| SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination and degradation of HBx in hepatocellular carcinoma. | SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination and degradation of HBx in hepatocellular carcinoma.
Hu Q, Liu Z, Liu Y, Qiu J, Zhang X, Sun J, Zhang B, Shi H., Free PMC Article | 10/28/2024 |
| SIAH2-Mediated Degradation of ACSL4 Inhibits the Anti-Tumor Activity of CD8+ T Cells in Hepatocellular Carcinoma. | SIAH2-Mediated Degradation of ACSL4 Inhibits the Anti-Tumor Activity of CD8+ T Cells in Hepatocellular Carcinoma.
Shu F, Shi Y, Shan X, Zha W, Fan R, Xue W. | 06/14/2024 |
| SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination. | SIAH2 regulates DNA end resection and replication fork recovery by promoting CtIP ubiquitination.
Jeong SY, Hariharasudhan G, Kim MJ, Lim JY, Jung SM, Choi EJ, Chang IY, Kee Y, You HJ, Lee JH., Free PMC Article | 10/22/2022 |
| Decreased Expression of Programmed Death Ligand-L1 by Seven in Absentia Homolog 2 in Cholangiocarcinoma Enhances T-Cell-Mediated Antitumor Activity. | Decreased Expression of Programmed Death Ligand-L1 by Seven in Absentia Homolog 2 in Cholangiocarcinoma Enhances T-Cell-Mediated Antitumor Activity.
Zheng H, Zheng WJ, Wang ZG, Tao YP, Huang ZP, Yang L, Ouyang L, Duan ZQ, Zhang YN, Chen BN, Xiang DM, Jin G, Fang L, Zhou F, Liang B., Free PMC Article | 03/19/2022 |
| The role of Siah2 in tumorigenesis and cancer therapy. | The role of Siah2 in tumorigenesis and cancer therapy.
Li K, Li J, Ye M, Jin X. | 12/11/2021 |
| Helicobacter pylori-induced gastric cancer is orchestrated by MRCKbeta-mediated Siah2 phosphorylation. | Helicobacter pylori-induced gastric cancer is orchestrated by MRCKβ-mediated Siah2 phosphorylation.
Dixit P, Kokate SB, Poirah I, Chakraborty D, Smoot DT, Ashktorab H, Rout N, Singh SP, Bhattacharyya A., Free PMC Article | 09/4/2021 |
| Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy. | Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy.
Ong T, Trivedi N, Wakefield R, Frase S, Solecki DJ., Free PMC Article | 11/28/2020 |
| SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism. | SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism.
Chillappagari S, Belapurkar R, Möller A, Molenda N, Kracht M, Rohrbach S, Schmitz ML., Free PMC Article | 11/21/2020 |
| Low SIAH2 and FOXP3 expression is identified in immune responsive human melanoma tumors. | Siah2 control of T-regulatory cells limits anti-tumor immunity.
Scortegagna M, Hockemeyer K, Dolgalev I, Poźniak J, Rambow F, Li Y, Feng Y, Tinoco R, Otero DC, Zhang T, Brown K, Bosenberg M, Bradley LM, Marine JC, Aifantis I, Ronai ZA., Free PMC Article | 04/25/2020 |
| Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells | Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.
Kokate SB, Dixit P, Poirah I, Roy AD, Chakraborty D, Rout N, Singh SP, Ashktorab H, Smoot DT, Bhattacharyya A. | 05/4/2019 |
| Acetylation-mediated Siah2 stabilization enhances PHD3 degradation in Helicobacter pylori-infected gastric epithelial cancer cells. | Acetylation-mediated Siah2 stabilization enhances PHD3 degradation in Helicobacter pylori-infected gastric epithelial cancer cells.
Kokate SB, Dixit P, Das L, Rath S, Roy AD, Poirah I, Chakraborty D, Rout N, Singh SP, Bhattacharyya A. | 04/6/2019 |
| DHX15 regulates androgen receptor (AR) activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent of its ATPase activity promoting prostate cancer progression. | DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor.
Jing Y, Nguyen MM, Wang D, Pascal LE, Guo W, Xu Y, Ai J, Deng FM, Masoodi KZ, Yu X, Zhang J, Nelson JB, Xia S, Wang Z., Free PMC Article | 10/13/2018 |
| the Siah2-PHD3- HIF-1alpha-VEGF axis is an important hypoxic signaling pathway in a leukemic microenvironment. | Inhibition of Siah2 Ubiquitin Ligase by Vitamin K3 Attenuates Chronic Myeloid Leukemia Chemo-Resistance in Hypoxic Microenvironment.
