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    STAT1 signal transducer and activator of transcription 1 [ Homo sapiens (human) ]

    Gene ID: 6772, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.

    The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
    Hong J, Li X, Hao Y, Xu H, Yu L, Meng Z, Zhang J, Zhu M.,

    11/7/2024
    STAT1 and STAT3 gain of function: clinically heterogenous immune regulatory disorders.

    STAT1 and STAT3 gain of function: clinically heterogenous immune regulatory disorders.
    Olbrich P, Freeman AF., Free PMC Article

    11/7/2024
    Regulation of STAT1 Signaling in Human Pancreatic beta-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?

    Regulation of STAT1 Signaling in Human Pancreatic β-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?
    Leslie KA, Lekka C, Richardson SJ, Russell MA, Morgan NG.

    10/1/2024
    Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjogren's syndrome: Novel biomarkers for disease activity and subsets.

    Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjögren's syndrome: Novel biomarkers for disease activity and subsets.
    Ritter J, Szelinski F, Aue A, Stefanski AL, Rincon-Arevalo H, Chen Y, Nitschke E, Dang VD, Wiedemann A, Schrezenmeier E, Lino AC, Dörner T.

    08/12/2024
    CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis.

    CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis.
    Yu SK, Yu T, Wang YM, Sun A, Liu J, Lu KH., Free PMC Article

    08/9/2024
    AIM2 inflammasome regulated by the IFN-gamma/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease.

    AIM2 inflammasome regulated by the IFN-γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease.
    Zhao Y, Liang B, Sheng S, Wang C, Jin B, Zhang X, Cheng Y, Shen C, Zheng F., Free PMC Article

    06/27/2024
    KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.

    KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.
    Yuan Q, Wu Y, Xue C, Zhao D, Wang H, Shen Y.

    06/21/2024
    Qualitative Immunoglobulin Deficiency Causes Bacterial Infections in Patients with STAT1 Gain-of-Function Mutations.

    Qualitative Immunoglobulin Deficiency Causes Bacterial Infections in Patients with STAT1 Gain-of-Function Mutations.
    Chen R, Mu H, Chen X, Tsumura M, Zhou L, Jiang X, Zhang Z, Tang X, Chen Y, Jia Y, Okada S, Zhao X, An Y.

    06/17/2024
    Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a therapeutic target for HP1alpha-positive intrahepatic cholangiocarcinoma.

    Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma.
    Xiong F, Wang D, Xiong W, Wang X, Huang WH, Wu GH, Liu WZ, Wang Q, Chen JS, Kuai YY, Wang B, Chen YJ., Free PMC Article

    06/6/2024
    STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma.

    STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma.
    Khan MT, Almas M, Malik N, Jalota A, Sharma S, Ali SA, Luthra K, Suri V, Suri A, Basak S, Seth P, Chosdol K, Sinha S.

    06/5/2024
    USP39 Promotes the Viability and Migration of Head and Neck Squamous Cell Carcinoma Cell by Regulating STAT1.

    USP39 Promotes the Viability and Migration of Head and Neck Squamous Cell Carcinoma Cell by Regulating STAT1.
    Hu Y, Wang Y, Hu W, Hu C, Wang B, Liu C, Deng A, Shen B, Wu K, Liu Y., Free PMC Article

    05/29/2024
    hsa_circ_0087100/hsa-miR-6743-5p affects Th1 cell differentiation by regulating STAT1 in diabetic retinopathy.

    hsa_circ_0087100/hsa-miR-6743-5p affects Th1 cell differentiation by regulating STAT1 in diabetic retinopathy.
    He S, Lai D, Ma C, Meng C, Cai C, Chen Q, Gu C, Qiu Q.

    03/29/2024
    Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-gamma signaling in squamous cancer.

    Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer.
    Jiang Y, Zheng Y, Zhang YW, Kong S, Dong J, Wang F, Ziman B, Gery S, Hao JJ, Zhou D, Zhou J, Ho AS, Sinha UK, Chen J, Zhang S, Yin C, Wei DD, Hazawa M, Pan H, Lu Z, Wei WQ, Wang MR, Koeffler HP, Lin DC, Jiang YY., Free PMC Article

    03/22/2024
    Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research.

    Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research.
    Asano T, Noma K, Mizoguchi Y, Karakawa S, Okada S.

