| The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis. | The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis.
Yang T, Hei R, Li X, Ma T, Shen Y, Liu C, He W, Zhu L, Gu Y, Hu Y, Wei W, Shen Y., Free PMC Article | 08/2/2023 |
| Neuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats via the neuropeptide Y receptor type 2/mitogen-activated protein kinase axis. | Neuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats via the neuropeptide Y receptor type 2/mitogen-activated protein kinase axis.
Yan W, Liu W, Wu J, Wu L, Xuan S, Wang W, Shang A., Free PMC Article | 05/7/2022 |
| NPY and Y1 were expressed by pulmonary intravascular and intraalveolar leukocytes. Y1 was up-regulated by pulmonary intravascular and intraalveolar leukocytes during allograft rejection while Y2 could not be detected. | Non-neuronal neuropeptide Y and its receptors during acute rejection of rat pulmonary allografts.
Schmitz J, Zakrzewicz A, Wilker S, Kuncová J, Hecker A, Grau V, Padberg W, Holler JPN. | 02/10/2018 |
| NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage | Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats.
Domin H, Przykaza Ł, Jantas D, Kozniewska E, Boguszewski PM, Śmiałowska M. | 11/11/2017 |
| Our data indicate that Y2 receptors are not only located at nerve terminals but also along fiber tracts and are there functionally coupled to G-proteins. | Effective G-protein coupling of Y2 receptors along axonal fiber tracts and its relevance for epilepsy.
Dum E, Fürtinger S, Gasser E, Bukovac A, Drexel M, Tasan R, Sperk G. | 03/11/2017 |
| In the hippocampus and mossy fiber pathway, limbic kindling-induced de novo expression of the NPY Y2 receptor. | Limbic but not non-limbic kindling impairs conditioned fear and promotes plasticity of NPY and its Y2 receptor.
Botterill JJ, Guskjolen AJ, Marks WN, Caruncho HJ, Kalynchuk LE. | 06/28/2016 |
| The blockade of peripheral NPY Y2 receptor by specific antagonist had no effect on baroreceptor reflex, baseline Systolic blood pressure and heart rate in STZ-induced diabetic rats with hyperlipidemia. | Blockage of peripheral NPY Y1 and Y2 receptors modulates barorefex sensitivity of diabetic rats.
Liu J, Wang N, Xie F, Sun LH, Chen QX, Ye JH, Cai BZ, Yang BF, Ai J. | 09/21/2013 |
| Data suggest that effects of neuropeptide Y (NPY) on hepatic VLDL-triglyceride secretion (i.e., occur via NPY receptor 2) can be dissociated from effects on feeding behavior (i.e., occur via NPY receptor 1); studies used selective agonists. | Central nervous system neuropeptide Y signaling via the Y1 receptor partially dissociates feeding behavior from lipoprotein metabolism in lean rats.
Rojas JM, Stafford JM, Saadat S, Printz RL, Beck-Sickinger AG, Niswender KD., Free PMC Article | 03/2/2013 |
| This study indicates distinct subset- and cytokine-specific in vivo effects induced by an NPY Y(2) receptor specific treatment after a short-term LPS challenge. | Distinct effects of NPY13-36, a specific NPY Y2 agonist, in a model of rodent endotoxemia on leukocyte subsets and cytokine levels.
Stadler J, Le TP, Haas P, Nave H. | 03/31/2012 |
| Data that iv NPY 13-36 administration stimulates ventilation and arterial blood pressure via peripheral Y2 receptors. | Activation of neuropeptide Y(2) receptors exerts an excitatory action on cardio-respiratory variables in anaesthetized rats.
Kaczyńska K, Szereda-Przestaszewska M. | 12/10/2011 |
| present findings suggest the existence of a facilitatory effect of GAL(1-15) mediated via Galanin receptors on the NPY Y2 receptor subtype and its cardiovascular function within the nucleus of the solitary tract | The Galanin N-terminal fragment (1-15) interacts with neuropeptide Y in central cardiovascular control: Involvement of the NPY Y2 receptor subtype.
Díaz-Cabiale Z, Parrado C, Narváez M, Millón C, Puigcerver A, Fuxe K, Narváez JA. | 01/29/2011 |
| Report binding and pharmacology of neuropeptide Y Y2 receptor antagonist JNJ-31020028. | In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor.
Shoblock JR, Welty N, Nepomuceno D, Lord B, Aluisio L, Fraser I, Motley ST, Sutton SW, Morton K, Galici R, Atack JR, Dvorak L, Swanson DM, Carruthers NI, Dvorak C, Lovenberg TW, Bonaventure P. | 03/1/2010 |
| BIIE0246, an antagonist for neuropeptide Y2 receptor , attenuated the suppression of Atrial Natriuretic Factor release by peptide YY. | Different regulation of atrial ANP release through neuropeptide Y2 and Y4 receptors.
Piao FL, Yuan K, Bai GY, Han JH, Park WH, Kim SH., Free PMC Article | 01/21/2010 |
| abundant Y1 and Y2 receptor activation in the rat brain | Functional autoradiography of neuropeptide Y Y1 and Y2 receptor subtypes in rat brain using agonist stimulated [35S]GTPgammaS binding.
Shaw JL, Gackenheimer SL, Gehlert DR. | 01/21/2010 |
| In substantia gelatinosa neurons in spinal cord slices from adult rats, we find that NPY acts via presynaptic Y2 receptors to attenuate excitatory postsynaptic currents (EPSCs) | Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation.
Moran TD, Colmers WF, Smith PA. | 01/21/2010 |
| RT-PCR and in vitro adhesion studies provided evidence for a NPY Y2 receptor-mediated effect on monocytes. Thus, NPY treatment has profound receptor-specific effects on the migration and adhesion of leukocytes under endotoxemic conditions. | Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation.
Nave H, Bedoui S, Moenter F, Steffens J, Felies M, Gebhardt T, Straub RH, Pabst R, Dimitrijevic M, Stanojevic S, von Hörsten S. | 01/21/2010 |
| Neuropeptide Y2 receptor is found mostly in granule cells of the internal granule cell layer of the cerebellum during postnatal development. | The neuropeptide Y receptors, Y1 and Y2, are transiently and differentially expressed in the developing cerebellum.
Neveu I, Rémy S, Naveilhan P. | 01/21/2010 |
| Neuropeptide Y-Y2 receptors are involved in the regulation of the anxiety response in the amygdala. | Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala.
Sajdyk TJ, Schober DA, Smiley DL, Gehlert DR. | 01/21/2010 |
| data reveal an NPY Y1 and Y2/Y5 receptor interaction in NPY-induced modulation of macrophage functions related to inflammation | Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors.
Dimitrijević M, Stanojević S, Vujić V, Beck-Sickinger A, von Hörsten S. | 01/21/2010 |