| Genetic tuning of beta-carotene oxygenase-1 activity rescues cone photoreceptor function in STRA6-deficient mice. | Genetic tuning of β-carotene oxygenase-1 activity rescues cone photoreceptor function in STRA6-deficient mice.
Moon J, Ramkumar S, von Lintig J., Free PMC Article | 02/24/2023 |
| beta-Carotene Oxygenase 1 Activity Modulates Circulating Cholesterol Concentrations in Mice and Humans. | β-Carotene Oxygenase 1 Activity Modulates Circulating Cholesterol Concentrations in Mice and Humans.
Amengual J, Coronel J, Marques C, Aradillas-García C, Morales JMV, Andrade FCD, Erdman JW, Teran-Garcia M., Free PMC Article | 11/21/2020 |
| provided novel experimental evidence that BCO1 and BCO2 could play a significant role in maintaining normal hepatic lipid and cholesterol homeostasis, potentially through the regulation of the FXR/miR-34a/SIRT1 pathway | Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway.
Lim JY, Liu C, Hu KQ, Smith DE, Wang XD. | 07/6/2019 |
| This is the first demonstration that Bco1 disruption lowers murine circulating testosterone levels and thereby reduces prostatic androgen receptor signaling and prostatic cellular proliferation, further supporting the role of this protein in processes more diverse than carotenoid cleavage. | Mice lacking β-carotene-15,15'-dioxygenase exhibit reduced serum testosterone, prostatic androgen receptor signaling, and prostatic cellular proliferation.
Smith JW, Ford NA, Thomas-Ahner JM, Moran NE, Bolton EC, Wallig MA, Clinton SK, Erdman JW Jr., Free PMC Article | 07/1/2017 |
| tissue- and sex-specific effects of beta-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism | Tissue- and sex-specific effects of β-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice.
Kim YK, Zuccaro MV, Costabile BK, Rodas R, Quadro L., Free PMC Article | 06/27/2015 |
| BCO1 modulates heart metabolism and function, possibly by altering levels of cofactors required for the actions of nuclear hormone receptors | Cardiac dysfunction in β-carotene-15,15'-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism.
Lee SA, Jiang H, Trent CM, Yuen JJ, Narayanasamy S, Curley RW Jr, Harrison EH, Goldberg IJ, Maurer MS, Blaner WS., Free PMC Article | 01/24/2015 |
| Dietary wolfberry elevated the xanthophyll concentrations and enhanced expression of BCO2 and heat shock protein 60, activated AMPKalpha2, potentiated mitophagy and mitochondrial biogenesis and enhanced lipid oxidation and secretion in the liver of mice. | Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: the role of AMP-activated protein kinase α2 subunit.
Lin D, He H, Ji H, Willis J, Willard L, Jiang Y, Medeiros DM, Wark L, Han J, Liu Y, Lu B. | 12/20/2014 |
| Pleiotropic actions of Carotene-15,15'-monooxygenase and carotene-9',10'-monooxygenase supporting a strong role of these proteins in regulating tissue carotenoid accumulation as well as tomato carotenoid-independent regulation of lipid metabolism. | Genetic ablation of carotene oxygenases and consumption of lycopene or tomato powder diets modulate carotenoid and lipid metabolism in mice.
Ford NA, Elsen AC, Erdman JW Jr., Free PMC Article | 04/26/2014 |
| in addition to cleaving beta-carotene to generate retinoids, CMOI serves an additional function(s) in retinoid and lipid metabolism and point to its role in the formation of specific lipids, possibly for use in nervous system tissue. | Loss of β-carotene 15,15'-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols.
Dixon JL, Kim YK, Brinker A, Quadro L., Free PMC Article | 02/22/2014 |
| a stepwise cleavage by BCO2 and BCO1 with APO10ol as an intermediate could provide a mechanism to tailor asymmetric carotenoids such as beta-cryptoxanthin for vitamin A production. | Two carotenoid oxygenases contribute to mammalian provitamin A metabolism.
Amengual J, Widjaja-Adhi MAK, Rodriguez-Santiago S, Hessel S, Golczak M, Palczewski K, von Lintig J., Free PMC Article | 02/8/2014 |
| beta-Carotene and its cleavage enzyme beta-carotene-15,15'-oxygenase (CMOI) affect retinoid metabolism in developing tissues. | β-Carotene and its cleavage enzyme β-carotene-15,15'-oxygenase (CMOI) affect retinoid metabolism in developing tissues.
