| Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats. | Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats.
Ismail CAN, Suppian R, Ab Aziz CB, Long I. | 10/9/2021 |
| HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage. | HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage.
Formisano L, Laudati G, Guida N, Mascolo L, Serani A, Cuomo O, Cantile M, Boscia F, Molinaro P, Anzilotti S, Pizzorusso V, Di Renzo G, Pignataro G, Annunziato L., Free PMC Article | 03/20/2021 |
| NF-kB signal pathway promoted the expression of DREAM gene. | The function of DREAM gene mediated by NF-kB signal pathway in the pathogenesis of osteosarcoma.
Qian J, Lv M, Zhang W. | 07/6/2019 |
| The KChIP3-TRPV1 interaction reduces the surface localization of TRPV1 and thus alleviates heat hyperalgesia and gait alterations induced by peripheral inflammation | KChIP3 N-Terminal 31-50 Fragment Mediates Its Association with TRPV1 and Alleviates Inflammatory Hyperalgesia in Rats.
Tian NX, Xu Y, Yang JY, Li L, Sun XH, Wang Y, Zhang Y., Free PMC Article | 06/8/2019 |
| DREAM expression and REM sleep deprivation, as well as sleep recovery, are linked which may indicate potential involvement of DREAM in REM sleep-induced changes in gene expression, specifically in nociceptive processing. | REM sleep deprivation induces changes of down regulatory antagonist modulator (DREAM) expression in the ventrobasal thalamic nuclei of sprague-dawley rats.
Siran R, Ahmad AH, Abdul Aziz CB, Ismail Z. | 07/25/2015 |
| This study demonistrared that the expression and function of KCHIP3 channels in neurons of the rat bed nucleus of the stria terminalis. | Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.
Rainnie DG, Hazra R, Dabrowska J, Guo JD, Li CC, Dewitt S, Muly EC., Free PMC Article | 08/30/2014 |
| The expression of calsenilin was found to be increased in brain following experimental ischemic stroke. | Calsenilin contributes to neuronal cell death in ischemic stroke.
Park JS, Manzanero S, Chang JW, Choi Y, Baik SH, Cheng YL, Li YI, Gwon AR, Woo HN, Jang J, Choi IY, Lee JY, Jung YK, Tang SC, Sobey CG, Arumugam TV, Jo DG., Free PMC Article | 02/1/2014 |
| expression of DREAM was increased in the spinal cord after formalin-induced pain; nitric oxide may play an important role in the DREAM pathway modulation of inflammatory pain | Nitric oxide modulated the expression of DREAM/calsenilin/KChIP3 in inflammatory pain of rats.
Jin HB, Yang YL, Song YL, Yang YB, Li YR. | 06/29/2013 |
| This study demonstrated that the KCNIP proteins localize differently when over-expressed in primary cortical neurons. | Subcellular localization and transcription regulatory potency of KCNIP/Calsenilin/DREAM/KChIP proteins in cultured primary cortical neurons do not provide support for their role in CRE-dependent gene expression.
Pruunsild P, Timmusk T. | 11/24/2012 |
| these data suggest an altered expression and function of KChIP3 after streptozotocin induced hyperglycemia that might help explain some pathological alterations in early diabetic retinopathy. | Hyperglycemia induces early upregulation of the calcium sensor KChIP3/DREAM/calsenilin in the rat retina.
Chavira-Suárez E, Sandoval A, Quintero H, Bustamante P, Felix R, Lamas M. | 04/14/2012 |
| In cardiomyocytes, [Ca2+]i-activated calmodulin kinase II (CaMKII) activates downstreamregulatory element (DRE) binding transcription factor DREAM, which consequently suppresses the expression of L-type calcium channel 1C-subunit gene (Cacna1c). | Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation.
Ronkainen JJ, Hänninen SL, Korhonen T, Koivumäki JT, Skoumal R, Rautio S, Ronkainen VP, Tavi P., Free PMC Article | 10/8/2011 |
| Sumoylation regulates the nuclear localization of DREAM in differentiated neurons. | Sumoylation regulates nuclear localization of repressor DREAM.
