| The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression Without Missing Neurons. | The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression Without Missing Neurons.
Dienel SJ, Fish KN, Lewis DA., Free PMC Article | 07/6/2023 |
| Somatostatin Containing delta-Cell Number Is Reduced in Type-2 Diabetes. | Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes.
Kothegala L, Miranda C, Singh M, Krieger JP, Gandasi NR., Free PMC Article | 03/2/2023 |
| Somatostatin, Cortistatin and Their Receptors Exert Antitumor Actions in Androgen-Independent Prostate Cancer Cells: Critical Role of Endogenous Cortistatin. | Somatostatin, Cortistatin and Their Receptors Exert Antitumor Actions in Androgen-Independent Prostate Cancer Cells: Critical Role of Endogenous Cortistatin.
Sáez-Martínez P, Porcel-Pastrana F, Pérez-Gómez JM, Pedraza-Arévalo S, Gómez-Gómez E, Jiménez-Vacas JM, Gahete MD, Luque RM., Free PMC Article | 11/19/2022 |
| Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity. | Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity.
Flisher MF, Shin D, Huising MO., Free PMC Article | 04/16/2022 |
| LINC01133 hampers the development of gastric cancer through increasing somatostatin via binding to microRNA-576-5p. | LINC01133 hampers the development of gastric cancer through increasing somatostatin via binding to microRNA-576-5p.
Zhang L, Pan K, Zuo Z, Ye F, Cao D, Peng Y, Tang T, Li X, Zhou S, Duan L. | 03/26/2022 |
| Role of Somatostatin Signalling in Neuroendocrine Tumours. | Role of Somatostatin Signalling in Neuroendocrine Tumours.
Rogoza O, Megnis K, Kudrjavceva M, Gerina-Berzina A, Rovite V., Free PMC Article | 03/19/2022 |
| Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits. | Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits.
Yao HK, Guet-McCreight A, Mazza F, Moradi Chameh H, Prevot TD, Griffiths JD, Tripathy SJ, Valiante TA, Sibille E, Hay E. | 02/19/2022 |
| Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons. | Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons.
Racine AS, Michon FX, Laplante I, Lacaille JC., Free PMC Article | 02/5/2022 |
| MECHANISMS IN ENDOCRINOLOGY: The physiology of neuronostatin. | MECHANISMS IN ENDOCRINOLOGY: The physiology of neuronostatin.
Andersen MR, Suppli MP, Bagger JI, Christensen MB, Yosten GLC, Knop FK, Lund A. | 09/11/2021 |
| SST gene hypermethylation acts as a pan-cancer marker for pancreatic ductal adenocarcinoma and multiple other tumors: toward its use for blood-based diagnosis. | SST gene hypermethylation acts as a pan-cancer marker for pancreatic ductal adenocarcinoma and multiple other tumors: toward its use for blood-based diagnosis.
Manoochehri M, Wu Y, Giese NA, Strobel O, Kutschmann S, Haller F, Hoheisel JD, Moskalev EA, Hackert T, Bauer AS., Free PMC Article | 07/3/2021 |
| Somatostatin, a Presynaptic Modulator of Glutamatergic Signal in the Central Nervous System. | Somatostatin, a Presynaptic Modulator of Glutamatergic Signal in the Central Nervous System.
Pittaluga A, Roggeri A, Vallarino G, Olivero G., Free PMC Article | 06/26/2021 |
| Up-regulated ONECUT2 and down-regulated SST promote gastric cell migration, invasion, epithelial-mesenchymal transition and tumor growth in gastric cancer. | Up-regulated ONECUT2 and down-regulated SST promote gastric cell migration, invasion, epithelial-mesenchymal transition and tumor growth in gastric cancer.
Wang GH, Zhou YM, Yu Z, Deng JP, Liu SF, Wei CZ, Feng Y, Mao M, Wang Z. | 05/8/2021 |
| Metastatic pancreatic neuroendocrine tumors have decreased somatostatin expression and increased Akt signaling. | Metastatic pancreatic neuroendocrine tumors have decreased somatostatin expression and increased Akt signaling.
Tran CG, Scott AT, Li G, Sherman SK, Ear PH, Howe JR., Free PMC Article | 05/1/2021 |
| Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk. | Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk.
