| Glucocorticoids inhibited the adrenergic stimulation of Dio2 at the transcriptional level in brown adipocytes. | Effect of glucocorticoids on the activity, expression and proximal promoter of type II deiodinase in rat brown adipocytes.
Martinez-deMena R, Calvo RM, Garcia L, Obregon MJ. | 10/7/2017 |
| This study demonstrated that reduction of the Dio2 mRNA expression in hippocampus of thyroidectomized Wistar rats. | Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism.
da Conceição RR, Laureano-Melo R, Oliveira KC, de Carvalho Melo MC, Kasamatsu TS, de Barros Maciel RM, de Souza JS, Giannocco G. | 12/17/2016 |
| These studies reveal that tissue-specific differences in D2 ubiquitination are an inherent property of the TRH/TSH feedback mechanism | Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine.
Werneck de Castro JP, Fonseca TL, Ueta CB, McAninch EA, Abdalla S, Wittmann G, Lechan RM, Gereben B, Bianco AC., Free PMC Article | 04/11/2015 |
| cold exposure is accompanied by concerted changes in the metabolism of BAT and oxidative and glycolytic skeletal muscles that are paralleled by type 2 deiodinase activation | Type 2 iodothyronine deiodinase is upregulated in rat slow- and fast-twitch skeletal muscle during cold exposure.
Louzada RA, Santos MC, Cavalcanti-de-Albuquerque JP, Rangel IF, Ferreira AC, Galina A, Werneck-de-Castro JP, Carvalho DP. | 02/28/2015 |
| results of the present study hypothesize that progesterone withdrawal may underlie the decrement in D2 expression, with consequent reduction in the peripheral conversion of T4 into T3 leading to a hypothyroid state. | An evidence for the transcriptional regulation of iodothyronine deiodinase 2 by progesterone in ovarectomized rats.
Awad HA, Alrefaie ZA. | 01/3/2015 |
| Data suggest that type 2 deiodinase is induced in inflammation of tanycytes (as in inflammation of periventricular area, arcuate nucleus, and median eminence of hypothalamus); this enzyme induction appears to involve NFkappaB signaling. | NFκB signaling is essential for the lipopolysaccharide-induced increase of type 2 deiodinase in tanycytes.
de Vries EM, Kwakkel J, Eggels L, Kalsbeek A, Barrett P, Fliers E, Boelen A. | 06/21/2014 |
| Data suggest that type 2 deiodinase induction (and kinetics of induction) in animal models of inflammation of leptomeninges, choroid plexus, and brain blood vessels is tissue specific and species specific. | Inflammation-inducible type 2 deiodinase expression in the leptomeninges, choroid plexus, and at brain blood vessels in male rodents.
Wittmann G, Harney JW, Singru PS, Nouriel SS, Reed Larsen P, Lechan RM., Free PMC Article | 06/21/2014 |
| In rat articular cartilage, DIO2 is specifically expressed among deiodinases and dominantly expressed the same as in brown adipose tissue. | Deiodinase 2 upregulation demonstrated in osteoarthritis patients cartilage causes cartilage destruction in tissue-specific transgenic rats.
Nagase H, Nagasawa Y, Tachida Y, Sakakibara S, Okutsu J, Suematsu N, Arita S, Shimada K. | 08/10/2013 |
| Response of pituitary Dio1 and brown adipose tissue Dio2 is blunted in ovariectomized rats. | Blunted response of pituitary type 1 and brown adipose tissue type 2 deiodinases to swimming training in ovariectomized rats.
Ignacio DL, Fortunato RS, Neto RA, da Silva Silvestre DH, Nigro M, Frankenfeld TG, Werneck-de-Castro JP, Carvalho DP. | 03/16/2013 |
| Data indicate that low-iodine diets induces changes in deiodinase activities, especially in the thyroid, to counteract the low T(4) synthesis and secretion, contributing to maintain the local T(3) concentrations in the tissues with D2 activity. | Deiodinase activities in thyroids and tissues of iodine-deficient female rats.
Lavado-Autric R, Calvo RM, de Mena RM, de Escobar GM, Obregon MJ. | 02/23/2013 |
| The effects of androgen deprivation on thyroid homeostasis, reflected in DioI and DioII expression, are reported. | Orchidectomy of middle-aged rats decreases liver deiodinase 1 and pituitary deiodinase 2 activity.
Sosic-Jurjevic B, Filipovic B, Renko K, Ajdzanovic V, Manojlovic-Stojanoski M, Milosevic V, Köhrle J. | 01/5/2013 |
| Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II. | Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II.
