| The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma. | The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma.
Moragas N, Fernandez-Nogueira P, Recalde-Percaz L, Inman JL, López-Plana A, Bergholtz H, Noguera-Castells A, Del Burgo PJ, Chen X, Sorlie T, Gascón P, Bragado P, Bissell M, Carbó N, Fuster G., Free PMC Article | 09/24/2024 |
| Reverse effect of Semaphorin-3F on rituximab resistance in diffuse large B-cell lymphoma via the Hippo pathway. | Reverse effect of Semaphorin-3F on rituximab resistance in diffuse large B-cell lymphoma via the Hippo pathway.
Li Q, Ma N, Li X, Yang C, Zhang W, Xiong J, Zhu L, Li J, Wen Q, Gao L, Yang C, Rao L, Gao L, Zhang X, Rao J., Free PMC Article | 06/26/2023 |
| Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling. | Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling.
Duncan BW, Mohan V, Wade SD, Truong Y, Kampov-Polevoi A, Temple BR, Maness PF., Free PMC Article | 01/1/2022 |
| Semaphorin 3fa Controls Ocular Vascularization From the Embryo Through to the Adult. | Semaphorin 3fa Controls Ocular Vascularization From the Embryo Through to the Adult.
Halabi R, Watterston C, Hehr CL, Mori-Kreiner R, Childs SJ, McFarlane S., Free PMC Article | 07/24/2021 |
| Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. | Semaphorin 3F signaling actively retains neutrophils at sites of inflammation.
Plant T, Eamsamarng S, Sanchez-Garcia MA, Reyes L, Renshaw SA, Coelho P, Mirchandani AS, Morgan JM, Ellett FE, Morrison T, Humphries D, Watts ER, Murphy F, Raffo-Iraolagoitia XL, Zhang A, Cash JL, Loynes C, Elks PM, Van Eeden F, Carlin LM, Furley AJ, Whyte MK, Walmsley SR., Free PMC Article | 02/6/2021 |
| Semaphorin 3F Serves as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and is Associated With Lymph Node Metastasis in Disease Progression. | Semaphorin 3F Serves as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and is Associated With Lymph Node Metastasis in Disease Progression.
Xie Z, Li T, Huang B, Liu S, Zhang L, Zhang Q., Free PMC Article | 01/9/2021 |
| Endothelial Semaphorin 3F Maintains Endothelial Barrier Function and Inhibits Monocyte Migration. | Endothelial Semaphorin 3F Maintains Endothelial Barrier Function and Inhibits Monocyte Migration.
Zhang H, Vreeken D, Junaid A, Wang G, Sol WMPJ, de Bruin RG, van Zonneveld AJ, van Gils JM., Free PMC Article | 11/21/2020 |
| The level of SEMA3F was significantly higher in normal prostate tissues compared with that in prostate cancer cells. | Clinical relevance of semaphorin-3F in patients with prostate cancer.
Wu G. | 08/1/2020 |
| SEMA3F was significantly upregulated in hepatocellular carcinoma tissue and was associated with poor survival. SEMA3F promoted hepatocellular carcinoma metastasis by activating focal adhesion pathway. | SEMA3F Promotes Liver Hepatocellular Carcinoma Metastasis by Activating Focal Adhesion Pathway.
Ye K, Ouyang X, Wang Z, Yao L, Zhang G. | 03/21/2020 |
| SEMA 3F is recommended as an important therapeutic agent for the prevention of pathological angiogenesis. SEMA 3F may offer an effective and efficient anti-angiogenic intervention that can be administered at a lower dose alternative to typical VEGF blocking agents. | Inhibitory effects of Semaphorin 3F as an alternative candidate to anti-VEGF monoclonal antibody on angiogenesis.
Tan G. | 03/7/2020 |
| Familial chronic megacolon appears to be associated with SEMA3F, which is associated with genes impacting enteric nerve or pacemaker function. | Familial chronic megacolon presenting in childhood or adulthood: Seeking the presumed gene association.
Camilleri M, Wieben E, Eckert D, Carlson P, Hurley O'Dwyer R, Gibbons D, Acosta A, Klee EW., Free PMC Article | 02/8/2020 |
| SEMA3F plays a role as a tumor suppressor in Oral squamous cell carcinoma cell proliferation, migration and invasion. | The crucial role of SEMA3F in suppressing the progression of oral squamous cell carcinoma.
Liu Y, Li R, Yin K, Ren G, Zhang Y., Free PMC Article | 07/28/2018 |
| in situ hybridization analysis revealed that Sema 3C and Sema 3F are expressed at the RNA level in the endometriosis affected peritoneum | Reduced Sympathetic Innervation in Endometriosis is Associated to Semaphorin 3C and 3F Expression.
