| Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles. | Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles.
Dobbs OG, Wilson RHC, Newling K, Ainscough JF, Coverley D., Free PMC Article | 08/16/2023 |
| Prion-like domains drive CIZ1 assembly formation at the inactive X chromosome. | Prion-like domains drive CIZ1 assembly formation at the inactive X chromosome.
Sofi S, Williamson L, Turvey GL, Scoynes C, Hirst C, Godwin J, Brockdorff N, Ainscough J, Coverley D., Free PMC Article | 05/7/2022 |
| Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading. | Time-resolved structured illumination microscopy reveals key principles of Xist RNA spreading.
Rodermund L, Coker H, Oldenkamp R, Wei G, Bowness J, Rajkumar B, Nesterova T, Susano Pinto DM, Schermelleh L, Brockdorff N. | 06/26/2021 |
| CDKN1A interacting zinc finger protein 1 (Ciz1) knockout mice (Ciz1(DeltaE5/DeltaE5) ) lose residues encoded by exon 5 but may gain function from novel amino acid sequences. | Consequences of Cre-mediated deletion of Ciz1 exon 5 in mice.
Xiao J, Khan MM, Vemula S, Tian J, LeDoux MS., Free PMC Article | 06/22/2019 |
| It plays a critical role in DNA replication and cell-cycle progression at the G1/S checkpoint. | DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice.
Khan MM, Xiao J, Patel D, LeDoux MS., Free PMC Article | 09/29/2018 |
| CIZ1 is recruited to Xi in response to expression of X inactive-specific transcript (Xist) RNA during the earliest stages of X inactivation in embryonic stem cells and is dependent on the C-terminal nuclear matrix anchor domain of CIZ1 and the E repeats of Xist CIZ1-null mice, although viable, display fully penetrant female-specific lymphoproliferative disorder. | The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory.
Ridings-Figueroa R, Stewart ER, Nesterova TB, Coker H, Pintacuda G, Godwin J, Wilson R, Haslam A, Lilley F, Ruigrok R, Bageghni SA, Albadrani G, Mansfield W, Roulson JA, Brockdorff N, Ainscough JFX, Coverley D., Free PMC Article | 09/23/2017 |
| This study demonstrated that CIZ1 may be involved in the post-mitotic differentiation of neurons in response to external signals and changes in gene expression may compensate. | Motor phenotypes and molecular networks associated with germline deficiency of Ciz1.
Xiao J, Vemula SR, Xue Y, Khan MM, Kuruvilla KP, Marquez-Lona EM, Cobb MR, LeDoux MS., Free PMC Article | 05/6/2017 |
| CIZ1 is a kinase sensor that promotes initiation of DNA replication at low kinase levels, when in a hypophosphorylated state that is permissive for cyclin-A-CDK2 interaction and delivery to licensed origins. | Cyclin-A-CDK2-mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication.
Copeland NA, Sercombe HE, Wilson RH, Coverley D. | 01/16/2016 |
| results suggest that CIZ1 may play an important role in the progression of human prostate carcinoma and us which may be used as a therapeutic target in prostate cancer | Ciz1 promotes tumorigenicity of prostate carcinoma cells.
Liu T, Ren X, Li L, Yin L, Liang K, Yu H, Ren H, Zhou W, Jing H, Kong C. | 10/3/2015 |
| CIZ1 functions as a tumor suppressor in vivo. | CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo.
Nishibe R, Watanabe W, Ueda T, Yamasaki N, Koller R, Wolff L, Honda Z, Ohtsubo M, Honda H. | 07/27/2013 |
| CIZ1 interacts with germ-cell-specific cyclin A1. | Cancer-associated variant expression and interaction of CIZ1 with cyclin A1 in differentiating male germ cells.
Greaves EA, Copeland NA, Coverley D, Ainscough JF. | 12/8/2012 |
| glucocorticoid-responsive elements proximal to the Lcn2 promoter apparently functions to regulate both the Lcn2 gene and the distal Ciz1 gene. | Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions.
Hakim O, John S, Ling JQ, Biddie SC, Hoffman AR, Hager GL., Free PMC Article | 01/21/2010 |
| conditional exclusion of exon 4 influences the spatial distribution of the Ciz1 protein within the nucleus, showing that CIZ1 alternative splicing could influence organized patterns of DNA replication | Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1.
Rahman F, Ainscough JF, Copeland N, Coverley D. | 01/21/2010 |
| Ciz1 promotes DNA replication. | Ciz1 promotes mammalian DNA replication.
Coverley D, Marr J, Ainscough J. | 01/21/2010 |
| Ciz1 is composed of two functionally distinct domains: an N-terminal replication domain and a C-terminal nuclear matrix anchor | C-terminal domains deliver the DNA replication factor Ciz1 to the nuclear matrix.
Ainscough JF, Rahman FA, Sercombe H, Sedo A, Gerlach B, Coverley D. | 01/21/2010 |