Alvarez-Salas E, Aceves C, Anguiano B, Uribe RM, García-Luna C, Sánchez E, de Gortari P. | 10/6/2012 |
| Results indicate that, beside activation of CREB, epigenetic factors such as histone modifications also play an important role in regulating Dio2 transcription. | Histone modifications on the adrenergic induction of type II deiodinase in rat pinealocytes.
Chik CL, Price DM, Ho AK. | 03/3/2012 |
| Type 1 and type 2 deiodinase may have distinct functions in white adipose tissue, regulating lipogenesis and lipolysis. | Presence and regulation of D1 and D2 deiodinases in rat white adipose tissue.
Calvo RM, Obregon MJ. | 11/12/2011 |
| T3 increases the adrenergic stimulation of UCP1 and D2 expression mostly via the TRbeta1 isoform, and in brown adipocytes, D2 is protected from degradation by the action of T3 on TRbeta1. | The T3 receptor beta1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes.
Martinez de Mena R, Scanlan TS, Obregon MJ. | 11/6/2010 |
| In addition to TSH, other factors derived from the pars tuberalis may contribute to LPS-induced D2 activation in tanycytes. | Contribution of TNF-alpha and nuclear factor-kappaB signaling to type 2 iodothyronine deiodinase activation in the mediobasal hypothalamus after lipopolysaccharide administration.
Sánchez E, Singru PS, Wittmann G, Nouriel SS, Barrett P, Fekete C, Lechan RM., Free PMC Article | 09/13/2010 |
| The results demonstrate that decreased liver D1 and BAT D2 might be involved in the decreased T(4)-to-T(3) conversion detected after an exercise session on the treadmill. | The effect of acute exercise session on thyroid hormone economy in rats.
Fortunato RS, Ignácio DL, Padron AS, Peçanha R, Marassi MP, Rosenthal D, Werneck-de-Castro JP, Carvalho DP. | 01/21/2010 |
| Induction of type 2 iodothyronine deiodinase in the mediobasal hypothalamus by bacterial lipopolysaccharide. | Induction of type 2 iodothyronine deiodinase in the mediobasal hypothalamus by bacterial lipopolysaccharide: role of corticosterone.
Sánchez E, Singru PS, Fekete C, Lechan RM., Free PMC Article | 01/21/2010 |
| The effect of neonatal thyroxine treatment on body weight, fat proportion, serum leptin, and thyroid function of 60-day-old rats, is evaluated. | Thyroid function and body weight programming by neonatal hyperthyroidism in rats - the role of leptin and deiodinase activities.
Moura EG, Santos RS, Lisboa PC, Alves SB, Bonomo IT, Fagundes AT, Oliveira E, Passos MC. | 01/21/2010 |
| Correlation between relative mRNA levels of WSB-1 and USP-33 in numerous tissues that do not express type 2 deiodinase(D2) suggests that these ubiquitin-related enzymes share additional substrates besides D2. | Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
Fekete C, Freitas BC, Zeöld A, Wittmann G, Kádár A, Liposits Z, Christoffolete MA, Singru P, Lechan RM, Bianco AC, Gereben B. | 01/21/2010 |
| Hypoxia leads to stabilization of D2 by slowing its degradation by the proteasome pathway. | Hypoxia stabilizes type 2 deiodinase activity in rat astrocytes.
Lamirand A, Mercier G, Ramaugé M, Pierre M, Courtin F. | 01/21/2010 |
| Data show that suppression of deiodinase type II (DII) by iopanoic acid during fasting prevented elevated DII activity and blunted the decline in hypothalamic thyrotropin releasing hormone mRNA levels. | Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting.
Coppola A, Hughes J, Esposito E, Schiavo L, Meli R, Diano S. | 01/21/2010 |
| data do not support that thyroxine-binding protein p29 has a functional relationship with D2 | Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins.
Montero-Pedrazuela A, Bernal J, Guadaño-Ferraz A. | 01/21/2010 |
| Triiodothyronine is required for the stimulation of type II 5'-deiodinase mRNA in rat brown adipocytes. | Triiodothyronine is required for the stimulation of type II 5'-deiodinase mRNA in rat brown adipocytes.
Martinez-deMena R, Hernández A, Obregón MJ. | 01/21/2010 |
| the suprachiasmatic nuclei separately stimulates D2 activity as well as the hypothalamo-pituitary-thyroid axis | Daily variations in type II iodothyronine deiodinase activity in the rat brain as controlled by the biological clock.
Kalsbeek A, Buijs RM, van Schaik R, Kaptein E, Visser TJ, Doulabi BZ, Fliers E. | 01/21/2010 |