Scheerer C, Frangini S, Chiantera V, Mechsner S. | 05/12/2018 |
| Semaphorin 3F placenta tissue expression was significantly reduced in preeclampsia. In addition, semaphorin 3F level at delivery was significantly lower in serum, amniotic fluid and venous umbilical blood of preeclamptic patients compared with normal pregnant women. | Semaphorin 3F expression is reduced in pregnancy complicated by preeclampsia. An observational clinical study.
Stallone G, Matteo M, Netti GS, Infante B, Di Lorenzo A, Prattichizzo C, Carlucci S, Trezza F, Gesualdo L, Greco P, Grandaliano G., Free PMC Article | 09/9/2017 |
| There is a positive association between the expression of AKAP12 and Semaphorin 3F in prostate cancer, suggesting that the activation of Semaphorin 3F by AKAP12 may be involved in prostate cancer progression and metastasis. | SSeCKS/AKAP12 induces repulsion between human prostate cancer and microvessel endothelial cells through the activation of Semaphorin 3F.
Xie W, Su W, Zhang L, Shang Q, Su B. | 08/12/2017 |
| Study demonstrates an anti-tumoral role of SEMA3F in ileal NETs. We thus suggest that SEMA3F and/or its cellular signaling pathway could represent a target for ileal NET therapy. | The axon guidance molecule semaphorin 3F is a negative regulator of tumor progression and proliferation in ileal neuroendocrine tumors.
Bollard J, Massoma P, Vercherat C, Blanc M, Lepinasse F, Gadot N, Couderc C, Poncet G, Walter T, Joly MO, Hervieu V, Scoazec JY, Roche C., Free PMC Article | 03/4/2017 |
| SEMA3F was downregulated in colorectal cancer tissues as compared to matched adjacent non-tumor tissues | Semaphorin-3F functions as a tumor suppressor in colorectal cancer due to regulation by DNA methylation.
Gao X, Tang C, Shi W, Feng S, Qin W, Jiang T, Sun Y., Free PMC Article | 10/22/2016 |
| A new SEMA3F transcript is expressed in all breast cell lines and breast cancer biopsies, and is translated into a new semaphorin 3F isoform. | Alternative Splicing in Adhesion- and Motility-Related Genes in Breast Cancer.
Aversa R, Sorrentino A, Esposito R, Ambrosio MR, Amato A, Zambelli A, Ciccodicola A, D'Apice L, Costa V., Free PMC Article | 10/22/2016 |
| SEMA3F-NRP2 interactions inhibit intracellular PI-3K activity, mTORC2-dependent signaling, RhoA activity and cytoskeletal stress fiber formation. | Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo.
Nakayama H, Bruneau S, Kochupurakkal N, Coma S, Briscoe DM, Klagsbrun M., Free PMC Article | 08/6/2016 |
| Data indicate that semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) are expressed in the thymus. | Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors.
Mendes-da-Cruz DA, Brignier AC, Asnafi V, Baleydier F, Messias CV, Lepelletier Y, Bedjaoui N, Renand A, Smaniotto S, Canioni D, Milpied P, Balabanian K, Bousso P, Leprêtre S, Bertrand Y, Dombret H, Ifrah N, Dardenne M, Macintyre E, Savino W, Hermine O., Free PMC Article | 12/5/2015 |
| SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis. | SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.
Zhou ZH, Rao J, Yang J, Wu F, Tan J, Xu SL, Ding Y, Zhan N, Hu XG, Cui YH, Zhang X, Dong W, Liu XD, Bian XW. | 10/10/2015 |
| SEMA3F may represent an antilymphangiogenic metastasis suppressor gene widely lost during cancer progression, hence serving as a prognostic biomarker and an attractive target for therapeutic intervention to halt metastasis. | Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma.
Doçi CL, Mikelis CM, Lionakis MS, Molinolo AA, Gutkind JS., Free PMC Article | 10/10/2015 |
| Infantile hemangioma-derived stem cells and endothelial cells are inhibited by SEMA3E and SEMA3F. | Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins.
Nakayama H, Huang L, Kelly RP, Oudenaarden CR, Dagher A, Hofmann NA, Moses MA, Bischoff J, Klagsbrun M., Free PMC Article | 10/3/2015 |
| Our findings demonstrate the ability of SEMA3F to inhibit the stemness of human CRC cells by suppressing Rac1 activation, which suggests a novel therapeutic approach for colorectal cancer | Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1.
Rao J, Zhou ZH, Yang J, Shi Y, Xu SL, Wang B, Ping YF, Chen L, Cui YH, Zhang X, Wu F, Bian XW. | 03/28/2015 |
| Data suggest that SEMA3F C-terminal domain exhibits high-affinity binding of neuropilin-1 (NRP1; thus inhibiting binding of vascular endothelial growth factor A to NRP1); this interaction may be involved in anti-angiogenic activity of SEMA3F. | Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F.
Guo HF, Li X, Parker MW, Waltenberger J, Becker PM, Vander Kooi CW., Free PMC Article | 02/15/2014 |