| Identification of amino acids in transmembrane domains of mutated cytokine receptor-like factor 2 and interleukin-7 receptor alpha required for constitutive signal transduction. | Identification of amino acids in transmembrane domains of mutated cytokine receptor-like factor 2 and interleukin-7 receptor α required for constitutive signal transduction.
Yamamoto R, Segawa R, Kato H, Niino Y, Sato T, Hiratsuka M, Hirasawa N. | 10/7/2024 |
| HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort. | HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort.
Page EC, Heatley SL, Eadie LN, McClure BJ, de Bock CE, Omari S, Yeung DT, Hughes TP, Thomas PQ, White DL. | 07/28/2024 |
| TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts. | TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts.
Wang D, Wang F, Huang Y, Wang J, Luo H, Zhang P, Peng J, Tang G, Wang Y, Yu L, Ni D. | 07/27/2023 |
| The prognostic significance of CRLF2 expression at diagnosis in adult Ph-negative B-cell precursor acute lymphoblastic leukemia. | The prognostic significance of CRLF2 expression at diagnosis in adult Ph-negative B-cell precursor acute lymphoblastic leukemia.
Wang J, Sun K, Chen WM, Wang X, Li LD, Hao Y, Xu N, Jiang H, Xu LP, Wang Y, Zhang XH, Huang XJ, Jiang Q, Qin YZ. | 03/24/2023 |
| Prognostic significance of CRLF2 overexpression and JAK2 mutation in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia. | Prognostic significance of CRLF2 overexpression and JAK2 mutation in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia.
Hassan NM, Abdellateif MS, Radwan EM, Hameed SA, Desouky EDE, Kamel MM, Gameel AM. | 06/11/2022 |
| High occurrence of CRLF2 abnormalities in Mexican children with B-cell acute lymphoblastic leukemia. | High occurrence of CRLF2 abnormalities in Mexican children with B-cell acute lymphoblastic leukemia.
Juárez-Velázquez MDR, Moreno-Lorenzana DL, Martínez Anaya DA, Hernández Monterde EA, Aguilar-Hernández MM, Reyes-León A, Chávez-González MA, López Santiago N, Zapata Tarrés M, Juárez Villegas L, Rivera Sánchez N, Soto Lerma O, Vega-Vega L, Rivera Luna R, Pérez-Vera P. | 06/11/2022 |
| CRLF2 overexpression results in reduced B-cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome. | CRLF2 overexpression results in reduced B-cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome.
Junco JJ, Zorman B, Gant VU Jr, Muñoz J, Lacorazza HD, Sumazin P, Rabin KR., Free PMC Article | 05/28/2022 |
| CRLF2 overexpression defines an immature-like subgroup which is rescued through restoration of the PRC2 function in T-cell precursor acute lymphoblastic leukemia. | CRLF2 overexpression defines an immature-like subgroup which is rescued through restoration of the PRC2 function in T-cell precursor acute lymphoblastic leukemia.
Maciel ALT, Wolch K, Emerenciano M, Mansur MB. | 05/28/2022 |
| Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL. | Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL.
Sasaki K, Yamauchi T, Semba Y, Nogami J, Imanaga H, Terasaki T, Nakao F, Akahane K, Inukai T, Verhoeyen E, Akashi K, Maeda T., Free PMC Article | 03/12/2022 |
| Expression and Polymorphism of TSLP/TSLP Receptors as Potential Diagnostic Markers of Colorectal Cancer Progression. | Expression and Polymorphism of TSLP/TSLP Receptors as Potential Diagnostic Markers of Colorectal Cancer Progression.
Semlali A, Almutairi MH, Alamri A, Reddy Parine N, Arafah M, Almadi MA, Aljebreen AM, Alharbi O, Azzam NA, Almutairi R, Alanazi M, Rouabhia M., Free PMC Article | 02/12/2022 |
| Outcomes in patients with CRLF2 overexpressed acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation. | Outcomes in patients with CRLF2 overexpressed acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation.
Koller P, Saliba RM, Ledesma C, Rondon G, Popat U, Alousi A, Mehta R, Oran B, Olson A, Hosing C, Qazilbash M, Khouri I, Ciurea S, Shpall E, Jorgensen J, Wang S, Jain N, Jabbour E, Kantarjian H, Champlin R, Konopleva M, Kebriaei P. | 09/11/2021 |
| Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1). | Molecular basis for recognition of Gly/N-degrons by CRL2(ZYG11B) and CRL2(ZER1).
Yan X, Li Y, Wang G, Zhou Z, Song G, Feng Q, Zhao Y, Mi W, Ma Z, Dong C. | 09/4/2021 |
| Characterization of CRLF2 Expression in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia. | Characterization of CRLF2 Expression in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.
Rasekh EO, Atef AM, Khalil M, Ebeid E, Madney Y, Hamdy N. | 08/7/2021 |
| Hematological characteristics, cytogenetic features, and post-induction measurable residual disease in thymic stromal lymphopoietin receptor (TSLPR) overexpressed B-cell acute lymphoblastic leukemia in an Indian cohort. | Hematological characteristics, cytogenetic features, and post-induction measurable residual disease in thymic stromal lymphopoietin receptor (TSLPR) overexpressed B-cell acute lymphoblastic leukemia in an Indian cohort.
Virk H, Rana S, Sharma P, Bose PL, Yadav DD, Sachdeva MUS, Varma N, Trehan A, Lad D, Khadwal AR, Malhotra P, Sreedharanunni S. | 07/31/2021 |
| Increased prevalence of CRLF2 rearrangements in obesity-associated acute lymphoblastic leukemia. | Increased prevalence of CRLF2 rearrangements in obesity-associated acute lymphoblastic leukemia.
