| Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma. | Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma.
Sundaramoorthy S, Colombo DF, Sanalkumar R, Broye L, Balmas Bourloud K, Boulay G, Cironi L, Stamenkovic I, Renella R, Kuttler F, Turcatti G, Rivera MN, Mühlethaler-Mottet A, Bardet AF, Riggi N., Free PMC Article | 09/20/2024 |
| BMX controls 3betaHSD1 and sex steroid biosynthesis in cancer. | BMX controls 3βHSD1 and sex steroid biosynthesis in cancer.
Li X, Berk M, Goins C, Alyamani M, Chung YM, Wang C, Patel M, Rathi N, Zhu Z, Willard B, Stauffer S, Klein E, Sharifi N., Free PMC Article | 01/21/2023 |
| Linc00173 upregulated Etk through functioning as a competitive endogenous RNA (ceRNA) by "sponging" miRNA-218 and led to the upregulation of GSKIP and NDRG1, resulting in the translocation of beta-catenin. Importantly, expression analysis revealed that both Linc00173 and Etk were upregulated in SCLC patient samples and exhibiting positive Linc00173/Etk correlation | Linc00173 promotes chemoresistance and progression of small cell lung cancer by sponging miR-218 to regulate Etk expression.
Zeng F, Wang Q, Wang S, Liang S, Huang W, Guo Y, Peng J, Li M, Zhu W, Guo L. | 04/18/2020 |
| tyrosine kinase BMX is negatively regulated by androgen and contributes to castration-resistant prostate cancer by enhancing the phosphorylation and activation of multiple receptor tyrosine kinases following androgen deprivation therapy | BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer.
Chen S, Cai C, Sowalsky AG, Ye H, Ma F, Yuan X, Simon NI, Gray NS, Balk SP., Free PMC Article | 10/12/2019 |
| Epithelial and endothelial tyrosine kinase (Etk) interacts with 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) to promote small-cell lung cancer (SCLC) chemoresistance through regulation of autophagy. | Etk Interaction with PFKFB4 Modulates Chemoresistance of Small-cell Lung Cancer by Regulating Autophagy.
Wang Q, Zeng F, Sun Y, Qiu Q, Zhang J, Huang W, Huang J, Huang X, Guo L. | 09/28/2019 |
| results demonstrate that hypoxia-dependent upregulation of BMX contributes to therapeutic resistance through a compensatory prosurvival signaling mechanism. These results also reveal the role of off-target drug effects on tumor microenvironment and development of acquired drug resistance. | Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia.
van Oosterwijk JG, Buelow DR, Drenberg CD, Vasilyeva A, Li L, Shi L, Wang YD, Finkelstein D, Shurtleff SA, Janke LJ, Pounds S, Rubnitz JE, Inaba H, Pabla N, Baker SD., Free PMC Article | 05/11/2019 |
| These results suggested that BMX can promote cell proliferation through PI3K/AKT/mTOR and STAT3 signaling pathways in cervical cancer cells. | BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways.
Li Y, Cui N, Zheng PS, Yang WT., Free PMC Article | 04/28/2018 |
| The studies suggested that BMXDeltaN might play roles in lung tumorigenicity, with expression of BMXDeltaN promoting cell growth, cell migration, and cell transformation. | A novel BMX variant promotes tumor cell growth and migration in lung adenocarcinoma.
Wang Y, Xia J, Fang Z, Li F, Li D, Wang Z, Feng Y, Zhang J, Chen H, Ji H, Liu H., Free PMC Article | 03/10/2018 |
| results demonstrate that cleaved BMX is a novel N-end rule substrate, and its degradation exhibits a novel interplay between substrate phosphorylation and N-end rule degradation, revealing an increasing complex regulatory network of apoptotic proteolytic signaling cascades. | Phosphorylation Impacts N-end Rule Degradation of the Proteolytically Activated Form of BMX Kinase.
Eldeeb MA, Fahlman RP., Free PMC Article | 05/27/2017 |
| Data indicate that EPHA3 is involved in regulating the multidrug resistance (MDR) of small cell lung cancer (SCLC) via PI3K/BMX/STAT3 signaling and may be a therapeutic target in SCLC. | EPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway.
Peng J, Wang Q, Liu H, Ye M, Wu X, Guo L., Free PMC Article | 02/18/2017 |
| BMX directly inhibits a core component of the intrinsic apoptosis machinery opens opportunities to improve the efficacy of existing chemotherapy by potentiating BAK-driven cell death in cancer cells. | BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs.
