| Rhomboid domain containing 1 promotes the growth of non-small cell lung cancer through the activation of EGFR and regulation of the BIK-mediated apoptosis. | Rhomboid domain containing 1 promotes the growth of non-small cell lung cancer through the activation of EGFR and regulation of the BIK-mediated apoptosis.
Xu ZY, Li X, Yao RH, Yang LM, Peng H, Ren WJ, Lu H, Wang P. | 07/9/2022 |
| RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival. | RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival.
Taniue K, Tanu T, Shimoura Y, Mitsutomi S, Han H, Kakisaka R, Ono Y, Tamamura N, Takahashi K, Wada Y, Mizukami Y, Akimitsu N., Free PMC Article | 01/29/2022 |
| Correlation of the protein expression of GRP78 and BIK/NBK with prognostic markers in patients with breast cancer and neoadjuvant chemotherapy. | Correlation of the protein expression of GRP78 and BIK/NBK with prognostic markers in patients with breast cancer and neoadjuvant chemotherapy.
López-Muñoz E, Corres-Molina M, García-Hernández N. | 12/12/2020 |
| study reveals that different cellular stresses regulate BIK ubiquitination by ASB11 in opposing directions, which determines whether or not cells survive, and that blocking BIK degradation has the potential to be used as an anti-cancer strategy. | BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.
Chen FY, Huang MY, Lin YM, Ho CH, Lin SY, Chen HY, Hung MC, Chen RH., Free PMC Article | 05/16/2020 |
| BIK knockdown mimicked, while overexpression reversed the protective effects of miR-1306-5p against OGD/R induced injury | Upregulation of miR-1306-5p decreases cerebral ischemia/reperfusion injury in vitro by targeting BIK.
Chen X, Li C, Li J, Sheng L, Liu X. | 02/15/2020 |
| The current studies demonstrate that the proinflammatory IL-13 induces Bcl-2 in airway epithelial cells. Because IL-13 also induces the proapoptotic Bik, targeted blocking of Bcl-2 function switches IL-13 into a cell death inducer. | Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner.
Chand HS, Mebratu YA, Kuehl PJ, Tesfaigzi Y., Free PMC Article | 06/1/2019 |
| the results revealed the autophagy modulator TMEM74 interrelates with apoptosis inducer BIK and inhibits its function. | Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis.
Sun Y, Li Q, Zhang J, Chen Z, He Q, Liu X, Zhao N, Yin A, Huang H, He M, Cao L, Wang L. | 03/10/2018 |
| Data suggest that the ERalpha-H19-BIK signaling axis plays an important role in promoting breast cancer cell chemoresistance. | LncRNA H19 confers chemoresistance in ERα-positive breast cancer through epigenetic silencing of the pro-apoptotic gene BIK.
Si X, Zang R, Zhang E, Liu Y, Shi X, Zhang E, Shao L, Li A, Yang N, Han X, Pan B, Zhang Z, Sun L, Sun Y., Free PMC Article | 02/24/2018 |
| Suggest complex mechanism of tumor promotion in Bik high breast tumors. | The pro-apoptotic paradox: the BH3-only protein Bcl-2 interacting killer (Bik) is prognostic for unfavorable outcomes in breast cancer.
Pandya V, Glubrecht D, Vos L, Hanson J, Damaraju S, Mackey J, Hugh J, Goping IS., Free PMC Article | 12/23/2017 |
| BIK significantly contributes to DNA damage-induced mitochondrial apoptosis in HCT-116 wt cells upstream of the second peak of ROS production, BAX and BAK activation, cytochrome c release and caspase activation. | Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells.
Kutuk O, Aytan N, Karakas B, Kurt AG, Acikbas U, Temel SG, Basaga H., Free PMC Article | 10/21/2017 |
| These studies suggest a link between Bik-mediated caspase activation and cleavage of viral proteins. | Bik Mediates Caspase-Dependent Cleavage of Viral Proteins to Promote Influenza A Virus Infection.
Mebratu YA, Tipper J, Chand HS, Walton S, Harrod KS, Tesfaigzi Y., Free PMC Article | 07/1/2017 |
| our data demonstrated that suppression of BIK in ER-positive MCF-7 cells prevents the cytotoxic effect of TAM and favors a more aggressive phenotype, due to the molecular change of different pathways | Involvement of multiple cellular pathways in regulating resistance to tamoxifen in BIK-suppressed MCF-7 cells.