Mittelman SD, Kim J, Raca G, Li G, Oberley MJ, Orgel E., Free PMC Article | 07/31/2021 |
| Effects of different aberrations in the CRLF2 gene on the biological characteristics and drug sensitivities of Nalm6 cells. | Effects of different aberrations in the CRLF2 gene on the biological characteristics and drug sensitivities of Nalm6 cells.
Gu M, Jia Y, Xu M, Feng J, Tian Z, Ma X, Wang M, Wang J, Xu Y, Rao Q, Hao L, Mi Y, Yang W. | 06/19/2021 |
| Combined analysis of IKZF1 deletions and CRLF2 expression on prognostic impact in pediatric B-cell precursor acute lymphoblastic leukemia. | Combined analysis of IKZF1 deletions and CRLF2 expression on prognostic impact in pediatric B-cell precursor acute lymphoblastic leukemia.
Cui L, Gao C, Wang CJ, Zhao XX, Li WJ, Li ZG, Zheng HY, Wang TY, Zhang RD. | 05/1/2021 |
| [Clinical Features and Prognosis of Acute Lymphoblastic Leukemia Children with P2RY8-CRLF2 Gene Rearrangement]. | [Clinical Features and Prognosis of Acute Lymphoblastic Leukemia Children with P2RY8-CRLF2 Gene Rearrangement].
Zheng YZ, LE SH, Zheng H, Hua XL, Chen ZS, Zheng L, Chen C, Li M, Cai CX, Yang JH, Chen YQ, Gao QL, Chen YY, Li J, Hu JD. | 04/13/2021 |
| GATA3 rs3824662A allele in B-cell acute lymphoblastic leukemia in adults, adolescents and young adults: association with CRLF2 rearrangement and poor prognosis. | GATA3 rs3824662A allele in B-cell acute lymphoblastic leukemia in adults, adolescents and young adults: association with CRLF2 rearrangement and poor prognosis.
Koller PB, Zhang H, Kantarjian H, Jabbour E, Pierce S, Gocho Y, Roberts KG, Yang W, Mullighan CG, Yang J, Konopleva M, Jain N. | 03/20/2021 |
| Expression of TSLP and IL-33 receptors on sputum macrophages of asthma patients and healthy subjects. | Expression of TSLP and IL-33 receptors on sputum macrophages of asthma patients and healthy subjects.
Paplińska-Goryca M, Nejman-Gryz P, Proboszcz M, Kwiecień I, Hermanowicz-Salamon J, Grabczak EM, Krenke R. | 08/22/2020 |
| Two TSLP single nucleotide polymorphisms (SNPs) (rs10043985 and rs3806933) and one TSLPR SNP (rs36139698) showed significant correlations with smoking behavior, but not IL7R rs12516866 and rs1053496. rs10043985 showed a clear association with long-term smoking regardless of daily cigarette consumption. rs2289276 was associated with short-term smoking but not with daily cigarette consumption in Saudi Arabian population. | TSLP and TSLP receptors variants are associated with smoking.
Semlali A, Almutairi M, Azzi A, Reddy Parine N, AlAmri A, Alsulami S, Meshal Alumri T, Saud Alanazi M, Rouabhia M., Free PMC Article | 06/27/2020 |
| high CRLF2 expression is associated with recurrence in T cell acute lymphoblastic leukemia. | Clinical characterization and prognosis of T cell acute lymphoblastic leukemia with high CRLF2 gene expression in children.
Wang M, Wen J, Guo Y, Shen Y, An X, Hu Y, Xiao J., Free PMC Article | 03/28/2020 |
| These data suggest that suboptimal GC responses may in part underlie the poor clinical outcomes for patients with CRLF2 overexpression and provide rationale for combination therapy involving GCs and signal transduction inhibitors as a means of enhancing GC efficacy. | CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition.
Meyer LK, Delgado-Martin C, Maude SL, Shannon KM, Teachey DT, Hermiston ML., Free PMC Article | 03/7/2020 |
| Our study illustrates that the TSLP/TSLPR axis might be involved in the pathogenesis of CAD through upregulation of mRNA or protein expression of the referenced genes and might have additive effects on the CAD risk when combined with IL-33 signaling. | Genetic Regulation of the Thymic Stromal Lymphopoietin (TSLP)/TSLP Receptor (TSLPR) Gene Expression and Influence of Epistatic Interactions Between IL-33 and the TSLP/TSLPR Axis on Risk of Coronary Artery Disease.
Nie SF, Zha LF, Fan Q, Liao YH, Zhang HS, Chen QW, Wang F, Tang TT, Xia N, Xu CQ, Zhang JY, Lu YZ, Zeng ZP, Jiao J, Li YY, Xie T, Zhang WJ, Wang D, Wang CC, Fa JJ, Xiong HB, Ye J, Yang Q, Wang PY, Tian SH, Lv QL, Li QX, Qian J, Li B, Wu G, Wu YX, Yang Y, Yang XP, Hu Y, Wang QK, Cheng X, Tu X., Free PMC Article | 09/21/2019 |
| recurrence rate of pediatric acute lymphoblastic leukemia(ALL) with CRLF2 high expression is high, and CRLF2 high expression is an important prognostic factor for high risk of relapse in ALL children | [Clinical Significance of CRLF2 High Expression in Bone Marrow Mononuclear Cells from Children with Acute Lymphoblastic Leukemia].
Kuang WY, Li WL, Zheng MC, Yang HX, Zhang BS, Wu P, He S, Song N, Li RJ. | 08/31/2019 |