Fox JL, Storey A., Free PMC Article | 01/30/2016 |
| Report BMX-ARHGAP gene fusion in gastric cardia adenocarcinoma. | Identification of a novel gene fusion (BMX-ARHGAP) in gastric cardia adenocarcinoma.
Xu X, Xu L, Gao F, Wang J, Ye J, Zhou M, Zhu Y, Tao L., Free PMC Article | 12/5/2015 |
| These findings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI. | The influence of BMX gene polymorphisms on clinical symptoms after mild traumatic brain injury.
Wang YJ, Hsu YW, Chang CM, Wu CC, Ou JC, Tsai YR, Chiu WT, Chang WC, Chiang YH, Chen KY., Free PMC Article | 01/17/2015 |
| BMX is an antiapoptotic downstream effector of PI3K, independent of AKT. | BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.
Potter DS, Kelly P, Denneny O, Juvin V, Stephens LR, Dive C, Morrow CJ., Free PMC Article | 12/6/2014 |
| The effects of dietary K(+) on Bmx were more pronounced | Sodium and potassium regulate endothelial phospholipase C-γ and Bmx.
Ying WZ, Aaron KJ, Sanders PW., Free PMC Article | 09/27/2014 |
| Overexpression of ETK is associated with the malignancy and disease progression of renal cell carcinoma. | The expression and role of tyrosine kinase ETK/BMX in renal cell carcinoma.
Zhuang J, Tu X, Cao K, Guo S, Mao X, Pan J, Huang B, Chen X, Gao Y, Qiu S., Free PMC Article | 08/30/2014 |
| This review characterizes the role of BMX in inflamamtion, cardiovascular disease and cancer. | BMX and its role in inflammation, cardiovascular disease, and cancer.
Cenni B, Gutmann S, Gottar-Guillier M. | 07/28/2012 |
| Etk/BMX may play a role in protection of NPC cells from apoptosis. | Tyrosine kinase Etk/BMX protects nasopharyngeal carcinoma cells from apoptosis induced by radiation.
Zhang Z, Zhu W, Zhang J, Guo L. | 07/23/2011 |
| study concludes that BMX is an essential component of inflammatory cytokine signaling and that catalytic, as well as noncatalytic functions of BMX are involved | The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner.
Gottar-Guillier M, Dodeller F, Huesken D, Iourgenko V, Mickanin C, Labow M, Gaveriaux S, Kinzel B, Mueller M, Alitalo K, Littlewood-Evans A, Cenni B. | 07/9/2011 |
| Deregulation of ETK may attribute to the elevated activity of STAT3 and AKT frequently detected in bladder cancer. | Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy.
Guo S, Sun F, Guo Z, Li W, Alfano A, Chen H, Magyar CE, Huang J, Chai TC, Qiu S, Qiu Y., Free PMC Article | 07/9/2011 |
| BMX is associated with multi-drug resistance of K562/HHT cell line. | [Changes of gene expression profile in homoharringtonine-induced leukemia multi-drug resistant cell line K562/HHT].
Yu XL, Liu Y, Wang JD, Kong DX, Chen CY. | 06/18/2011 |
| Constitutively active STAT3 rescued the effects of BMX downregulation, supporting that BMX signals through STAT3 in glioblastoma stem cells (GSCs). | Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.
Guryanova OA, Wu Q, Cheng L, Lathia JD, Huang Z, Yang J, MacSwords J, Eyler CE, McLendon RE, Heddleston JM, Shou W, Hambardzumyan D, Lee J, Hjelmeland AB, Sloan AE, Bredel M, Stark GR, Rich JN, Bao S., Free PMC Article | 06/18/2011 |
| possible role in regulation of vesicle trafficking | Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking.
Yang J, Kim O, Wu J, Qiu Y. | 03/10/2011 |
| Investigate Bmx mediates VEGF-dependent lymphangiogenic signaling. | Functional analyses of the bone marrow kinase in the X chromosome in vascular endothelial growth factor-induced lymphangiogenesis.
Jones D, Xu Z, Zhang H, He Y, Kluger MS, Chen H, Min W., Free PMC Article | 01/1/2011 |
| by preventing binding of Etk/Bmx to PAR(1) -C-tail, hPar1 oncogenic properties are abrogated | Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: signaling partners, hierarchy and physiological significance.
Cohen I, Maoz M, Turm H, Grisaru-Granovsky S, Maly B, Uziely B, Weiss E, Abramovitch R, Gross E, Barzilay O, Qiu Y, Bar-Shavit R., Free PMC Article | 09/6/2010 |