Anderson KM, Collins MA, Chin R, Ge T, Rosenberg MD, Holmes AJ., Free PMC Article | 08/29/2020 |
| SCN10A and SST were identified as biomarkers for Neuropathic pain (NP). In conclusion, our study showed the expression pattern of gene about NP. These identified biomarkers could serve as potential therapeutic targets for treating NP | Identification of novel therapeutic targets for neuropathic pain based on gene expression patterns.
Zhu D, Liu K, Wan CL, Lu J, Zhao HX. | 05/30/2020 |
| Studies indicate that the main functions of somatostatin in the gastrointestinal (GI) tract are connected with the inhibition of the intestinal motility and secretory activity [Review]. | Somatostatin as an Active Substance in the Mammalian Enteric Nervous System.
Gonkowski S, Rytel L., Free PMC Article | 02/15/2020 |
| BDNF messenger RNAs, which migrate to distal dendrites of pyramidal neurons, are selectively reduced, and their expression was highly correlated with Somatostatin expression in the prefrontal cortex of subjects with Major Depressive Disorder. | The Role of Dendritic Brain-Derived Neurotrophic Factor Transcripts on Altered Inhibitory Circuitry in Depression.
Oh H, Piantadosi SC, Rocco BR, Lewis DA, Watkins SC, Sibille E., Free PMC Article | 02/8/2020 |
| Report on an SST interactome analysis that made use of brain extracts as biological source material and incorporated advanced mass spectrometry workflows for the relative quantitation of SST binding proteins. The analysis revealed SST to predominantly bind several members of the P-type family of ATPases. | The human brain somatostatin interactome: SST binds selectively to P-type family ATPases.
Solarski M, Williams D, Mehrabian M, Wang H, Wille H, Schmitt-Ulms G., Free PMC Article | 02/8/2020 |
| Study in Han Chinese population revealed that rs3755792 and rs7624906 variants at SST in smoking population and rs3755792 in drinking population presented significant association with hypertension incidence. rs6032470 at GHRH had a statistical association with ischemic stroke incidence in smoking population. | Common variants at somatostatin are significantly associated with hypertension incidence in smoking and drinking populations.
Zhu H, Zhu L, Fang Z, Yang S, Chen Y, Jin Y, Zhao X, Shen C, Yao Y. | 08/24/2019 |
| SST-positive GABAergic neurons were clearly reduced in GABAergic neurons derived from induced pluripotent stem cells of patients with PARK2 mutations. | Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations.
Iwasawa C, Kuzumaki N, Suda Y, Kagawa R, Oka Y, Hattori N, Okano H, Narita M., Free PMC Article | 06/15/2019 |
| These findings suggest that some of the antiinflammatory effects of SSt against acute pancreatitis may be mediated by reducing the local proinflammatory cytokine secretion in the pancreas | Relationship between somatostatin and interleukin-6: A cross-sectional study in patients with acute pancreatitis.
Sliwinska-Mosson M, Marek G, Grzebieniak Z, Milnerowicz H. | 03/23/2019 |
| Higher levels of circulating N-terminal-prosomatostatin are associated with increased incidence of vascular dementia. | N-Terminal Prosomatostatin and Risk of Vascular Dementia.
Holm H, Nägga K, Nilsson ED, Ricci F, Cinosi E, Melander O, Hansson O, Bachus E, Magnusson M, Fedorowski A. | 03/16/2019 |
| Temporal changes in levels of circulating SST mirror the temporal changes in the incidence of migraine, particularly in women. The SST2 receptor agonist octreotide has been used with some success in migraine and cluster headache. Authors suggest that the withdrawal of descending tone in SST-containing neurons, might create a false pain signal and hence the headache of migraine. [Review] | Does somatostatin have a role to play in migraine headache?
Lambert GA, Zagami AS. | 09/29/2018 |
| By unbiased genome-wide DNA methylation profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR, SST, and ZIC1) associated with a 3q gain for the detection of cervical (pre)cancer | Genome-wide DNA Methylation Profiling Reveals Methylation Markers Associated with 3q Gain for Detection of Cervical Precancer and Cancer.
Verlaat W, Snijders PJF, Novianti PW, Wilting SM, De Strooper LMA, Trooskens G, Vandersmissen J, Van Criekinge W, Wisman GBA, Meijer CJLM, Heideman DAM, Steenbergen RDM. | 04/14/2018 |
| Somatostatin pancreatic Delta cells (D cells) locations have also been confirmed in animals and human [review]. | Somatostatin: One of the Rare Multifunctional Inhibitors of Mammalian Species.
Morisset J. | 03/10/2018 |