| Confirming the recessive inheritance of PERP-related erythrokeratoderma. | Confirming the recessive inheritance of PERP-related erythrokeratoderma.
Patel N, Alkeraye S, Alobeid E, Alshidi T, Helaby R, Abdulwahab F, Shamseldin HE, Alkuraya FS. | 06/5/2021 |
| Perp deletion promoted Th17 responses and exacerbated the development and severity of experimental autoimmune encephalomyelitis. | Loss of Perp in T Cells Promotes Resistance to Apoptosis of T Helper 17 Cells and Exacerbates the Development of Experimental Autoimmune Encephalomyelitis in Mice.
Zhou Y, Leng X, He Y, Li Y, Liu Y, Liu Y, Zou Q, Shi G, Wang Y., Free PMC Article | 06/8/2019 |
| Perp might play important roles in the formation and integration of stellate reticulum, dental lamina structure and enamel formation | Developmental regulations of Perp in mice molar morphogenesis.
Neupane S, Sohn WJ, Rijal G, Lee YJ, Lee S, Yamamoto H, An CH, Cho SW, Lee Y, Shin HI, Kwon TY, Kim JY. | 06/20/2015 |
| an important role for Perp in normal mammary tissue function and in mammary cancer suppression | Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer.
Dusek RL, Bascom JL, Vogel H, Baron S, Borowsky AD, Bissell MJ, Attardi LD., Free PMC Article | 04/27/2013 |
| Data show that PERP is necessary for the integrity of the ameloblast-SI interface and that a lack of Perp causes downregulation of genes that are required for proper enamel formation. | PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.
Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD., Free PMC Article | 07/2/2011 |
| Studies suggest that Perp-deficiency promotes cancer by enhancing cell survival, desmosome loss, and inflammation, and they highlight a fundamental role for Perp and desmosomes in tumor suppression. | Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.
Beaudry VG, Jiang D, Dusek RL, Park EJ, Knezevich S, Ridd K, Vogel H, Bastian BC, Attardi LD., Free PMC Article | 03/12/2011 |
| pemphigus vulgaris autoantibodies disrupt Perp expression at the membrane and trigger its internalization along with DSG3 into the endosomal pathway, where it is ultimately targeted to the lysosome for degradation | Loss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies.
Nguyen B, Dusek RL, Beaudry VG, Marinkovich MP, Attardi LD., Free PMC Article | 01/21/2010 |
| PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia. | PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia.
Singaravelu K, Devalaraja-Narashimha K, Lastovica B, Padanilam BJ. | 01/21/2010 |
| A paper describing the identification of Perp (p53 Apoptosis Effector Related to PMP22). Perp was found as a novel target gene of the p53 tumor suppressor, which is selectively induced during apoptosis compared to cell cycle arrest. | PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family.
Attardi LD, Reczek EE, Cosmas C, Demicco EG, McCurrach ME, Lowe SW, Jacks T., Free PMC Article | 11/28/2008 |
| Perp's requirement for both viability and epithelial integrity reflects a role in the stratified epithelial compartment. | The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia.
Marques MR, Ihrie RA, Horner JS, Attardi LD., Free PMC Article | 01/21/2010 |
| Perp is requered throughout adult life for proper epithelial homeostasis and function. | Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes.
Ihrie RA, Bronson RT, Attardi LD. | 01/21/2010 |
| In contrast to p53 shRNAs, PUMA shRNAs were unable to cooperate with oncogenic ras in transformation | Suppression of tumorigenesis by the p53 target PUMA.
Hemann MT, Zilfou JT, Zhao Z, Burgess DJ, Hannon GJ, Lowe SW., Free PMC Article | 01/21/2010 |
| Perp is required for efficient skin carcinogenesis and suggest a role for intact cell-cell adhesion in supporting tumor development in these settings. | Mice lacking the p53/p63 target gene Perp are resistant to papilloma development.
Marques MR, Horner JS, Ihrie RA, Bronson RT, Attardi LD. | 01/21/2010 |
| Perp is a key effector in the p63 developmental program. | Perp is a p63-regulated gene essential for epithelial integrity.
Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD. | 01/21/2010 |