| Expression, Regulation, and Role of an Oligopeptide Transporter: PEPT1 in Tumors. | Expression, Regulation, and Role of an Oligopeptide Transporter: PEPT1 in Tumors.
Wang X, Chen Y, Wang Y, Wang B, Zhang J, Jian X. | 06/11/2022 |
| Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1. | Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1.
Rafiq M, Ernst HA, Aduri NG, Prabhala BK, Tufail S, Rahman M, Bloch MB, Mirza N, Taylor NMI, Boesen T, Gajhede M, Mirza O. | 03/5/2022 |
| PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target. | PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target.
Schniers BK, Rajasekaran D, Korac K, Sniegowski T, Ganapathy V, Bhutia YD., Free PMC Article | 11/27/2021 |
| Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity. | Protonation State of a Histidine Residue in Human Oligopeptide Transporter 1 (hPEPT1) Regulates hPEPT1-Mediated Efflux Activity.
Omori A, Fujisawa Y, Sasaki S, Shimono K, Kikukawa T, Miyauchi S. | 11/27/2021 |
| Epigenetic regulation of intestinal peptide transporter PEPT1 as a potential strategy for colorectal cancer sensitization. | Epigenetic regulation of intestinal peptide transporter PEPT1 as a potential strategy for colorectal cancer sensitization.
Wang Y, Wang J, Yang L, Qiu L, Hua Y, Wu S, Zeng S, Yu L, Zheng X., Free PMC Article | 09/25/2021 |
| Alternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide. | Alternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide.
Kudo M, Kobayashi-Nakamura K, Kitajima N, Tsuji-Naito K. | 08/22/2020 |
| SLC15A1 rs2297322 and rs1289389 polymorphisms were associated with alterations in the risk of dyslipidaemia. | Association of SLC15A1 polymorphisms with susceptibility to dyslipidaemia in a Chinese Han population.
Liu S, Wang C, Chen Y, Peng S, Chen X, Tan Z. | 03/21/2020 |
| PepT1 could serve as a desirable target for oral nanoparticulate drug delivery. | Dipeptide-modified nanoparticles to facilitate oral docetaxel delivery: new insights into PepT1-mediated targeting strategy.
Du Y, Tian C, Wang M, Huang D, Wei W, Liu Y, Li L, Sun B, Kou L, Kan Q, Liu K, Luo C, Sun J, He Z., Free PMC Article | 10/20/2018 |
| REVIEW: summarizes the progress made in the regulation of PepT1 and provides insights into the PepT1's potential in clinical aspects of nutritional and drug therapies | Regulation profile of the intestinal peptide transporter 1 (PepT1).
Wang CY, Liu S, Xie XN, Tan ZR., Free PMC Article | 08/11/2018 |
| Although small intestinal PEPT1 expression tended to be lower in neonates than in older children, this difference is small and tissue distribution is similar. This finding suggests similar oral absorption of PEPT1 substrates across the pediatric age range. | Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants.
Mooij MG, de Koning BE, Lindenbergh-Kortleve DJ, Simons-Oosterhuis Y, van Groen BD, Tibboel D, Samsom JN, de Wildt SN. | 01/27/2018 |
| PEPT1 overexpression is associated with pancreatic cancer. | A new target ligand Ser-Glu for PEPT1-overexpressing cancer imaging.
Dai T, Li N, Zhang L, Zhang Y, Liu Q., Free PMC Article | 09/3/2016 |
| Data (including data from studies in transgenic/knockout mice) suggest human PEPT1 and mouse PepT1 exhibit different affinities for antibiotic cefadroxil; these differences may account for species differences in intestinal absorption of cefadroxil. | Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice.
Hu Y, Smith DE., Free PMC Article | 08/27/2016 |
| Phe-Psi-Ala is a high-affinity, metabolically stable, non-radioactive probe for PEPT1. | Evaluation of a thiodipeptide, L-phenylalanyl-Ψ[CS-N]-L-alanine, as a novel probe for peptide transporter 1.
Arakawa H, Saito S, Kanagawa M, Kamioka H, Yano K, Morimoto K, Ogihara T. | 10/31/2015 |
| miRNA-193a-3p can target colonic PepT1 and reduce intestinal inflammation. | MicroRNA-193a-3p Reduces Intestinal Inflammation in Response to Microbiota via Down-regulation of Colonic PepT1.
