| cGMP-dependent kinase 2, Na[+]/H[+] exchanger NHE3, and PDZ-adaptor NHERF2 co-assemble in apical membrane microdomains. | cGMP-dependent kinase 2, Na(+)/H(+) exchanger NHE3, and PDZ-adaptor NHERF2 co-assemble in apical membrane microdomains.
Luo M, Liu Y, Nikolovska K, Riederer B, Patrucco E, Hofmann F, Seidler U. | 04/27/2024 |
| NHERF2 and NHERF3 have overlapping roles in NHE3 stimulation by LPA and inhibition by elevated Ca(2+) and cGMP. | Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca(2+), cGMP, and lysophosphatidic acid.
Avula LR, Chen T, Kovbasnjuk O, Donowitz M., Free PMC Article | 03/2/2019 |
| LRBA deficiency is associated with a reduced abundance of radixin and Nherf2, two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia. | The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.
Vogl C, Butola T, Haag N, Hausrat TJ, Leitner MG, Moutschen M, Lefèbvre PP, Speckmann C, Garrett L, Becker L, Fuchs H, Hrabe de Angelis M, Nietzsche S, Kessels MM, Oliver D, Kneussel M, Kilimann MW, Strenzke N., Free PMC Article | 07/21/2018 |
| Knockdown of NHERF2 decreased colon cancer progression. NHERF2 deletion attenuated Stat3 activation and CD24 expression in colon cancer cells. | Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24.
Yoshida M, Zhao L, Grigoryan G, Shim H, He P, Yun CC., Free PMC Article | 06/10/2017 |
| NHERF2 is differentially distributed to lipid rafts in brush border membrane fractions of NHE3. | Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3.
Sultan A, Luo M, Yu Q, Riederer B, Xia W, Chen M, Lissner S, Gessner JE, Donowitz M, Yun CC, deJonge H, Lamprecht G, Seidler U., Free PMC Article | 08/16/2014 |
| involvement of NHERF2 in multiple apical regulatory processes and interactions with luminal contents | Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles.
Donowitz M, Singh S, Singh P, Chakraborty M, Chen Y, Murtazina R, Gucek M, Cole RN, Zachos NC, Salahuddin FF, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X., Free PMC Article | 10/15/2011 |
| NHERF2 is necessary for multiple aspects of acute regulation of NHE3 in intact mouse small intestine | NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.
Murtazina R, Kovbasnjuk O, Chen TE, Zachos NC, Chen Y, Kocinsky HS, Hogema BM, Seidler U, de Jonge HR, Donowitz M., Free PMC Article | 09/10/2011 |
| It was concluded that NHERF2 plays important roles in tethering NHE3 to a position near the terminal web and in second messenger inhibition of NHE3 in a signal- and segment-specific fashion. | Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine.
Chen M, Sultan A, Cinar A, Yeruva S, Riederer B, Singh AK, Li J, Bonhagen J, Chen G, Yun C, Donowitz M, Hogema B, de Jonge H, Seidler U., Free PMC Article | 08/13/2011 |
| Lysophosphatidic acid (LPA) is a potent stimulant of NHE3 and fluid absorption in the intestine, signaling through LPA(5). Regulation by LPA(5) depends on its interaction with NHERF2. | Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.
Lin S, Yeruva S, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC., Free PMC Article | 04/12/2010 |
| CFTR-dependent duodenal bicarbonate-ion secretion in mouse models of NHERF-2 loss of function. | Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.
Singh AK, Riederer B, Krabbenhöft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U., Free PMC Article | 01/21/2010 |
| Knockout mice for 3 members of the sodium-hydrogen regulatory factor (NHERF) family of PDZ adaptor proteins, NHERF1 (EBP50), NHERF2 (E3KARP) and NHERF3 (PDZK1), have helped to show that NHERF1 is essential for both normal and mutant CFTR function [review] | Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension.
Seidler U, Singh A, Chen M, Cinar A, Bachmann O, Zheng W, Wang J, Yeruva S, Riederer B. | 01/21/2010 |
| There were no differences in the urinary excretion of protein or low-molecular-weight proteins between wild-type control, NHERF-1 and NHERF-2 deficient mice. | Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice.
Cunningham R, Esmaili A, Brown E, Biswas RS, Murtazina R, Donowitz M, Dijkman HB, van der Vlag J, Hogema BM, De Jonge HR, Shenolikar S, Wade JB, Weinman EJ. | 01/21/2010 |
| NHERF-1 but not NHERF-2 in native intestinal epithelium is involved in the formation of CFTR-containing functional complexes that serve to position CFTR in the crypt apical membrane and to optimize its function as a cAMP- and cGMP-regulated anion channel | Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.
Broere N, Hillesheim J, Tuo B, Jorna H, Houtsmuller AB, Shenolikar S, Weinman EJ, Donowitz M, Seidler U, de Jonge HR, Hogema BM. | 01/21/2010 |
| analysis of NHERF recognition by ERM proteins | Structural basis for NHERF recognition by ERM proteins.
Terawaki S, Maesaki R, Hakoshima T. | 01/21/2010 |
| demonstration of the significance of SGK1 and NHERF2 as TRPV5 modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3 | Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1.
Palmada M, Poppendieck S, Embark HM, van de Graaf SF, Boehmer C, Bindels RJ, Lang F. | 01/21/2010 |
| the function of SIP-1/NHERF2 as an SRY cofactor during testis determination is conserved between human and mouse | NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY.
Thevenet L, Albrecht KH, Malki S, Berta P, Boizet-Bonhoure B, Poulat F. | 01/21/2010 |
| NHERF-2 and mGluR5 exhibit overlapping patterns of expression in mouse brain, where their association prolongs intracellular calcium mobilization by mGluR5 and promotes mGluR5-mediated toxicity. | The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity.
Paquet M, Asay MJ, Fam SR, Inuzuka H, Castleberry AM, Oller H, Smith Y, Yun CC, Traynelis SF, Hall RA., Free PMC Article | 01/21/2010 |