| Silencing CXCL16 alleviate neuroinflammation and M1 microglial polarization in mouse brain hemorrhage model and BV2 cell model through PI3K/AKT pathway. | Silencing CXCL16 alleviate neuroinflammation and M1 microglial polarization in mouse brain hemorrhage model and BV2 cell model through PI3K/AKT pathway.
Dingyi L, Libin H, Jifeng P, Ding Z, Yulong L, Zhangyi W, Yunong Y, Qinghua W, Feng L. | 08/14/2024 |
| CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8[+] T cells in diabetic autoimmunity. | CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8(+) T cells in diabetic autoimmunity.
Srivastava N, Hu H, Peterson OJ, Vomund AN, Stremska M, Zaman M, Giri S, Li T, Lichti CF, Zakharov PN, Zhang B, Abumrad NA, Chen YG, Ravichandran KS, Unanue ER, Wan X., | 08/6/2024 |
| CXCL16 exacerbates Pseudomonas aeruginosa keratitis by promoting neutrophil activation. | CXCL16 exacerbates Pseudomonas aeruginosa keratitis by promoting neutrophil activation.
Wu J, Wang W, Yuan F, Zheng J, Zhang W, Guo H, Wang L, Dai C, Han F, Wu X, Gao J. | 01/29/2024 |
| CXCL16 Promotes Ly6Chigh Monocyte Infiltration and Impairs Heart Function after Acute Myocardial Infarction. | CXCL16 Promotes Ly6Chigh Monocyte Infiltration and Impairs Heart Function after Acute Myocardial Infarction.
Zhang J, Hao W, Zhang J, Li T, Ma Y, Wang Y, Li X, Cui W, Du J. | 03/9/2023 |
| Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer's disease. | Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer's disease.
Li X, Zhang DF, Bi R, Tan LW, Chen X, Xu M, Yao YG., Free PMC Article | 02/11/2023 |
| CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis. | CXCL16 inhibits epithelial regeneration and promotes fibrosis during the progression of radiation enteritis.
Cui Y, Wu H, Liu Z, Ma T, Liang W, Zeng Q, Chen D, Qin Q, Huang B, Wang MH, Huang X, He Y, Kuang Y, Sugimoto S, Sato T, Wang L. | 01/21/2023 |
| Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination. | Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination.
Rosen SF, Soung AL, Yang W, Ai S, Kanmogne M, Davé VA, Artyomov M, Magee JA, Klein RS., Free PMC Article | 10/15/2022 |
| CXCL16 may be a predisposing factor to atherosclerosis: An animal study. | CXCL16 may be a predisposing factor to atherosclerosis: An animal study.
Zhao J, Yang M, Wu J. | 01/15/2022 |
| Evolutionary analysis of chemokine CXCL16 and its receptor CXCR6 in murine rodents. | Evolutionary analysis of chemokine CXCL16 and its receptor CXCR6 in murine rodents.
He D, Hu J, Yang R, Zeng B, Yang D, Li D, Zhang M, Yang M, Ni Q, Ning R, Fan X, Li X, Mao X, Li Y. | 09/4/2021 |
| An immunomodulatory role for the Mycobacterium tuberculosis Acr protein in the formation of the tuberculous granuloma. | An immunomodulatory role for the Mycobacterium tuberculosis Acr protein in the formation of the tuberculous granuloma.
Healy EF, Goering LM, Hauser CR, King PJ. | 07/17/2021 |
| significantly upregulated in pulmonary fibrosis model | CXCL16 Induces the Progression of Pulmonary Fibrosis through Promoting the Phosphorylation of STAT3.
Zuo S, Zhu Z, Liu Y, Li H, Song S, Yin S., Free PMC Article | 04/4/2020 |
| IL-33 and CXCL16, but not IL-25 or CCL25, directly induced group 2 innate lymphoid cell migration. | Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma: a potential role for the chemokine CXCL16.
Li Y, Chen S, Chi Y, Yang Y, Chen X, Wang H, Lv Z, Wang J, Yuan L, Huang P, Huang K, Corrigan CJ, Wang W, Ying S., Free PMC Article | 01/18/2020 |
| CXCL16/CXCR6 signaling axis plays a functional role in metabolic syndrome endothelial dysfunction and abdominal aortic aneurysm formation. | Functional role of endothelial CXCL16/CXCR6-platelet-leucocyte axis in angiotensin II-associated metabolic disorders.
Collado A, Marques P, Escudero P, Rius C, Domingo E, Martinez-Hervás S, Real JT, Ascaso JF, Piqueras L, Sanz MJ. | 10/26/2019 |
| In conclusion, Cxcl16 expressed in pancreatic acini contributes to the development of acinar cell necrosis through the induction of Ccl9 and subsequent neutrophil infiltration. | Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice.
