| Do SOD2 and SOD3 gene polymorphisms impact the oral health-related quality of life in Para athletes? | Do SOD2 and SOD3 gene polymorphisms impact the oral health-related quality of life in Para athletes?
Silveira ACJ, Guimarães LS, VON Held R, Silva EBD, Silveira FM, Oliveira Neto ZC, Scariot R, Winckler C, Küchler EC, Brancher JA, Antunes LAA, Antunes LS., Free PMC Article | 08/9/2024 |
| Clinical Correlation of Transcription Factor SOX3 in Cancer: Unveiling Its Role in Tumorigenesis. | Clinical Correlation of Transcription Factor SOX3 in Cancer: Unveiling Its Role in Tumorigenesis.
Del Puerto HL, Miranda APGS, Qutob D, Ferreira E, Silva FHS, Lima BM, Carvalho BA, Roque-Souza B, Gutseit E, Castro DC, Pozzolini ET, Duarte NO, Lopes TBG, Taborda DYO, Quirino SM, Elgerbi A, Choy JS, Underwood A., Free PMC Article | 07/16/2024 |
| ROR2 deficit may induce the tetralogy of Fallot via down-regulating of beta-catenin/SOX3/HSPA6 in vitro and in vivo. | ROR2 deficit may induce the tetralogy of Fallot via down-regulating of β-catenin/SOX3/HSPA6 in vitro and in vivo.
Guo R, Guo YZ, Zhou Q, Li G, Du Z, Shi Y, Xing Q., Free PMC Article | 12/20/2023 |
| A complex structural variant near SOX3 causes X-linked split-hand/foot malformation. | A complex structural variant near SOX3 causes X-linked split-hand/foot malformation.
de Boer E, Marcelis C, Neveling K, van Beusekom E, Hoischen A, Klein WM, de Leeuw N, Mantere T, Melo US, van Reeuwijk J, Smeets D, Spielmann M, Kleefstra T, van Bokhoven H, Vissers LELM., Free PMC Article | 05/30/2023 |
| Transcription factor SOX3 upregulated pro-apoptotic genes expression in human breast cancer. | Transcription factor SOX3 upregulated pro-apoptotic genes expression in human breast cancer.
Silva FHS, Underwood A, Almeida CP, Ribeiro TS, Souza-Fagundes EM, Martins AS, Eliezeck M, Guatimosim S, Andrade LO, Rezende L, Gomes HW, Oliveira CA, Rodrigues RC, Borges IT, Cassali GD, Ferreira E, Del Puerto HL. | 10/8/2022 |
| A SOX3 duplication and lumbosacral spina bifida in three generations. | A SOX3 duplication and lumbosacral spina bifida in three generations.
Butler KM, Fee T, DuPont BR, Dean JH, Stevenson RE, Lyons MJ. | 07/16/2022 |
| LINC00662 Promotes Proliferation and Invasion and Inhibits Apoptosis of Glioma Cells Through miR-483-3p/SOX3 Axis. | LINC00662 Promotes Proliferation and Invasion and Inhibits Apoptosis of Glioma Cells Through miR-483-3p/SOX3 Axis.
Yuan L, Zhang P, Lu Y, Zhang A, Chen X. | 06/25/2022 |
| Allelic Variants in Established Hypopituitarism Genes Expand Our Knowledge of the Phenotypic Spectrum. | Allelic Variants in Established Hypopituitarism Genes Expand Our Knowledge of the Phenotypic Spectrum.
Nakaguma M, Ferreira NGBP, Benedetti AFF, Madi MC, Silva JM, Li JZ, Ma Q, Bilge Ozel A, Fang Q, Narcizo AM, Cardoso LC, Montenegro LR, Funari MFA, Nishi MY, Arnhold IJP, Jorge AAL, Mendonca BB, Camper SA, Carvalho LR., Free PMC Article | 02/12/2022 |
| Serum proteome profiling reveals SOX3 as a candidate prognostic marker for gastric cancer. | Serum proteome profiling reveals SOX3 as a candidate prognostic marker for gastric cancer.
Shen J, Zhai J, Wu X, Xie G, Shen L., Free PMC Article | 05/1/2021 |
| Marked phenotypic variable expression among brothers with duplication of Xq27.1 involving the SOX3 gene. | Marked phenotypic variable expression among brothers with duplication of Xq27.1 involving the SOX3 gene.
Rosolowsky ET, Stein R, Marks SD, Leonard N. | 12/12/2020 |
| MiR-483 suppresses cell proliferation and promotes cell apoptosis by targeting SOX3 in breast cancer. | MiR-483 suppresses cell proliferation and promotes cell apoptosis by targeting SOX3 in breast cancer.
Cui K, Zhang H, Wang GZ. | 08/15/2020 |
| SOX3 duplication is a genomic imbalance involved in the pathogenesis of neural tube defects. | SOX3 duplication: A genetic cause to investigate in fetuses with neural tube defects.
Hureaux M, Ben Miled S, Chatron N, Coussement A, Bessières B, Egloff M, Mechler C, Stirnemann J, Tsatsaris V, Barcia G, Turleau C, Ville Y, Encha-Razavi F, Attie-Bitach T, Malan V. | 07/11/2020 |
| This is the largest series reported to date of unrelated patients with congenital hypopituitarism in association with Xq27.1 duplication encompassing SOX3. | Xq27.1 Duplication Encompassing SOX3: Variable Phenotype and Smallest Duplication Associated with Hypopituitarism to Date - A Large Case Series of Unrelated Patients and a Literature Review.
