| Hyperglycemia impairs EAAT2 glutamate transporter trafficking and glutamate clearance in islets of Langerhans: implications for type 2 diabetes pathogenesis and treatment. | Hyperglycemia impairs EAAT2 glutamate transporter trafficking and glutamate clearance in islets of Langerhans: implications for type 2 diabetes pathogenesis and treatment.
Galli A, Moretti S, Dule N, Di Cairano ES, Castagna M, Marciani P, Battaglia C, Bertuzzi F, Fiorina P, Pastore I, La Rosa S, Davalli A, Folli F, Perego C., | 06/30/2024 |
| Leat-associated seizures the possible role of EAAT2, pyruvate carboxylase and glutamine synthetase. | Leat-associated seizures the possible role of EAAT2, pyruvate carboxylase and glutamine synthetase.
Buccoliero AM, Caporalini C, Moscardi S, Cetica V, Mei D, Conti V, Nozzoli F, Bonaudo C, Battista F, Giordano F, Mura R, Spacca B, Mussa F, D'Onofrio V, Guerrini R, Genitori L, Scagnet M. | 01/17/2024 |
| The Regulation of GLT-1 Degradation Pathway by SIRT4. | The Regulation of GLT-1 Degradation Pathway by SIRT4.
Yeşilören E, Yalcin GD. | 07/21/2023 |
| The role of excitatory amino acid transporter 2 (EAAT2) in epilepsy and other neurological disorders. | The role of excitatory amino acid transporter 2 (EAAT2) in epilepsy and other neurological disorders.
Alijanpour S, Miryounesi M, Ghafouri-Fard S. | 01/21/2023 |
| Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2. | Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2.
Kato T, Kusakizako T, Jin C, Zhou X, Ohgaki R, Quan L, Xu M, Okuda S, Kobayashi K, Yamashita K, Nishizawa T, Kanai Y, Nureki O., Free PMC Article | 08/20/2022 |
| PKCalpha phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice. | PKCα phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice.
Wang Y, Du J, Lu S, Li X, Chen Y, Yuan C, Hou ST, Wang Y., Free PMC Article | 07/16/2022 |
| Mutations associated with epileptic encephalopathy modify EAAT2 anion channel function. | Mutations associated with epileptic encephalopathy modify EAAT2 anion channel function.
Kovermann P, Kolobkova Y, Franzen A, Fahlke C. | 06/18/2022 |
| Polymorphism of rs12294045 in EAAT2 gene is potentially associated with schizophrenia in Chinese Han population. | Polymorphism of rs12294045 in EAAT2 gene is potentially associated with schizophrenia in Chinese Han population.
Wang L, Ma T, Qiao D, Cui K, Bi X, Han C, Yang L, Sun M, Liu L., Free PMC Article | 04/23/2022 |
| Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity. | Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity.
Pajarillo E, Digman A, Nyarko-Danquah I, Son DS, Soliman KFA, Aschner M, Lee E., Free PMC Article | 02/19/2022 |
| Endocytosis of the glutamate transporter 1 is regulated by laforin and malin: Implications in Lafora disease. | Endocytosis of the glutamate transporter 1 is regulated by laforin and malin: Implications in Lafora disease.
Perez-Jimenez E, Viana R, Muñoz-Ballester C, Vendrell-Tornero C, Moll-Diaz R, Garcia-Gimeno MA, Sanz P., Free PMC Article | 02/12/2022 |
| Conformationally Sensitive Proximity Between the TM3-4 Loop and Hairpin Loop 2 of the Glutamate Transporter EAAT2 Revealed by Paired-Cysteine Mutagenesis. | Conformationally Sensitive Proximity Between the TM3-4 Loop and Hairpin Loop 2 of the Glutamate Transporter EAAT2 Revealed by Paired-Cysteine Mutagenesis.
Wang J, Qu S. | 08/7/2021 |
| Glutamate Transporter 1 expression in human glioblastomas. | Glutamate Transporter 1 expression in human glioblastomas.
Donmez Yalcin G, Oktay E, Yalcin A, Diniz G, Kahraman DS, Senoglu M. | 07/24/2021 |
| Serum expression of EAAT2 and ADORA2A in patients with different degrees of Alzheimer's disease. | Serum expression of EAAT2 and ADORA2A in patients with different degrees of Alzheimer's disease.
