| Taken together, DEHP-disturbed HPT axis and induced 5alpha-Reductase 2 contribute to the reduction of serum testosterone level. The activated ERK pathway is required to modulate expressions of 5alpha-Reductase 2 and SRB1. | Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic-pituitary-testis axis and ERK-mediated 5α-Reductase 2.
Ha M, Guan X, Wei L, Li P, Yang M, Liu C. | 03/24/2018 |
| Results suggest that in the acute phase after spinal cord injury, the increased expression of 18kDa translocator protein and 5alpha-reductase may represent a protective endogenous response against tissue injury. | Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5α-reductase in the dorsal spinal cord of animals with neuropathic pain: Effects of progesterone administration.
Coronel MF, Sánchez Granel ML, Raggio MC, Adler NS, De Nicola AF, Labombarda F, González SL. | 06/10/2017 |
| findings show that, in the adult brain, 5alphaR2 is distributed in critical regions for behavioral regulation, suggesting that the functional role of this isoform is present throughout the entire lifespan of the individual | Regional distribution of 5α-reductase type 2 in the adult rat brain: an immunohistochemical analysis.
Castelli MP, Casti A, Casu A, Frau R, Bortolato M, Spiga S, Ennas MG., Free PMC Article | 03/29/2014 |
| Low Srd5a2 expression is associated with benign prostatic hypertrophy. | Bisphenol A exposure during adulthood alters expression of aromatase and 5α-reductase isozymes in rat prostate.
Castro B, Sánchez P, Torres JM, Preda O, del Moral RG, Ortega E., Free PMC Article | 08/31/2013 |
| Changes in the expression of steroid 5-alpha reductase isoenzymes in the prostate in response to environmental stress. | Expression of steroid 5α-reductase isozymes in prostate of adult rats after environmental stress.
Sánchez P, Torres JM, Castro B, Olmo A, del Moral RG, Ortega E. | 03/2/2013 |
| Tesosterone concentrations during postnatal sexual differentiation of the rat central nervous system, among other sex-dependent factors, influence brain levels of 5alpha-Reductase isozymes in adulthood | Steroid 5α-reductase in adult rat brain after neonatal testosterone administration.
Sánchez P, Torres JM, del Moral RG, de Dios Luna J, Ortega E. | 04/28/2012 |
| The SRD5A2 mRNA expression in normal rat is 4-fold higher than human prostatic tissue. | Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers.
Xu Y, Dalrymple SL, Becker RE, Denmeade SR, Isaacs JT. | 01/21/2010 |
| 5 alpha-R2 labeling was observed in dorsal (DH) and ventral horns of gray matter (Gm). and 60% of 5 alpha-R2 immunostaining colocalized with oligodendrocyte, 25% with neuron, and 15% with astrocyte markers. | Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord.
Patte-Mensah C, Penning TM, Mensah-Nyagan AG. | 01/21/2010 |
| A method for the quantitation of mRNA levels of Srd5a2 isoenzymes has been developed. | Quantitation of mRNA levels of steroid 5alpha-reductase isozymes: a novel method that combines quantitative RT-PCR and capillary electrophoresis.
Torres JM, Ortega E. | 01/21/2010 |
| 5-alpha-reductase type 2 is confined to motoneuronal cells of anterior horns of rat spinal cord, cells that also are known to express high levels of androgen receptor. | Androgen 5-alpha-reductase type 2 is highly expressed and active in rat spinal cord motor neurones.
Pozzi P, Bendotti C, Simeoni S, Piccioni F, Guerini V, Marron TU, Martini L, Poletti A. | 01/21/2010 |
| regulatory elements and the minimal promoter were mapped to the 485-bp region upstream of the start codon | Cloning and characterization of the 5alpha-reductase type 2 promoter in the rat epididymis.
Seenundun S, Robaire B. | 01/21/2010 |
| A high-dietary fat and caloric intake upregulates prostate 5alpha-reductase-2 gene expression, and stimulates prostate growth in neonatal, but not adult r | Regulation of prostate 5alpha-reductase-2 gene expression and prostate weight by dietary fat and caloric intake in the rat.
Cai LQ, Imperato-McGinley J, Zhu YS. | 01/21/2010 |
| great sexual dimorphism in the central nervous system (CNS) with respect to both 5alpha-reductase isozymes, and suggest a crucial role of dihydrotestosterone in the sexual dimorphism of the CNS in the female | Steroid 5alpha-reductase isozymes in the adult female rat brain: central role of dihydrotestosterone.
Torres JM, Ortega E. | 01/21/2010 |