    03/20/2024
    HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.

    HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.
    Zhang Y, Wang M, Ye L, Shen S, Zhang Y, Qian X, Zhang T, Yuan M, Ye Z, Cai J, Meng X, Qiu S, Liu S, Liu R, Jia W, Yang X, Zhang H, Zhong X, Gao P., Free PMC Article

    02/20/2024
    LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis.

    LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis.
    Zhao L, Pei R, Ding Y, Su Z, Li D, Zhu S, Xu L, Zhao H, Zhou W.

    02/8/2024
    RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-kappaB activation and ovarian cancer progression.

    RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote ROS-mediated NF-κB activation and ovarian cancer progression.
    Yu X, Zhao P, Luo Q, Wu X, Wang Y, Nan Y, Liu S, Gao W, Li B, Liu Z, Cui Z.

    02/5/2024
    [Knockdown of interferon-gamma inducible protein 30 (IFI30) inhibits the proliferation, invasion and migration of human glioma U251 cells by activating STAT1 and promotes their apoptosis].

    [Knockdown of interferon-γ inducible protein 30 (IFI30) inhibits the proliferation, invasion and migration of human glioma U251 cells by activating STAT1 and promotes their apoptosis].
    Ye J, Xu W, Chen T.

    01/29/2024
    AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-kappaB activation in oral squamous cell carcinoma.

    AIM2 promotes irradiation resistance, migration ability and PD-L1 expression through STAT1/NF-κB activation in oral squamous cell carcinoma.
    Chiu HW, Lee HL, Lee HH, Lu HW, Lin KY, Lin YF, Lin CH., Free PMC Article

    01/17/2024
    ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription through Genome-Wide Binding of Phosphorylated and Unphosphorylated Complexes to Common ISRE-Containing ISGs.

    ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription through Genome-Wide Binding of Phosphorylated and Unphosphorylated Complexes to Common ISRE-Containing ISGs.
    Nowicka H, Sekrecka A, Blaszczyk K, Kluzek K, Chang CY, Wesoly J, Lee CK, Bluyssen HAR., Free PMC Article

    01/11/2024
    Fatal COVID-19 Infection in Two Children with STAT1 Gain-of-Function.

    Fatal COVID-19 Infection in Two Children with STAT1 Gain-of-Function.
    Staines-Boone AT, Vignesh P, Tsumura M, de la Garza Fernández G, Tyagi R, Rawat A, Das J, Tomomasa D, Asano T, Hijikata A, Salazar-Gálvez Y, Kanegane H, Okada S, Reyes SOL.

    01/3/2024
    ESCO2 promotes hypopharyngeal carcinoma progression in a STAT1-dependent manner.

    ESCO2 promotes hypopharyngeal carcinoma progression in a STAT1-dependent manner.
    Hu J, Yan J, Chen Y, Li X, Yang L, Di H, Zhang H, Shi Y, Zhao J, Shi Y, Xu Y, Ren X, Wang Z., Free PMC Article

    11/20/2023
    STAT1 deficiency underlies a proinflammatory imprint of naive CD4[+] T cells in spondyloarthritis.

    STAT1 deficiency underlies a proinflammatory imprint of naive CD4(+) T cells in spondyloarthritis.
    Cherqaoui B, Crémazy F, Lauraine M, Shammas G, Said-Nahal R, Mambu Mambueni H, Costantino F, Fourmont M, Hulot A, Garchon HJ, Glatigny S, Araujo LM, Breban M., Free PMC Article

    11/10/2023
    The Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Breast Cancer Are Regulated by N-Linked Glycosylation-Dependent Activation of STAT3 and STAT1.

    The Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Breast Cancer Are Regulated by N-Linked Glycosylation-Dependent Activation of STAT3 and STAT1.
    Erlichman N, Meshel T, Baram T, Abu Raiya A, Horvitz T, Ben-Yaakov H, Ben-Baruch A., Free PMC Article

    11/7/2023
    STAT1 suppresses the transcriptional activity of TRIM21 in gastric cancer.

    STAT1 suppresses the transcriptional activity of TRIM21 in gastric cancer.
    Huo C, Gu Y, Wang D, Zhang X, Tang F, Zhao B, Liu T, He W, Li Y.

    11/6/2023
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