| Neuroglobin overexpression in cerebellar neurons of Harlequin mice improves mitochondrial homeostasis and reduces ataxic behavior. | Neuroglobin overexpression in cerebellar neurons of Harlequin mice improves mitochondrial homeostasis and reduces ataxic behavior.
Cwerman-Thibault H, Malko-Baverel V, Le Guilloux G, Ratcliffe E, Mouri D, Torres-Cuevas I, Millán I, Saubaméa B, Mignon V, Boespflug-Tanguy O, Gressens P, Corral-Debrinski M., | 07/29/2024 |
| Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice. | Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice.
Gøtzsche CR, Woldbye DPD, Hundahl CA, Hay-Schmidt A., Free PMC Article | 08/27/2022 |
| Probing the Role of Murine Neuroglobin CDloop-D-Helix Unit in CO Ligand Binding and Structural Dynamics. | Probing the Role of Murine Neuroglobin CDloop-D-Helix Unit in CO Ligand Binding and Structural Dynamics.
Exertier C, Sebastiani F, Freda I, Gugole E, Cerutti G, Parisi G, Montemiglio LC, Becucci M, Viappiani C, Bruno S, Savino C, Zamparelli C, Anselmi M, Abbruzzetti S, Smulevich G, Vallone B., Free PMC Article | 08/27/2022 |
| Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy. | Lack of orientation selectivity of the heme insertion in murine neuroglobin revealed by resonance Raman spectroscopy.
Milazzo L, Exertier C, Becucci M, Freda I, Montemiglio LC, Savino C, Vallone B, Smulevich G. | 05/22/2021 |
| A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning. | A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
Rose JJ, Bocian KA, Xu Q, Wang L, DeMartino AW, Chen X, Corey CG, Guimarães DA, Azarov I, Huang XN, Tong Q, Guo L, Nouraie M, McTiernan CF, O'Donnell CP, Tejero J, Shiva S, Gladwin MT., Free PMC Article | 12/26/2020 |
| These results indicate Ngb to be involved in and affected by the SOD1(G93A) pathology, which could in part be attributed to its role in halting destabilizing events of mitochondrial swelling and phenotypes. | Non-Methylation-Linked Mechanism of REST-Induced Neuroglobin Expression Impacts Mitochondrial Phenotypes in a Mouse Model of Amyotrophic Lateral Sclerosis.
Van Acker ZP, Declerck K, Luyckx E, Vanden Berghe W, Dewilde S. | 03/7/2020 |
| Ngb promotes axon regeneration via oxygen-Ngb-p38-GAP43 signaling during ischemia/reperfusion. | Neuroglobin boosts axon regeneration during ischemic reperfusion via p38 binding and activation depending on oxygen signal.
Xiong XX, Pan F, Chen RQ, Hu DX, Qiu XY, Li CY, Xie XQ, Tian B, Chen XQ., Free PMC Article | 08/3/2019 |
| This is the first report demonstrating a similar pattern of Ngb expression during disease progression in the brains of R6/2 mice. | Localization of neuroglobin in the brain of R6/2 mouse model of Huntington's disease.
Cardinale A, Fusco FR, Paldino E, Giampà C, Marino M, Nuzzo MT, D'Angelo V, Laurenti D, Straccia G, Fasano D, Sarnataro D, Squillaro T, Paladino S, Melone MAB. | 08/18/2018 |
| NGB proved to act cytoprotectively during MI in the acute setting while this effect was less pronounced in the atherosclerosis model. | Cytoprotective effects of transgenic neuroglobin overexpression in an acute and chronic mouse model of ischemic heart disease.
Luyckx E, Everaert BR, Van der Veken B, Van Leuven W, Timmermans JP, Vrints CJ, De Meyer GRY, Martinet W, Dewilde S. | 07/21/2018 |
| Study showed that in Neuroglobin (Ngb) knockout mice, distortion-product otoacoustic emissions thresholds were moderately augmented in the range of 5-18kHz. Results suggest that the lack of NgB, results in only marginal deficits in hearing ability. | Hearing Without Neuroglobin.
Nowotny M, Kiefer L, Andre D, Fabrizius A, Hankeln T, Reuss S. | 06/30/2018 |
| Ngb-H64Q-CCC binds CO about 500 times more strongly than hemoglobin, which could be useful in detecting and eliminating carbon monoxide poisoning | Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.
Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT., Free PMC Article | 12/30/2017 |
| Ngb can bind to mitochondrial complex III subunit Cyc1, leading to suppression of oxygen-glucose deprivation -mediated complex III activity. | Roles of Neuroglobin Binding to Mitochondrial Complex III Subunit Cytochrome c1 in Oxygen-Glucose Deprivation-Induced Neurotoxicity in Primary Neurons.