Kim YK, Wassef L, Chung S, Jiang H, Wyss A, Blaner WS, Quadro L., Free PMC Article | 07/2/2011 |
| Gene expression in lungs is changed in the opposite direction by beta-carotene in male and female Bcmo1 -/- mice. | Beta-carotene affects gene expression in lungs of male and female Bcmo1 (-/-) mice in opposite directions.
van Helden YG, Godschalk RW, Swarts HJ, Hollman PC, van Schooten FJ, Keijer J., Free PMC Article | 03/19/2011 |
| In Bcmo1-deficient mice, Fzd6 AND Cthrc1 genes are upregulated. | Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice.
van Helden YG, Godschalk RW, Heil SG, Bunschoten A, Hessel S, Amengual J, Bonet ML, von Lintig J, van Schooten FJ, Keijer J. | 09/20/2010 |
| Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene. | Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene.
van Helden YG, Heil SG, van Schooten FJ, Kramer E, Hessel S, Amengual J, Ribot J, Teerds K, Wyss A, Lietz G, Bonet ML, von Lintig J, Godschalk RW, Keijer J., Free PMC Article | 06/28/2010 |
| The role of conserved catalytic site aromatic residues in the catalytic mechanism of BCMO1 is consistent with the formation of a substrate carbocation intermediate and cation-pi stabilization. | Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase.
Poliakov E, Gentleman S, Chander P, Cunningham FX Jr, Grigorenko BL, Nemuhin AV, Redmond TM., Free PMC Article | 03/15/2010 |
| Cadmium induces retinoic acid signaling by regulating retinoic acid metabolic gene (BCMO-1) expression | Cadmium induces retinoic acid signaling by regulating retinoic acid metabolic gene expression.
Cui Y, Freedman JH., Free PMC Article | 01/21/2010 |
| CMO1 is the key enzyme for vitamin A production in mice and alters lipid metabolism. | CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice.
Hessel S, Eichinger A, Isken A, Amengual J, Hunzelmann S, Hoeller U, Elste V, Hunziker W, Goralczyk R, Oberhauser V, von Lintig J, Wyss A. | 01/21/2010 |
| CMO I KO mice fed low levels of vitamin A have altered lycopene biodistribution and isomer patterns and do not cleave beta-carotene to vitamin A at appreciable levels. | Lycopene biodistribution is altered in 15,15'-carotenoid monooxygenase knockout mice.
Lindshield BL, King JL, Wyss A, Goralczyk R, Lu CH, Ford NA, Erdman JW Jr., Free PMC Article | 01/21/2010 |
| Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine. | Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression.
Seino Y, Miki T, Kiyonari H, Abe T, Fujimoto W, Kimura K, Takeuchi A, Takahashi Y, Oiso Y, Iwanaga T, Seino S. | 01/21/2010 |
| elevation of beta-carotene 15,15'-dioxygenase activity in hairless mice after UV exposure may be a response to reduction of the skin retinoid concentration | Measurement of retinoids and beta-carotene 15,15'-dioxygenase activity in HR-1 hairless mouse skin with UV exposure.
Takeda A, Morinobu T, Takitani K, Kimura M, Tamai H. | 01/21/2010 |
| the conserved histidines and Glu405 are absolutely required for the catalytic mechanism of BCMO1 | Key role of conserved histidines in recombinant mouse beta-carotene 15,15'-monooxygenase-1 activity.
Poliakov E, Gentleman S, Cunningham FX Jr, Miller-Ihli NJ, Redmond TM. | 01/21/2010 |
| Transcriptional activation of the beta-carotene 15, 15'-monooxygenase gene by peroxisome proliferator-activated receptor (beta-carotene 15, 15'-monooxygenase). | Identification of beta-carotene 15, 15'-monooxygenase as a peroxisome proliferator-activated receptor target gene.
Boulanger A, McLemore P, Copeland NG, Gilbert DJ, Jenkins NA, Yu SS, Gentleman S, Redmond TM. | 01/21/2010 |