Dai X, Chen X, Chen Q, Shi L, Liang H, Zhou Z, Liu Q, Pang W, Hou D, Wang C, Zen K, Yuan Y, Zhang CY, Xia L., Free PMC Article | 10/3/2015 |
| OSR1 has the capacity to downregulate the peptide transporters PEPT1 and PEPT2 by decreasing the carrier protein abundance in the cell membrane | Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.
Warsi J, Elvira B, Bissinger R, Shumilina E, Hosseinzadeh Z, Lang F. | 09/12/2015 |
| The PEPT1 rs2297322 single-nucleotide polymorphism was not associated with inflammatory bowel disease susceptibility in our German cohort. | Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.
Wuensch T, Ullrich S, Schulz S, Chamaillard M, Schaltenberg N, Rath E, Goebel U, Sartor RB, Prager M, Büning C, Bugert P, Witt H, Haller D, Daniel H. | 02/28/2015 |
| Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, could play a crucial role in cell-to-cell communication during colitis | Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, plays an important role in cell-to-cell communication during colitis.
Ayyadurai S, Charania MA, Xiao B, Viennois E, Zhang Y, Merlin D., Free PMC Article | 01/3/2015 |
| The present review summarizes the recent knowledge on the factors modulating PEPT1 expression/function in Caenorhabditis elegans, Danio rerio, Mus musculus and Homo sapiens, with focus on dietary ingredients, transcription factors and modulators.[review] | Transcriptional and functional regulation of the intestinal peptide transporter PEPT1.
Spanier B., Free PMC Article | 11/8/2014 |
| promoter constructs were generated and cotransfected with an Nrf2 expression plasmid | Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon carcinoma cell line Caco-2.
Geillinger KE, Kipp AP, Schink K, Röder PV, Spanier B, Daniel H. | 07/5/2014 |
| JAK3 is a powerful regulator of the peptide transporters PEPT1 and PEPT2. | Effect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2.
Warsi J, Hosseinzadeh Z, Dong L, Pakladok T, Umbach AT, Bhavsar SK, Shumilina E, Lang F. | 06/14/2014 |
| The induction of PEPT1 gene and the suppression of ABCG2 gene expression are among the key molecular mechanisms underlying tumor-specific PpIX accumulation after the administration of ALA in bladder cancer. | Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer.
Hagiya Y, Fukuhara H, Matsumoto K, Endo Y, Nakajima M, Tanaka T, Okura I, Kurabayashi A, Furihata M, Inoue K, Shuin T, Ogura S. | 04/5/2014 |
| These studies unequivocally demonstrate the presence of PEPT1 protein in healthy distal colonic epithelium in mice, rats, and humans and proved that the protein is functional and contributes to electrolyte and water handling in mice. | The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption.
Wuensch T, Schulz S, Ullrich S, Lill N, Stelzl T, Rubio-Aliaga I, Loh G, Chamaillard M, Haller D, Daniel H. | 09/14/2013 |
| PC-3 demonstrates strong expression of PEPT1 and PHT1. | Expression profile and functional activity of peptide transporters in prostate cancer cells.
Tai W, Chen Z, Cheng K., Free PMC Article | 08/31/2013 |
| that Pept1(-/-) mice lack the adaptation of the upper small intestinal mucosa to the trophic effects of the diet | Mice lacking the intestinal peptide transporter display reduced energy intake and a subtle maldigestion/malabsorption that protects them from diet-induced obesity.
Kolodziejczak D, Spanier B, Pais R, Kraiczy J, Stelzl T, Gedrich K, Scherling C, Zietek T, Daniel H. | 07/20/2013 |
| High affinity of NP-647 toward PEPT1 binding site as compared to TRH. | Mechanistic insights into PEPT1-mediated transport of a novel antiepileptic, NP-647.
Khomane KS, Nandekar PP, Wahlang B, Bagul P, Shaikh N, Pawar YB, Meena CL, Sangamwar AT, Jain R, Tikoo K, Bansal AK. | 03/9/2013 |