Sakuma Y, Kodama Y, Eguchi T, Uza N, Tsuji Y, Shiokawa M, Maruno T, Kuriyama K, Nishikawa Y, Yamauchi Y, Tsuda M, Ueda T, Matsumori T, Morita T, Tomono T, Kakiuchi N, Mima A, Sogabe Y, Marui S, Kuwada T, Okada A, Watanabe T, Nakase H, Chiba T, Seno H., Free PMC Article | 10/19/2019 |
| the results of the present study suggested that CXCL16 may regulate the TRL4/NFkappaB/CXCL16 signaling pathway, and that miR146a and miR146b may negatively regulate CXCL16 via this pathway in atherosclerosis in vivo. | Associations of CXCL16, miR‑146a and miR‑146b in atherosclerotic apolipoprotein E‑knockout mice.
Ma AJ, Zhu XY, Yang SN, Pan XD, Wang T, Wang Y, Xiao X, Liu SH. | 11/10/2018 |
| Inflammation accelerates renal tubulointerstitial lesions in mouse model of diabetic nephropathy by increasing the activity of CXCL16 pathway. | Inflammation-activated CXCL16 pathway contributes to tubulointerstitial injury in mouse diabetic nephropathy.
Hu ZB, Ma KL, Zhang Y, Wang GH, Liu L, Lu J, Chen PP, Lu CC, Liu BC., Free PMC Article | 10/6/2018 |
| CXCL16 increases the frequency of the miniature excitatory synaptic currents (mEPSCs) and reduces the PPR of evoked excitatory transmission, indicating that the chemokine also modulates and enhances the release of glutamate. | The chemokine CXCL16 modulates neurotransmitter release in hippocampal CA1 area.
Di Castro MA, Trettel F, Milior G, Maggi L, Ragozzino D, Limatola C., Free PMC Article | 06/16/2018 |
| results indicate that CXCL16 plays a key role in the pathogenesis of renal injury and fibrosis in salt-sensitive hypertension through regulation of bone marrow-derived fibroblast accumulation and macrophage and T cell infiltration. | CXCL16 Deficiency Attenuates Renal Injury and Fibrosis in Salt-Sensitive Hypertension.
Liang H, Ma Z, Peng H, He L, Hu Z, Wang Y., Free PMC Article | 05/12/2018 |
| Data indicate that chemokine C-X-C ligand 16 (CXCL16) is a critical regulator of liver immune response to acetaminophen (APAP)-induced hepatotoxicity, suggesting a potential strategy for the treatment of drug-induced acute liver failure by targeting CXCL16. | CXCL16 deficiency attenuates acetaminophen-induced hepatotoxicity through decreasing hepatic oxidative stress and inflammation in mice.
Wang H, Shao Y, Zhang S, Xie A, Ye Y, Shi L, Jin L, Pan X, Lin Z, Li X, Yang S. | 04/14/2018 |
| CXCL16 plays a crucial role in the pathogenesis of cisplatin-induced acute kidney injury through regulation of apoptosis and inflammation. | CXCL16 regulates cisplatin-induced acute kidney injury.
Liang H, Zhang Z, He L, Wang Y., Free PMC Article | 12/30/2017 |
| These findings suggest that the CXCL16 gene product promotes inflammatory factors and cell infiltration factors, and inhibits the expression of antioxidant factors to accelerate the development of DN, and CXCL16 deficiency attenuates DN may be involved in the AKT signaling pathway. | CXCL16 deficiency attenuates diabetic nephropathy through decreasing oxidative stress and inflammation.
Ye Y, Chen Q, Li J, Jin L, Zheng J, Li X, Lin Z, Gong F. | 09/16/2017 |
| Results indicate that CXCL16 plays a pivotal role in the pathogenesis of renal artery stenosis-induced renal injury and fibrosis through regulation of bone marrow-derived fibroblast accumulation and macrophage and T-cell infiltration. | CXCL16 regulates renal injury and fibrosis in experimental renal artery stenosis.
Ma Z, Jin X, He L, Wang Y., Free PMC Article | 07/1/2017 |
| Simvastatin exerts a protective effect on renal function and structure in mice with ADR nephropathy which related to the decreasing expression of CXCL16 in glomerular podocytes followed by the decreasing endocytosis of ox-LDL in podocytes and inhibition of NF-kappaB pathway activation. | Simvastatin ameliorates renal lipidosis through the suppression of renal CXCL16 expression in mice with adriamycin-induced nephropathy.
Wang C, Li Q, Zhen J, Xu Y, Sun S., Free PMC Article | 11/12/2016 |
| These results indicate that MEK inhibitor diminishes Nasopharyngeal carcinoma cell proliferation and NPC-induced osteoclastogenesis via modulating CCL2 and CXCL16 expressions. | MEK inhibitor diminishes nasopharyngeal carcinoma (NPC) cell growth and NPC-induced osteoclastogenesis via modulating CCL2 and CXCL16 expressions.
Zhu Y, Zou C, Zhang Z, Qian CN, Yang X, Shi J, Xia Y, Zhang J, Lu Y. | 04/2/2016 |
| Serum CXCL16 is increased in severe pancreatitis with infected pancreatic necrosis and identifies patients who benefit from surgical necrosectomy | The chemokine ligand CXCL16 is an indicator of bacterial infection in necrotizing pancreatitis.
Wittel UA, Schmidt AI, Poxleitner PJ, Seifert GJ, Chikhladze S, Puolakkainen P, Hopt UT, Kylänpää L. | 12/26/2015 |