Palczewska M, Casafont I, Ghimire K, Rojas AM, Valencia A, Lafarga M, Mellström B, Naranjo JR. | 07/23/2011 |
| Data suggest that upregulation of DREAM mRNA and protein expression in the nuclear compartment probably has functional consequences other than just the repression of prodynorphin gene. | Increases in mRNA and DREAM protein expression in the rat spinal cord after formalin induced pain.
Long I, Suppian R, Ismail Z. | 05/21/2011 |
| Induction of KChIP3 and functional changes of voltage-gated KV4 channels in Muller cells could exert a physiological role in the onset of diabetic retinopathy. | Expression and high glucose-mediated regulation of K+ channel interacting protein 3 (KChIP3) and KV4 channels in retinal Müller glial cells.
Chavira-Suárez E, Sandoval A, Felix R, Lamas M. | 03/12/2011 |
| These results suggest the role of DREAM in the dorsal horn in regulation of PPD gene expression by EAS is frequency dependent, & DREAM may exert different roles in different frequency electroacupuncture under physiological & inflammatory conditions. | Distinct responses of DREAM to electroacupuncture stimulation with different frequencies during physiological and inflammatory conditions in rats.
Li Y, Zhang Y, Han JS, Wang Y. | 01/21/2010 |
| These findings support the notion that the NMDA receptor-dependent modulation of DREAM activity could play a role in relevant physiological processes ranging from retinal response to injury to differentiation capacity of retinal progenitor cells. | D-Serine/N-methyl-D-aspartate receptor signaling decreases DNA-binding activity of the transcriptional repressor DREAM in Müller glia from the retina.
Chavira-Suárez E, Ramírez M, Lamas M. | 01/21/2010 |
| DREAM might have other roles in pain modulation in spinal cord in addition to its well-known role as a transcriptional repressor. | Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain.
Zhang Y, Li Y, Yang YR, Zhu HH, Han JS, Wang Y. | 01/21/2010 |
| KChIPs have an essential role in determining both the biophysical and molecular characteristics of Kv4 channels | A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.
Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS. | 01/21/2010 |
| KChIP3 coassociates with Kv4 subunits in hippocampal membranes, confirming that the KChIPs are tightly associated with Kv4 subunits in native brain A-type channel complexes which may play a major role as modulators of somatodendritic excitability. | KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.
Rhodes KJ, Carroll KI, Sung MA, Doliveira LC, Monaghan MM, Burke SL, Strassle BW, Buchwalder L, Menegola M, Cao J, An WF, Trimmer JS., Free PMC Article | 01/21/2010 |
| Mutated form of DREAM unable to bind Ca(2+) interferes with thyroid cell proliferation. | The transcriptional repressor DREAM is involved in thyroid gene expression.
D'Andrea B, Di Palma T, Mascia A, Motti ML, Viglietto G, Nitsch L, Zannini M. | 01/21/2010 |
| DREAM interacts with thyroid-specific transcription factor TTF-1 and regulates the expression of the thyroglobulin (Tg) gene | Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression.
Rivas M, Mellström B, Naranjo JR, Santisteban P. | 01/21/2010 |
| Glutamate caused nuclear export of DREAM in astrocytes, and transfection of astrocytes with a mutant variant of DREAM that constitutively binds DNA inhibited glutamate-induced c-Fos expression. | Glutamate activates c-fos in glial cells via a novel mechanism involving the glutamate receptor subtype mGlu5 and the transcriptional repressor DREAM.
Edling Y, Ingelman-Sundberg M, Simi A. | 01/21/2010 |
| Findings of DREAM expression in the pituitary in a manner specific to pituitary endocrine cell type raises the possibility that this protein may play a role in determining specific pituitary cell function.[DREAM protein] | Cloning and mRNA expression of the Ca2+-binding DREAM protein in the pituitary.
Leclerc GM, Leclerc GJ, Shorte SL, Stephen Frawley L, Boockfor FR. | 01/21/2010 |