Yu Z, Zhang Y, Liu N, Yuan J, Lin L, Zhuge Q, Xiao J, Wang X. | 12/23/2017 |
| Reduction of Ngb expression in mouse retina after optic nerve injury.Ngb role in neuroregeneration in mice after optic nerve injury. | A novel function of neuroglobin for neuroregeneration in mice after optic nerve injury.
Sugitani K, Koriyama Y, Sera M, Arai K, Ogai K, Wakasugi K. | 10/28/2017 |
| Findings provide evidence for the loss of globin-linked neuroprotection to be linked to Alzheimer's disease angiopathogenesis, while raising the possibility of REST/ NRSF being an upstream regulator. | Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels.
Van Acker ZP, Luyckx E, Van Leuven W, Geuens E, De Deyn PP, Van Dam D, Dewilde S., Free PMC Article | 09/23/2017 |
| Ngb expression is limited to the subpopulation of type I spiral ganglion cells, those which innervate inner hair cells, while the subpopulation of type II spiral ganglion cells which innervate the outer hair cells do not express Ngb. The cochlear nuclei and superior olivary complex (SOC) also express considerable amounts of Ngb. | Neuroglobin Expression in the Mammalian Auditory System.
Reuss S, Banica O, Elgurt M, Mitz S, Disque-Kaiser U, Riemann R, Hill M, Jaquish DV, Koehrn FJ, Burmester T, Hankeln T, Woolf NK., Free PMC Article | 03/4/2017 |
| Ngb functions as a metabolic regulator and enhances cellular anabolism through the inhibition of AMPK signaling. | Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism.
Cai B, Li W, Mao X, Winters A, Ryou MG, Liu R, Greenberg DA, Wang N, Jin K, Yang SH., Free PMC Article | 12/17/2016 |
| Data show that the neuroglobin (Ngb) protein was downregulated in the retinal ganglion cells after optic nerve injury. | A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina.
Sugitani K, Koriyama Y, Ogai K, Wakasugi K, Kato S. | 04/23/2016 |
| Overexpression of neuroglobin reduced sensorimotor deficits following TBI. An endogenous increase in neuroglobin expression occurs during the subacute period. Increasing neuroglobin expression during the acute period after TBI may improve recovery. | Neuroglobin overexpression improves sensorimotor outcomes in a mouse model of traumatic brain injury.
Taylor JM, Kelley B, Gregory EJ, Berman NE., Free PMC Article | 03/21/2015 |
| reflect lesser perturbations produced by acute inhalation of combustion smoke in the Ngb overexpressing mouse, suggesting that Ngb mitigates mitochondrial dysfunction and neurotoxicity and raises the threshold of smoke inhalation-induced brain injury | Neuroglobin mitigates mitochondrial impairments induced by acute inhalation of combustion smoke in the mouse brain.
Gorgun FM, Zhuo M, Singh S, Englander EW., Free PMC Article | 01/3/2015 |
| A critical role for neuroglobin is demonstrated via its differential interaction with phosphatase and tensin homolog (PTEN) and Akt during neurite induction. | Neuroglobin promotes neurite outgrowth via differential binding to PTEN and Akt.
Li L, Liu QR, Xiong XX, Liu JM, Lai XJ, Cheng C, Pan F, Chen Y, Yu SB, Yu AC, Chen XQ. | 11/8/2014 |
| Neuroglobin overexpression resulted in a significant reduction in infarct volume 24 hours after brain ischemia. | Neuroglobin over expressing mice: expression pattern and effect on brain ischemic infarct size.
Raida Z, Hundahl CA, Nyengaard JR, Hay-Schmidt A., Free PMC Article | 05/3/2014 |
| Ngb overexpression can inhibit oxygen-glucose deprivation-induced mitochondria permeability transition opening in primary cultured mouse cortical | Neuroglobin overexpression inhibits oxygen-glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons.
Yu Z, Liu N, Li Y, Xu J, Wang X., Free PMC Article | 01/11/2014 |
| CREB may also mediate transcriptional regulation of neuroglobin gene. | Transcriptional regulation of mouse neuroglobin gene by cyclic AMP responsive element binding protein (CREB) in N2a cells.
Liu N, Yu Z, Li Y, Yuan J, Zhang J, Xiang S, Wang X., Free PMC Article | 06/22/2013 |
| Ngb deficiency neither affected the level of Melanopsin and Tyrosine Hydroxylase proteins nor the intactness of PACAP-positive retinohypothalamic projections in the suprachiasmatic nucleus. | Restricted expression of Neuroglobin in the mouse retina and co-localization with Melanopsin and Tyrosine Hydroxylase.
Hundahl CA, Fahrenkrug J, Luuk H, Hay-Schmidt A, Hannibal J. | 02/23/2013 |
| This study demonistrated that Ngb over-expression reduced traumatic lesion volume. | Neuroglobin-overexpression reduces traumatic brain lesion size in mice.
Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X., Free PMC Article | 12/22/2012 |