| eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1. | eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.
Li Q, Xiao M, Shi Y, Hu J, Bi T, Wang C, Yan L, Li X., Free PMC Article | 10/16/2021 |
| The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma. | The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma.
Muys BR, Anastasakis DG, Claypool D, Pongor L, Li XL, Grammatikakis I, Liu M, Wang X, Prasanth KV, Aladjem MI, Lal A, Hafner M., Free PMC Article | 08/7/2021 |
| Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. | Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
Bieging-Rolett KT, Kaiser AM, Morgens DW, Boutelle AM, Seoane JA, Van Nostrand EL, Zhu C, Houlihan SL, Mello SS, Yee BA, McClendon J, Pierce SE, Winters IP, Wang M, Connolly AJ, Lowe SW, Curtis C, Yeo GW, Winslow MM, Bassik MC, Attardi LD., Free PMC Article | 01/9/2021 |
| WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA. | WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms.
Lee HC, Jung SH, Hwang HJ, Kang D, De S, Dudekula DB, Martindale JL, Park B, Park SK, Lee EK, Lee JH, Jeong S, Han K, Park HJ, Ko YG, Gorospe M, Lee JS., Free PMC Article | 11/11/2017 |
| we propose that Wig1, a key p53 downstream molecule in HD condition, play an important role in stabilizing mutant Htt mRNA and thereby accelerating HD pathology in the mHtt-p53-Wig1 positive feedback manner | Allele-specific regulation of mutant Huntingtin by Wig1, a downstream target of p53.
Kim SH, Shahani N, Bae BI, Sbodio JI, Chung Y, Nakaso K, Paul BD, Sawa A., Free PMC Article | 07/15/2017 |
| expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma | Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma.
Xu LD, Muller S, Thoppe SR, Hellborg F, Kanter L, Lerner M, Zheng B, Lagercrantz SB, Grandér D, Wallin KL, Wiman KG, Larsson C, Andersson S., Free PMC Article | 07/25/2015 |
| Results suggest a role of Wig-1 as a survival factor that directs the p53 stress response toward cell cycle arrest rather than apoptosis through the regulation of FAS and 14-3-3sigma mRNA levels. | Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ.
Bersani C, Xu LD, Vilborg A, Lui WO, Wiman KG., Free PMC Article | 04/18/2015 |
| PSF and MATR3 are cellular host factors that bind viral RNA and promote Rev activity. | HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3.
Kula A, Gharu L, Marcello A. | 03/9/2013 |
| The data indicated a novel role for Wig1 in RNA-induced silencing complex target accessibility, which is a key step in RNA-mediated gene silencing. Fine tuning of p21 levels by Wig1 was essential for the prevention of cellular senescence. | Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.
Kim BC, Lee HC, Lee JJ, Choi CM, Kim DK, Lee JC, Ko YG, Lee JS., Free PMC Article | 02/9/2013 |
| Wig-1 knockdown causes a dramatic inhibition of N-Myc expression and triggers differentiation in neuroblastoma cells carrying amplified N-Myc. | Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth.
Vilborg A, Bersani C, Wickström M, Segerström L, Kogner P, Wiman KG., Free PMC Article | 07/28/2012 |
| WIG-1 might be involved in the zinc-induced cell cycle arrest and apoptosis of human esophageal squamous cell carcinoma cells | Zinc induces cell cycle arrest and apoptosis by upregulation of WIG-1 in esophageal squamous cancer cell line EC109.
Guo W, Zou YB, Jiang YG, Wang RW, Zhao YP, Ma Z. | 09/17/2011 |
| WIG-1 might be a novel modifier in esophageal carcinogenesis, and the WIG-1 MAb should be useful in further study of the mechanism in WIG-1-related physiological reactions. | Preparation of a novel monoclonal antibody specific for WIG-1 and detection of its expression pattern in human esophageal carcinoma.
Zou YB, Guo W, Jiang YG, Wang RW, Zhao YP, Ma Z. | 02/26/2011 |
| The cellular distribution of the nuclear matrix protein matrin 3 is altered by novel phosphorylation induced by the alphaherpesvirus US3 kinase family. | The alphaherpesvirus US3/ORF66 protein kinases direct phosphorylation of the nuclear matrix protein matrin 3.
Erazo A, Yee MB, Banfield BW, Kinchington PR., Free PMC Article | 01/22/2011 |
| the p53 target Wig-1 is a previously undescribed AU-rich element-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response | The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element.
Vilborg A, Glahder JA, Wilhelm MT, Bersani C, Corcoran M, Mahmoudi S, Rosenstierne M, Grandér D, Farnebo M, Norrild B, Wiman KG., Free PMC Article | 01/21/2010 |
| Data demonstrated a direct interaction between Dicer and Wig-1 and both may play a common role in dsRNA-related gene regulation. | [Dicer interacts with Wig-1 protein].
Huang J, Wang HB, Yao L, Zheng XM, Radmark O. | 01/21/2010 |
| Wig-1-binding proteins, hnRNP A2/B1 and RNA Helicase A, both of which are involved in RNA processing, were identified. | The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA.
Prahl M, Vilborg A, Palmberg C, Jörnvall H, Asker C, Wiman KG. | 01/21/2010 |
| Results demonstrate that human Wig-1 can bind different types of double-stranded RNAs (dsRNAs), including dsRNAs resembling small interfering RNAs and microRNAs, and indicate that dsRNA binding has a role in Wig-1-mediated regulation of cell growth. | The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs.
Méndez Vidal C, Prahl M, Wiman KG. | 01/21/2010 |