Meng SX, Wang B, Li WT. | 07/3/2021 |
| Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China. | Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China.
Gao T, Wu J, Zheng R, Fang Y, Jin CY, Ruan Y, Cao J, Tian J, Pu JL, Zhang BR., Free PMC Article | 07/3/2021 |
| Positive allosteric activation of glial EAAT-2 transporter protein: A novel strategy for Alzheimer's disease. | Positive allosteric activation of glial EAAT-2 transporter protein: A novel strategy for Alzheimer's disease.
Manisha C, Selvaraj A, Jubie S, Moola Joghee Nanjan C, Moola Joghee N, Clement JP, Justin A. | 06/12/2021 |
| The investigation of glutamate transporter 1 (GLT-1) degradation pathway in glioblastoma cells. | The investigation of glutamate transporter 1 (GLT-1) degradation pathway in glioblastoma cells.
Dagdelen DN, Akkulak A, Donmez Yalcin G. | 06/12/2021 |
| Excitatory amino acid transporter (EAAT)1 and EAAT2 mRNA levels are altered in the prefrontal cortex of subjects with schizophrenia. | Excitatory amino acid transporter (EAAT)1 and EAAT2 mRNA levels are altered in the prefrontal cortex of subjects with schizophrenia.
Parkin GM, Gibbons A, Udawela M, Dean B. | 06/12/2021 |
| An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates. | An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates.
Kolen B, Kortzak D, Franzen A, Fahlke C., Free PMC Article | 04/3/2021 |
| A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2). | A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2).
Damm-Ganamet KL, Rives ML, Wickenden AD, McAllister HM, Mirzadegan T., Free PMC Article | 12/12/2020 |
| Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer. | Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.
Bacci M, Lorito N, Ippolito L, Ramazzotti M, Luti S, Romagnoli S, Parri M, Bianchini F, Cappellesso F, Virga F, Gao Q, Simões BM, Marangoni E, Martin LA, Comito G, Ferracin M, Giannoni E, Mazzone M, Chiarugi P, Morandi A., Free PMC Article | 08/29/2020 |
| In schizophrenic patients, EAAT2 G carriers had poorer white matter integrity than EAAT2 T/T subjects. G carriers also showed worse working memory performance. | Genetic variability of glutamate reuptake: Effect on white matter integrity and working memory in schizophrenia.
Mazza E, Spangaro M, Poletti S, Cavallaro R, Benedetti F. | 08/1/2020 |
| This comprehensive review will discuss the regulatory mechanisms of GLAST/GLT-1, their association with neurological disorders, and the pharmacological agents which mediate their expression and function-{REVIEW} | The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics.
Pajarillo E, Rizor A, Lee J, Aschner M, Lee E., Free PMC Article | 07/18/2020 |
| a tight spatial and functional relationship between the DAT/GLT-1 transporters and the Kv7.2/7.3 potassium channel that immediately readjusts the membrane potential of the neuron, probably to limit the neurotransmitter-mediated neuronal depolarization | Identification of potassium channel proteins Kv7.2/7.3 as common partners of the dopamine and glutamate transporters DAT and GLT-1.
Bartolomé-Martín D, Ibáñez I, Piniella D, Martínez-Blanco E, Pelaz SG, Zafra F. | 07/18/2020 |
| in addition to astrocytic EAAT2, neuronal EAAT2 plays a role in hippocampus-dependent memory. the gene expression profiles associated with astrocytic and neuronal EAAT2 deletion are different, with the former associated with inflammation and synaptic function similar to changes observed in human Alzheimer's disease and gene expression changes associated with inflammation similar to the aging human brain. | Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures.
Sharma A, Kazim SF, Larson CS, Ramakrishnan A, Gray JD, McEwen BS, Rosenberg PA, Shen L, Pereira AC., Free PMC Article | 04/11/2020 |
| A recurrent Leu85Pro SLC1A2 variant causes a severe, early onset developmental and epileptic encephalopathy. | Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism.
Stergachis AB, Pujol-Giménez J, Gyimesi G, Fuster D, Albano G, Troxler M, Picker J, Rosenberg PA, Bergin A, Peters J, El Achkar CM, Harini C, Manzi S, Rotenberg A, Hediger MA, Rodan LH., Free PMC Article | 04/4/2020 |