| Tenomodulin and Chondromodulin-1 Are Both Required to Maintain Biomechanical Function and Prevent Intervertebral Disc Degeneration. | Tenomodulin and Chondromodulin-1 Are Both Required to Maintain Biomechanical Function and Prevent Intervertebral Disc Degeneration.
Di Pauli von Treuheim T, Torre OM, Ferreri ED, Nasser P, Abbondandolo A, Delgado Caceres M, Lin D, Docheva D, Iatridis JC., Free PMC Article | 04/16/2022 |
| Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon. | Tenomodulin knockout mice exhibit worse late healing outcomes with augmented trauma-induced heterotopic ossification of Achilles tendon.
Delgado Caceres M, Angerpointner K, Galler M, Lin D, Michel PA, Brochhausen C, Lu X, Varadarajan AR, Warfsmann J, Stange R, Alt V, Pfeifer CG, Docheva D., Free PMC Article | 02/5/2022 |
| Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration. | Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration.
Lin D, Alberton P, Delgado Caceres M, Prein C, Clausen-Schaumann H, Dong J, Aszodi A, Shukunami C, Iatridis JC, Docheva D., Free PMC Article | 05/15/2021 |
| Tnmd-deficient mouse tendon stem/progenitor cells exhibit significantly reduced adhesion to collagen type I. | Tenomodulin regulates matrix remodeling of mouse tendon stem/progenitor cells in an ex vivo collagen I gel model.
Yin H, Caceres MD, Yan Z, Schieker M, Nerlich M, Docheva D. | 03/28/2020 |
| Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes | Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes.
Shukunami C, Takimoto A, Nishizaki Y, Yoshimoto Y, Tanaka S, Miura S, Watanabe H, Sakuma T, Yamamoto T, Kondoh G, Hiraki Y., Free PMC Article | 09/14/2019 |
| Tnmd is required for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing. | Tenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing.
Lin D, Alberton P, Caceres MD, Volkmer E, Schieker M, Docheva D., Free PMC Article | 06/9/2018 |
| The results of enhanced tenogenic differentiation and neotendon formation indicated that Tnmd may serve not only as a tenogenic marker but also as a positive regulator of MSCs tenogenic differentiation, which might be applied to MSCs-mediated tendon regeneration. | Enhanced tenogenic differentiation and tendon-like tissue formation by tenomodulin overexpression in murine mesenchymal stem cells.
Jiang Y, Shi Y, He J, Zhang Z, Zhou G, Zhang W, Cao Y, Liu W. | 05/26/2018 |
| our study demonstrates that Tnmd is required for proper tendon tissue adaptation to endurance running and aids in better understanding of the structural-functional relationships of tendon tissues. | Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load.
Dex S, Alberton P, Willkomm L, Söllradl T, Bago S, Milz S, Shakibaei M, Ignatius A, Bloch W, Clausen-Schaumann H, Shukunami C, Schieker M, Docheva D., Free PMC Article | 03/31/2018 |
| In vitro comparison of tenogenic differentiation potentials among bone marrow derived stem cells (BMSCs), adipose derived stem cells (ASCs), dermal fibroblasts (DFs) and tenocytes (TCs) of the same Tnmd transgenic mice. BMSCs exhibited the best tenogenic potential than other three cell types. | Conditional tenomodulin overexpression favors tenogenic lineage differentiation of transgenic mouse derived cells.
Shi Y, Xiong Y, Jiang Y, Zhang Z, Zhou G, Zhang W, Cao Y, He J, Liu W. | 02/4/2017 |
| Upon high-fat diet feeding, transgenic mice overexpressing Tnmd develop increased epididymal white adipose tissue (eWAT) mass, and preadipocytes derived from Tnmd transgenic mice display greater proliferation, consistent with elevated adipogenesis. | Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.
Senol-Cosar O, Flach RJ, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, Hardy OT, Noh HL, Kim JK, Wabitsch M, Scherer PE, Czech MP., Free PMC Article | 07/2/2016 |
| Loss of Tnmd affects significantly the self-renewal and senescence properties, but not the multipotential of tendon stem cells. | Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells.
Alberton P, Dex S, Popov C, Shukunami C, Schieker M, Docheva D., Free PMC Article | 12/5/2015 |
| In our study of MM development, the laminar structure regulating TeM also prevents vascular invasion during the formation of compartment of the MM. | Tenomodulin regulated the compartments of embryonic and early postnatal mouse masseter muscle.
Sato I, Miwa Y, Hara S, Fukuyama Y, Sunohara M. | 08/8/2015 |
| Tenomodulin is expressed abundantly in the elastin-rich subendothelial outer layer of the normal chordae tendineae cordis. | Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis.
Kimura N, Shukunami C, Hakuno D, Yoshioka M, Miura S, Docheva D, Kimura T, Okada Y, Matsumura G, Shin'oka T, Yozu R, Kobayashi J, Ishibashi-Ueda H, Hiraki Y, Fukuda K. | 01/21/2010 |
| The expression domains of ChM-I and TeM during vertebrate development incorporate the typical avascular regions of the mesenchymal tissues. | Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development.
Shukunami C, Takimoto A, Miura S, Nishizaki Y, Hiraki Y. | 01/21/2010 |
| Results suggest that tenomodulin (Tnmd) is a regulator of tenocyte proliferation and is involved in collagen fibril maturation but do not confirm an in vivo involvement of Tnmd in angiogenesis. | Tenomodulin is necessary for tenocyte proliferation and tendon maturation.
Docheva D, Hunziker EB, Fässler R, Brandau O., Free PMC Article | 01/21/2010 |