| WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc. | WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc.
Jiang L, Qi X, Lai M, Zhou J, Yuan M, You J, Liu Q, Pan J, Zhao L, Ying M, Ji J, Li K, Zhang Y, Pan W, He Q, Yang B, Cao J., | 10/30/2024 |
| The USP46 complex deubiquitylates LRP6 to promote Wnt/beta-catenin signaling. | The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E., Free PMC Article | 11/6/2023 |
| Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1-mediated glycolysis. | Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1-mediated glycolysis.
Ke L, Jia Z, Gao W, Luo L. | 01/7/2023 |
| MiR-27a-3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma. | MiR-27a-3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma.
Wen M, Xu H, Peng H, Sheng Y, Yang W, Yan J. | 07/23/2022 |
| Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1. | Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1.
Qiu Y, Huang D, Sheng Y, Huang J, Li N, Zhang S, Hong Z, Yin X, Yan J. | 10/9/2021 |
| USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway. | USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway.
Wang W, Chen M, Xu H, Lv D, Zhou S, Yang H., Free PMC Article | 05/15/2021 |
| Data indicate a mechanism of USP46 regulation in renal cell carcinoma (RCC), and that USP46 is a tumor suppressor in RCC via proto-oncogene protein Akt (AKT) signaling pathway inactivation. | Ubiquitin-specific peptidase 46 (USP46) suppresses renal cell carcinoma tumorigenesis through AKT pathway inactivation.
Gui D, Peng W, Jiang W, Huang G, Liu G, Ye Z, Wang Y, Xu Z, Fu J, Luo S, Zhao Y. | 06/27/2020 |
| The deubiquitinase USP46 is essential for proliferation and tumor growth of HPV-transformed cancers. | The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers.
Kiran S, Dar A, Singh SK, Lee KY, Dutta A., Free PMC Article | 05/18/2019 |
| Results suggest role for USP46/USP12 in Epstein-Barr virus induced growth transformation. | The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth.
Ohashi M, Holthaus AM, Calderwood MA, Lai CY, Krastins B, Sarracino D, Johannsen E., Free PMC Article | 04/2/2016 |
| USP46-mediated stabilization of PHLPP and the subsequent inhibition of Akt. | The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer.
Li X, Stevens PD, Yang H, Gulhati P, Wang W, Evers BM, Gao T., Free PMC Article | 06/8/2013 |
| results suggest that the USP46 gene might play a role in the pathophysiology of major depressive disorder in the Japanese population. | Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population.
Fukuo Y, Kishi T, Kushima I, Yoshimura R, Okochi T, Kitajima T, Matsunaga S, Kawashima K, Umene-Nakano W, Naitoh H, Inada T, Nakamura J, Ozaki N, Iwata N. | 11/12/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population.
Kushima I, Aleksic B, Ito Y, Nakamura Y, Nakamura K, Mori N, Kikuchi M, Inada T, Kunugi H, Nanko S, Kato T, Yoshikawa T, Ujike H, Suzuki M, Iwata N, Ozaki N, Kushima I, Aleksic B, Ito Y, Nakamura Y, Nakamura K, Mori N, Kikuchi M, Inada T, Kunugi H, Nanko S, Kato T, Yoshikawa T, Ujike H, Suzuki M, Iwata N, Ozaki N. | 12/5/2010 |
| These data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46. | Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population.
Kushima I, Aleksic B, Ito Y, Nakamura Y, Nakamura K, Mori N, Kikuchi M, Inada T, Kunugi H, Nanko S, Kato T, Yoshikawa T, Ujike H, Suzuki M, Iwata N, Ozaki N, Kushima I, Aleksic B, Ito Y, Nakamura Y, Nakamura K, Mori N, Kikuchi M, Inada T, Kunugi H, Nanko S, Kato T, Yoshikawa T, Ujike H, Suzuki M, Iwata N, Ozaki N. | 10/4/2010 |
| two novel multisubunit deubiquitinating enzyme complexes containing USP12 and USP46, respectively. Both complexes contain the UAF1 protein as a bona fide subunit. Interestingly, UAF1 | UAF1 is a subunit of multiple deubiquitinating enzyme complexes.
Cohn MA, Kee Y, Haas W, Gygi SP, D'Andrea AD., Free PMC Article | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study of biochemical traits in Korcula Island, Croatia.
Zemunik T, Boban M, Lauc G, Janković S, Rotim K, Vatavuk Z, Bencić G, Dogas Z, Boraska V, Torlak V, Susac J, Zobić I, Rudan D, Pulanić D, Modun D, Mudnić I, Gunjaca G, Budimir D, Hayward C, Vitart V, Wright AF, Campbell H, Rudan I., Free PMC Article | 03/25/2009 |