Bukovská A, Fabian D, Rehák P, Koppel J. | 01/1/2011 |
| the adiponectin receptor 2 (AdipoR2) was differentially regulated by alcohol in the anterior cingulate cortex in a K-ras-dependent manner | A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake.
Repunte-Canonigo V, Berton F, Cottone P, Reifel-Miller A, Roberts AJ, Morales M, Francesconi W, Sanna PP., Free PMC Article | 09/6/2010 |
| Data suggest that low adiponectin receptors 1 and 2 in visceral adipocytes and adipose tissue and further suppression in adipose tissue of insulin-resistant animals indicate disturbed adiponectin bioactivity. | Low-abundant adiponectin receptors in visceral adipose tissue of humans and rats are further reduced in diabetic animals.
Bauer S, Weigert J, Neumeier M, Wanninger J, Schäffler A, Luchner A, Schnitzbauer AA, Aslanidis C, Buechler C. | 08/16/2010 |
| Liver steatosis is associated with downregulation of AdipoR2 and a reduction of AdipoR2 in the liver and with a reduction of serum adiponectin in the obese C57BL mouse. | Downregulation of adiponectin/AdipoR2 is associated with steatohepatitis in obese mice.
Peng Y, Rideout D, Rakita S, Sajan M, Farese R, You M, Murr MM. | 06/14/2010 |
| the expression of AdipoR2 and (mainly) AdipoR1 in the mouse adrenal cortex and the adrenocortical cell line Y-1 was detected. | Expression of adiponectin receptors in mouse adrenal glands and the adrenocortical Y-1 cell line: adiponectin regulates steroidogenesis.
Li P, Sun F, Cao HM, Ma QY, Pan CM, Ma JH, Zhang XN, Jiang H, Song HD, Chen MD. | 01/21/2010 |
| Results characterise the expression and interaction of adiponectin receptors 1 and 2 and adiponectin, respectively, in regulating the activity of growth hormone-secreting cells. | Adiponectin regulate growth hormone secretion via adiponectin receptor mediated Ca(2+) signalling in rat somatotrophs in vitro.
Steyn FJ, Boehme F, Vargas E, Wang K, Parkington HC, Rao JR, Chen C. | 01/21/2010 |
| results suggest that AdiR2 expression is regulated by palmitate via PPAR-alpha. | Regulation of adiponectin receptor 2 expression via PPAR-alpha in NIT-1 cells.
Jung TW, Lee MW, Lee YJ, Kim SM, Lee KT, Whang WK, Cheon HJ, Jeong YT, Chung KW, Cho JM, Kim DH, Jung TW. | 01/21/2010 |
| Adipor1 and Adipor2 were present in proopiomelanocortin and neuropeptide Y neurons in the arcuate nucleus. | Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons.
Guillod-Maximin E, Roy AF, Vacher CM, Aubourg A, Bailleux V, Lorsignol A, Pénicaud L, Parquet M, Taouis M. | 01/21/2010 |
| Gene expression of AdipoR2 is significantly lower in the liver ob obese mice. | Adiponectin receptor-1 expression is decreased in the pancreas of obese mice.
Wade TE, Mathur A, Lu D, Swartz-Basile DA, Pitt HA, Zyromski NJ. | 01/21/2010 |