Viedma-Rodríguez R, Ruiz Esparza-Garrido R, Baiza-Gutman LA, Velázquez-Flores MÁ, García-Carrancá A, Salamanca-Gómez F, Arenas-Aranda D. | 02/27/2016 |
| HCV RNA replication and release were significantly suppressed in BIK-depleted cells and over-expression of the RNA-dependent RNA polymerase, NS5B, was able to induce BIK expression | NS5B induces up-regulation of the BH3-only protein, BIK, essential for the hepatitis C virus RNA replication and viral release.
Aweya JJ, Sze CW, Bayega A, Mohd-Ismail NK, Deng L, Hotta H, Tan YJ., Free PMC Article | 04/25/2015 |
| BikDDA, a novel mutant of Bik, showed a prolonged half-life and enhanced pro-apoptotic ability in triple-negative breast cancer cells compared with BikDD. | BikDDA, a mutant of Bik with longer half-life expression protein, can be a novel therapeutic gene for triple-negative breast cancer.
Jiao S, Wu M, Ye F, Tang H, Xie X, Xie X., Free PMC Article | 11/22/2014 |
| Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis. | Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
Chen S, Zhou L, Zhang Y, Leng Y, Pei XY, Lin H, Jones R, Orlowski RZ, Dai Y, Grant S., Free PMC Article | 10/18/2014 |
| Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1. | Repression of the proapoptotic cellular BIK/NBK gene by Epstein-Barr virus antagonizes transforming growth factor β1-induced B-cell apoptosis.
Campion EM, Hakimjavadi R, Loughran ST, Phelan S, Smith SM, D'Souza BN, Tierney RJ, Bell AI, Cahill PA, Walls D., Free PMC Article | 06/7/2014 |
| Data suggest BIK expression in tumor cells is not subject to direct regulation by MAP kinase signaling; BIK expression appears to be cell-cycle-dependent and increases in G1 cell-cycle arrest which results from inhibition of MAP kinase signaling. | The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G₁ cell-cycle arrest and not a direct effect on BIK protein stability.
Sale MJ, Cook SJ. | 06/7/2014 |
| BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients | BIK/NBK gene as potential marker of prognostic and therapeutic target in breast cancer patients.
López-Muñoz E, Hernández-Zarco A, García-Hernández N, Alvarado-Cabrero I, Zarco-Espinosa G, Salamanca-Gómez F, Arenas-Aranda D. | 07/27/2013 |
| Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. | Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
Lopez J, Hesling C, Prudent J, Popgeorgiev N, Gadet R, Mikaelian I, Rimokh R, Gillet G, Gonzalo P., Free PMC Article | 06/22/2013 |
| A previously undescribed indirect epigenetic regulation of BIK in FA-C lymphoblasts is mediated by DeltaNp73, an isoform of p73 lacking its transactivation domain that activates BIK through a proximal element in its promoter. | BIK (NBK) is a mediator of the sensitivity of Fanconi anaemia group C lymphoblastoid cell lines to interstrand DNA cross-linking agents.
Prieto-Remón I, Sánchez-Carrera D, López-Duarte M, Richard C, Pipaón C. | 01/26/2013 |
| Data indicate that methylation-induced transcriptional silencing of the BIK (bcl2-interacting killer) pro-apoptotic gene may occur in multiple myeloma (MM), which might serve as a predictor of the development of relapsed/refractory MM. | Bcl2-interacting killer CpG methylation in multiple myeloma: a potential predictor of relapsed/refractory disease with therapeutic implications.
Hatzimichael E, Dasoula A, Kounnis V, Benetatos L, Lo Nigro C, Lattanzio L, Papoudou-Bai A, Dranitsaris G, Briasoulis E, Crook T. | 01/5/2013 |
| Data show that association of study-wide significance (P < 8.2 x 10(-5)) was identified for single-nucleotide polymorphisms (SNP) in TP53, LIG1, and BIK. | Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study.
Leng S, Stidley CA, Liu Y, Edlund CK, Willink RP, Han Y, Landi MT, Thun M, Picchi MA, Bruse SE, Crowell RE, Van Den Berg D, Caporaso NE, Amos CI, Siegfried JM, Tesfaigzi Y, Gilliland FD, Belinsky SA., Free PMC Article | 03/31/2012 |
| GRP78 can decrease BCL-2 sequestration by BIK at the endoplasmic reticulum | Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK).
Zhou H, Zhang Y, Fu Y, Chan L, Lee AS., Free PMC Article | 09/17/2011 |
| Bik has a role in both, apoptosis induction and sensitivity to oxidative stress in myeloma cells. | BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma.
Bodet L, Ménoret E, Descamps G, Pellat-Deceunynck C, Bataille R, Le Gouill S, Moreau P, Amiot M, Gomez-Bougie P., Free PMC Article | 01/8/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |