| Our results show that BMP binding is required for TWSG1-mediated inhibition of osteoclast formation and function, and validate the critical functional regions within the TWSG1 protein for these interactions | The Function of Twisted Gastrulation in Regulating Osteoclast Differentiation is Dependent on BMP Binding.
Huntley R, Davydova J, Petryk A, Billington CJ Jr, Jensen ED, Mansky KC, Gopalakrishnan R., Free PMC Article | 06/4/2016 |
| The goal of this study was to examine whether mice carrying a mutation in a gene encoding Twsg1, which is associated with a low penetrance of holoprosencephaly, are sensitized to retinoic acid teratogenesis. | Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice.
Billington CJ Jr, Schmidt B, Marcucio RS, Hallgrimsson B, Gopalakrishnan R, Petryk A., Free PMC Article | 10/3/2015 |
| BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. | BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization.
Forsman CL, Ng BC, Heinze RK, Kuo C, Sergi C, Gopalakrishnan R, Yee D, Graf D, Schwertfeger KL, Petryk A., Free PMC Article | 01/26/2013 |
| Data show that Bmp4, Bmp7, Gremlin and Twisted gastrulation (Twsg1) are all expressed in the thymus and expression was clearly different for each gene investigated. | Compartmentalization of bone morphogenetic proteins and their antagonists in lymphoid progenitors and supporting microenvironments and functional implications.
Passa O, Tsalavos S, Belyaev NN, Petryk A, Potocnik AJ, Graf D., Free PMC Article | 12/17/2011 |
| suggesting that Twsg1 expression in B cells serves to interpret BMP signals on a per-cell basis | Involvement of twisted gastrulation in T cell-independent plasma cell production.
Tsalavos S, Segklia K, Passa O, Petryk A, O'Connor MB, Graf D. | 10/8/2011 |
| These results demonstrate that phenotypic variability in Twsg1-/- mice is associated with differential expression of certain developmentally regulated genes, and that craniofacial defects can be partially rescued by reduced p53 levels. | The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.
Billington CJ Jr, Ng B, Forsman C, Schmidt B, Bagchi A, Symer DE, Schotta G, Gopalakrishnan R, Sarver AL, Petryk A., Free PMC Article | 08/13/2011 |
| TWSG1 overexpression inhibits RANKL-induced osteoclast differentiation | Bone morphogenetic protein 2 signaling in osteoclasts is negatively regulated by the BMP antagonist, twisted gastrulation.
Pham L, Beyer K, Jensen ED, Rodriguez JS, Davydova J, Yamamoto M, Petryk A, Gopalakrishnan R, Mansky KC., Free PMC Article | 06/18/2011 |
| TWSG1 appears to be the main regulator of BMP present in CP. | The expression of twisted gastrulation in postnatal mouse brain and functional implications.
Sun M, Forsman C, Sergi C, Gopalakrishnan R, O'Connor MB, Petryk A., Free PMC Article | 11/27/2010 |
| Cv2 enhances pro-BMP activity of Tsg. | Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.
Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y. | 03/1/2010 |
| A novel and previously uncharacterized role is presented for TWSG1 in inhibiting osteoclastogenesis through regulation of bone morphogenetic proteins activity. | Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signaling.
Sotillo Rodriguez JE, Mansky KC, Jensen ED, Carlson AE, Schwarz T, Pham L, MacKenzie B, Prasad H, Rohrer MD, Petryk A, Gopalakrishnan R., Free PMC Article | 01/21/2010 |
| Twsg1 interferes with BMP-mediated hepcidin expression and may act with GDF15 to dysregulate iron homeostasis | Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.
Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, Lee YT, Goodnough JB, Harandi O, Ganz T, Paulson RF, Miller JL., Free PMC Article | 01/21/2010 |
| Twsg1 limits apoptosis in the distal region of the mandibular arch in mice. | Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice.
MacKenzie B, Wolff R, Lowe N, Billington CJ Jr, Peterson A, Schmidt B, Graf D, Mina M, Gopalakrishnan R, Petryk A., Free PMC Article | 01/21/2010 |
| Development of the vertebral morphogenetic field is reported in the interactions of CV-2 and Twg. | Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation.
Zakin L, Metzinger CA, Chang EY, Coffinier C, De Robertis EM., Free PMC Article | 01/21/2010 |
| The context-dependent functional relationship between Tsg and Cv2 during mouse development, is presented. | Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice.
Ikeya M, Nosaka T, Fukushima K, Kawada M, Furuta Y, Kitamura T, Sasai Y. | 01/21/2010 |
| The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. | The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development.
Graf D, Nethisinghe S, Palmer DB, Fisher AG, Merkenschlager M., Free PMC Article | 01/21/2010 |
| Tsg overexpression inhibits BMP action in stromal and preosteoblastic cells and, accordingly, arrests their differentiation toward the osteoblastic pathway | Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro.
Gazzerro E, Deregowski V, Vaira S, Canalis E. | 01/21/2010 |
| acts as both a BMP-4 agonist in skeletogenesis and a BMP-4 antagonist in T-cell development | Mammalian twisted gastrulation is essential for skeleto-lymphogenesis.
Nosaka T, Morita S, Kitamura H, Nakajima H, Shibata F, Morikawa Y, Kataoka Y, Ebihara Y, Kawashima T, Itoh T, Ozaki K, Senba E, Tsuji K, Makishima F, Yoshida N, Kitamura T., Free PMC Article | 01/21/2010 |
| results suggest that twisted gastrulation and chordin are involved in osteoblast differentiation and mineralization by regulating BMP signaling | Twisted gastrulation and chordin inhibit differentiation and mineralization in MC3T3-E1 osteoblast-like cells.
Petryk A, Shimmi O, Jia X, Carlson AE, Tervonen L, Jarcho MP, O'connor MB, Gopalakrishnan R. | 01/21/2010 |
| endogenous Tsg is required for normal BMP activity in osteoblastic cells in vitro, but it plays a minor role in the regulation of adult bone homeostasis in vivo | Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function.
Gazzerro E, Deregowski V, Stadmeyer L, Gale NW, Economides AN, Canalis E. | 01/21/2010 |
| TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation | Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo.
Schmidl M, Adam N, Surmann-Schmitt C, Hattori T, Stock M, Dietz U, de Crombrugghe B, Pöschl E, von der Mark K. | 01/21/2010 |
| Tsg-/-;Bmp4+/- compound mutants die at birth and display holoprosencephaly, first branchial arch and eye defects | Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development.
Zakin L, De Robertis EM. | 01/21/2010 |