Huang J, Lu Z, Xiao Y, He B, Pan C, Zhou X, Xu N, Liu X., Free PMC Article | 08/18/2018 |
| Based on the proposition that NS5 utilizes SIAH2-mediated proteasomal degradation of STAT2, an in-silico study was carried out to characterize the protein-protein interactions between NS5, SIAH2 and STAT2 proteins. | Structural analysis and insight into Zika virus NS5 mediated interferon inhibition.
Dar HA, Zaheer T, Paracha RZ, Ali A. | 03/10/2018 |
| The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways. | The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear.
Zhang Q, Wang Z, Hou F, Harding R, Huang X, Dong A, Walker JR, Tong Y. | 11/4/2017 |
| Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt-induced Axin degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin through interacting with a VxP motif in the GSK3-binding domain of Axin, and this function of SIAH is counteracted by GSK3 binding to Axin. | The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.
Ji L, Jiang B, Jiang X, Charlat O, Chen A, Mickanin C, Bauer A, Xu W, Yan X, Cong F., Free PMC Article | 09/23/2017 |
| SIAH2 regulates CHK2 basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells. | CHK2 stability is regulated by the E3 ubiquitin ligase SIAH2.
García-Limones C, Lara-Chica M, Jiménez-Jiménez C, Pérez M, Moreno P, Muñoz E, Calzado MA. | 09/2/2017 |
| study revealed an interesting mutual regulation between Plk3 and SIAH2 and uncovered a regulatory network that functions to fine-tune the cellular hypoxic response. | Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel.
Li C, Park S, Zhang X, Dai W, Xu D., Free PMC Article | 07/15/2017 |
| ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2 | ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2.
Das L, Kokate SB, Rath S, Rout N, Singh SP, Crowe SE, Mukhopadhyay AK, Bhattacharyya A., Free PMC Article | 05/20/2017 |
| Manipulation of SIAH2 expression led to a 'cross-talk' of the ERK and PI3K pathway. | Overexpression of seven in absentia homolog 2 protein in human breast cancer tissues is associated with the promotion of tumor cell malignant behavior in in vitro.
Sun J, Zhang X, Han Y, Zhen J, Meng Y, Song M. | 03/11/2017 |
| Siah-2 expression was observed in 29.3% of oral squamous cell carcinoma. Siah-2 was located in the cytoplasm and cell membranes. | Siah-1 is associated with expression of hypoxia-inducible factor-1α in oral squamous cell carcinoma.
Aga M, Kondo S, Wakisaka N, Moriyama-Kita M, Endo K, Nakanishi Y, Murono S, Sugimoto H, Ueno T, Yoshizaki T. | 03/11/2017 |
| SIAH2 is associated with a tumor promoting role in breast cancer. | SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.
Adam MG, Matt S, Christian S, Hess-Stumpp H, Haegebarth A, Hofmann TG, Algire C., Free PMC Article | 10/22/2016 |
| Overexpression of Siah2 Is Associated With Epithelial Ovarian Carcinoma | Overexpression of Siah2 Is Associated With Poor Prognosis in Patients With Epithelial Ovarian Carcinoma.
Gao Y, Liu Y, Meng F, Shang P, Wang S, Zhang Y, Sun Y, Wang Y, Wang J, Chen X. | 10/8/2016 |
| Our results suggest that SIAH2 regulates multi processes in T-cell acute lymphoblastic leukemia | The expression and function of E3 ligase SIAH2 in acute T lymphoblastic leukemia.
Chen H, Wang N, Yang G, Guo Y, Shen Y, Wang X, Zhang P, Xu Y. | 07/30/2016 |
| The expression of SIAH2 is increased in human lung cancer. | The Expression of the Ubiquitin Ligase SIAH2 (Seven In Absentia Homolog 2) Is Increased in Human Lung Cancer.
Moreno P, Lara-Chica M, Soler-Torronteras R, Caro T, Medina M, Álvarez A, Salvatierra Á, Muñoz E, Calzado MA., Free PMC Article | 06/28/2016 |