Arya VB, Chawla G, Nambisan AKR, Muhi-Iddin N, Vamvakiti E, Ajzensztejn M, Hulse T, Ferreira Pinto C, Lahiri N, Bint S, Buchanan CR, Kapoor RR. | 07/11/2020 |
| SOX3 can promote the malignant behavior of glioblastoma cells. | SOX3 can promote the malignant behavior of glioblastoma cells.
Marjanovic Vicentic J, Drakulic D, Garcia I, Vukovic V, Aldaz P, Puskas N, Nikolic I, Tasic G, Raicevic S, Garros-Regulez L, Sampron N, Atkinson MJ, Anastasov N, Matheu A, Stevanovic M. | 06/1/2019 |
| This is the first study to report that the rare SOX3 missense variant associated with hypopituitarism possibly due to increased activation of SOX3 target genes and disregulation of beta-catenin target genes. | Increased transactivation and impaired repression of β-catenin-mediated transcription associated with a novel SOX3 missense mutation in an X-linked hypopituitarism pedigree with modest growth failure.
Yu T, Chang G, Cheng Q, Yao R, Li J, Xu Y, Li G, Ding Y, Qing Y, Li N, Shen Y, Wang X, Wang J. | 05/11/2019 |
| Pathogenic missense mutation in SOX3 gene is associated with intellectual disability, microphthalmia, coloboma, hypopituitarism, facial dysmorphology and dental anomalies, including microcephaly, retrognathia and a solitary median maxillary central incisor amongst other features. | A complex phenotype in a family with a pathogenic SOX3 missense variant.
Jelsig AM, Diness BR, Kreiborg S, Main KM, Larsen VA, Hove H. | 09/22/2018 |
| our data indicate that SOX3 may serve as an oncogene in osteosarcoma | Downregulation of SOX3 leads to the inhibition of the proliferation, migration and invasion of osteosarcoma cells.
Guo Y, Yin J, Tang M, Yu X. | 08/25/2018 |
| deletion of the SOX3 gene may have a role in intellectual disability with hemophilia B | Study of six patients with complete F9 deletion characterized by cytogenetic microarray: role of the SOX3 gene in intellectual disability.
Jourdy Y, Chatron N, Carage ML, Fretigny M, Meunier S, Zawadzki C, Gay V, Negrier C, Sanlaville D, Vinciguerra C. | 12/30/2017 |
| Results show that SOX3 is upregulated in human osteosarcoma (OS) tissues and provide evidence that SOX3 promotes migration, invasiveness, and EMT in OS cells via transcriptional activation of Snail1 expression. | Sex-determining region Y-box protein 3 induces epithelial-mesenchymal transition in osteosarcoma cells via transcriptional activation of Snail1.
Qiu M, Chen D, Shen C, Shen J, Zhao H, He Y., Free PMC Article | 12/16/2017 |
| we provide a first map of the epigenetic landscape of SOX3 in pluripotent cells and during the early phases of neural differentiation. We found SOX3 gene to be non methylated from undifferentiated NT2/D1 to cells committed towards neural lineage. | Epigenetic regulation of human SOX3 gene expression during early phases of neural differentiation of NT2/D1 cells.
Topalovic V, Krstic A, Schwirtlich M, Dolfini D, Mantovani R, Stevanovic M, Mojsin M., Free PMC Article | 10/21/2017 |
| These findings demonstrate the novel mechanism by which Sox3 contributes to endometrial cancer stem cell invasion and suggest that repression of Sox3 by microRNA-194 may have therapeutic potential to suppress endometrial carcinoma metastasis. The cancer stem cell marker, CD133, might be the surface marker of endometrial cancer stem cell. | Overexpression of microRNA-194 suppresses the epithelial-mesenchymal transition in targeting stem cell transcription factor Sox3 in endometrial carcinoma stem cells.
Gong B, Yue Y, Wang R, Zhang Y, Jin Q, Zhou X. | 06/24/2017 |
| Data indicate that SRY-box 3 transcription factor SOX-3 targets Src kinase in epithelial ovarian cancer (EOC) cells. | Sex-determining region Y-box3 (SOX3) functions as an oncogene in promoting epithelial ovarian cancer by targeting Src kinase.
Yan Q, Wang F, Miao Y, Wu X, Bai M, Xi X, Feng Y. | 02/25/2017 |
| SOX3 overdosage permits normal sex development in 46,XX individuals with random X inactivation. | SOX3 Overdosage Permits Normal Sex Development in Females with Random X Inactivation.
Igarashi M, Mikami H, Katsumi M, Miyado M, Izumi Y, Ogata T, Fukami M. | 07/16/2016 |
| Translocations interrupting this region may also affect the gonadal development, possibly depending on the chromatin context of the recipient chromosome. SOX3 duplications may substitute SRY in some XX subjects | Testis development in the absence of SRY: chromosomal rearrangements at SOX9 and SOX3.
Vetro A, Dehghani MR, Kraoua L, Giorda R, Beri S, Cardarelli L, Merico M, Manolakos E, Parada-Bustamante A, Castro A, Radi O, Camerino G, Brusco A, Sabaghian M, Sofocleous C, Forzano F, Palumbo P, Palumbo O, Calvano S, Zelante L, Grammatico P, Giglio S, Basly M, Chaabouni M, Carella M, Russo G, Bonaglia MC, Zuffardi O., Free PMC Article | 04/30/2016 |
| Screening for SOX3 should be advised not only for hypopituitary patients with an ectopic posterior pituitary, but also for those with a structurally normal pituitary | SOX3 deletion in mouse and human is associated with persistence of the craniopharyngeal canal.
Alatzoglou KS, Azriyanti A, Rogers N, Ryan F, Curry N, Noakes C, Bignell P, Hall GW, Littooij AS, Saunders D, Thomas P, Stewart H, Dattani MT. | 10/10/2015 |