| SLC14A1 and TGF-beta signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasis. | SLC14A1 and TGF-β signaling: a feedback loop driving EMT and colorectal cancer metachronous liver metastasis.
Zhang Y, Yang Y, Qi X, Cui P, Kang Y, Liu H, Wei Z, Wang H., Free PMC Article | 09/5/2024 |
| Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression. | Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression.
Ma J, Xue K, Jiang Y, Wang X, He D, Guo P., Free PMC Article | 07/23/2024 |
| SLC14A1 is a new biomarker in renal cancer. | SLC14A1 is a new biomarker in renal cancer.
Wan Z, Wang Y, Li C, Zheng D. | 06/29/2023 |
| Study on the role of SLC14A1 gene in biochemical recurrence of prostate cancer. | Study on the role of SLC14A1 gene in biochemical recurrence of prostate cancer.
Ye B, Ding K, Li K, Zhu Q., Free PMC Article | 10/29/2022 |
| A potential link between AQP3 and SLC14A1 gene expression level and clinical parameters of maintenance hemodialysis patients. | A potential link between AQP3 and SLC14A1 gene expression level and clinical parameters of maintenance hemodialysis patients.
Zwiech R, Bruzda-Zwiech A, Balcerczak E, Szczepańska J, Krygier A, Małachowska B, Michałek D, Szmajda-Krygier D., Free PMC Article | 09/3/2022 |
| Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program. | Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program.
Dinardo CL, Oliveira TGM, Kelly S, Ashley-Koch A, Telen M, Schmidt LC, Castilho S, Melo K, Dezan MR, Wheeler MM, Johnsen JM, Nickerson DA, Jain D, Custer B, Pereira AC, Sabino EC, NHLBI Recipient Epidemiology Donor Evaluation Study (REDS-III) International Component-Brazil, the Outcome Modifying Genes in SCD (OMG) study and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program Sickle Cell Disease Working Group. | 07/10/2021 |
| SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma. | SLC14A1 prevents oncometabolite accumulation and recruits HDAC1 to transrepress oncometabolite genes in urothelial carcinoma.
Chan TC, Wu WJ, Li WM, Shiao MS, Shiue YL, Li CF., Free PMC Article | 06/12/2021 |
| Decreased Expression of the Human Urea Transporter SLC14A1 in Bone is Induced by Cytokines and Stimulates Adipogenesis of Mesenchymal Progenitor Cells. | Decreased Expression of the Human Urea Transporter SLC14A1 in Bone is Induced by Cytokines and Stimulates Adipogenesis of Mesenchymal Progenitor Cells.
Komrakova M, Blaschke M, Ponce ML, Klüver A, Köpp R, Hüfner M, Schieker M, Miosge N, Siggelkow H. | 06/5/2021 |
| A novel JK null allele in a Brazilian patient with sickle cell disease (SCD). | A novel JK null allele in a Brazilian patient with sickle cell disease (SCD).
Castilho L, Bub CB, Aravechia MG, Kutner JM, Berlivet I, Férec C, Fichou Y. | 05/30/2020 |
| Study found that UT-B expression is decreased in human melanoma tissue. Its overexpression plays a role in tumor growth regulation of melanoma cell lines and animal transplantation models, and this, combined with findings from UT-B inhibition in bladder cancer, suggests that UT-B may have tumor suppressor functions. | Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, Liu Y, Fu S, Zhang L, Li Y, Meng Y., Free PMC Article | 01/5/2019 |
| The urea transporter subtypes, UT-A1 and UT-B1, were expressed in the skin basal cell layer and exocrine sweat glands. The abundance of UT-A1 and UT-B1 in uremic sweat glands was significantly increased in UP, while the expression of AQP5 was decreased. | The Expression of AQP5 and UTs in the Sweat Glands of Uremic Patients.
Xie L, Jin L, Feng J, Lv J., Free PMC Article | 07/28/2018 |
| In addition to the well known Polynesian Jknull allele, three Jknull alleles were detected including one novel Jknull allele: JKA (130A, 220G). | Molecular genetic analysis of the Jk(a-b-) phenotype in Chinese: A novel silent recessive JK allele.
Zhang A, Chi Q, Lin H, She Y. | 03/25/2017 |
| The Jk(a-b-) phenotype in the Chinese population shows several different molecular mechanisms. A novel missense mutation nt737T>G of JK gene was found as associated with Jk(a-b-) phenotype. | A novel missense mutation nt737T>G of JK gene with Jk(a-b-) phenotype in Chinese blood donors.
Ma L, Liu YC, Zhu SW, Hu WJ, Chen X, Xue M, Zhen L, Wu MH, Liu Y, Sun J. | 01/30/2016 |
| Data indicate that urea transporter UT-A1 successfully trafficking to the apical membrane of the epithelial cells is crucial for the regulation of urea transport. | New advances in urea transporter UT-A1 membrane trafficking.
Chen G., Free PMC Article | 10/24/2015 |
| Results suggested that polymorphism in TERTC/T and SLC14A1C/T confirmed high risk for BC in North Indian population. | Replicative study of GWAS TP63C/T, TERTC/T, and SLC14A1C/T with susceptibility to bladder cancer in North Indians.
Singh V, Jaiswal PK, Mittal RD. | 09/5/2015 |
| Reduction or loss of UT-B expression may be related to the incidence, progression and invasiveness of bladder urothelial carcinoma. | Clinical significance of the reduction of UT-B expression in urothelial carcinoma of the bladder.
Li C, Xue H, Lei Y, Zhu J, Yang B, Gai X. | 08/15/2015 |
| Studies indicate that acid substitution in the urea transporter Slc14A1 UT-B protein determines the erythrocyte Kidd blood group antigen. | Clinical aspects of urea transporters.
Ran J, Wang H, Hu T. | 05/2/2015 |
| Studies indicate that expression of urea transporter UT-B confers high urea permeability to erythrocytes. | Transport characteristics of urea transporter-B.
Yang B. | 05/2/2015 |
| UT-B should be considered as a new member of the water channel family. | Energetic and molecular water permeation mechanisms of the human red blood cell urea transporter B.
Azouzi S, Gueroult M, Ripoche P, Genetet S, Colin Aronovicz Y, Le Van Kim C, Etchebest C, Mouro-Chanteloup I., Free PMC Article | 03/7/2015 |
| High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles. | High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles.
Meyer S, Vollmert C, Trost N, Brönnimann C, Gottschalk J, Buser A, Frey BM, Gassner C. | 02/14/2015 |
| these data confirm the presence of UT-B protein within the human bladder. | Expression and localization of a UT-B urea transporter in the human bladder.
Walpole C, Farrell A, McGrane A, Stewart GS. | 01/3/2015 |
| Novel polymorphisms in exon 9 of the JSLC14A1 gene in Japanese individuals associated with the Jk(a-b-) phenotype. | JK null alleles identified from Japanese individuals with Jk(a−b−) phenotype.
Onodera T, Sasaki K, Tsuneyama H, Isa K, Ogasawara K, Satake M, Tadokoro K, Uchikawa M. | 11/22/2014 |
| Thienoquinoline PU-14 is a selective UT inhibitor and has urea-selective diuretic activity. | A novel small-molecule thienoquinolin urea transporter inhibitor acts as a potential diuretic.
Li F, Lei T, Zhu J, Wang W, Sun Y, Chen J, Dong Z, Zhou H, Yang B. | 01/11/2014 |
| SLC14A1 could be a unique urea transporter in the bladder that has the ability to influence urine concentration and that this mechanism might explain the increased bladder cancer susceptibility associated with rs10775480. | Differential urinary specific gravity as a molecular phenotype of the bladder cancer genetic association in the urea transporter gene, SLC14A1.
Koutros S, Baris D, Fischer A, Tang W, Garcia-Closas M, Karagas MR, Schwenn M, Johnson A, Figueroa J, Waddell R, Prokunina-Olsson L, Rothman N, Silverman DT., Free PMC Article | 12/14/2013 |
| Inhibitor and mutagenesis studies and results of molecular dynamics simulations suggest that NH and HO pass through the three monomeric urea channels in UT-B. | Movement of NH₃ through the human urea transporter B: a new gas channel.
Geyer RR, Musa-Aziz R, Enkavi G, Mahinthichaichan P, Tajkhorshid E, Boron WF., Free PMC Article | 08/31/2013 |